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Bone Marrow Transplantation (20)
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Showing 1–50 of 58 results

Advanced filters: Author: Matthias Eder Clear advanced filters

Neuronal hyperactivity in neurons derived from individuals with gray matter heterotopia

Periventricular heterotopia (PH) is associated with neurodevelopmental delay. Here authors report patient-derived organoids with FAT4 and DCHS1 mutations mimic PH features, showing hyperactivity, synaptic changes and cell morphological alterations.

Francesco Di Matteo
Rebecca Bonrath
Silvia Cappello
ResearchOpen Access18 Feb 2025
Nature Communications

Volume: 16, P: 1-14
FKBP51 in glutamatergic forebrain neurons promotes early life stress inoculation in female mice

Early life stress can induce lasting changes in brain function and behavior. Here, authors show that glutamatergic FKBP51 specifically in females mediates adaptive stress effects on anxiety and cognition via TCF4.

Lotte van Doeselaar
Alexandra Abromeit
Mathias V. Schmidt
ResearchOpen Access14 Mar 2025
Nature Communications

Volume: 16, P: 1-16
Prognostic significance of cytogenetic risk score in patients with secondary acute myeloid leukemia undergoing allogeneic stem cell transplantation from HLA-matched unrelated donors: a study from the ALWP /EBMT

Arnon Nagler
Allain-Thibeault Ferhat
Fabio Ciceri
ResearchOpen Access29 May 2025
Bone Marrow Transplantation

P: 1-10
Ultramicroscopy: three-dimensional visualization of neuronal networks in the whole mouse brain

Hans-Ulrich Dodt
Ulrich Leischner
Klaus Becker
Research25 Mar 2007
Nature Methods

Volume: 4, P: 331-336
A decision point between transdifferentiation and programmed cell death priming controls KRAS-dependent pancreatic cancer development

The involvement of cell death pathways in the early stage of pancreatic ductal adenocarcinoma (PDAC) development, especially KRAS-dependent acinar-to-ductal metaplasia (ADM), remains to be investigated. Here, the authors find that TAK1 mediates cell survival during ADM transdifferentiation through suppression of apoptosis and necroptosis, which could be targeted for prevention and treatment of PDAC.

Anne T. Schneider
Christiane Koppe
Tom Luedde
ResearchOpen Access19 Feb 2025
Nature Communications

Volume: 16, P: 1-18
Cytogenetic and molecular risk-driven conditioning intensity in acute myeloid leukemia patients undergoing stem cell transplantation with post-transplant cyclophosphamide: a study from the acute leukemia working party of the EBMT

Jaime Sanz
Myriam Labopin
Fabio Ciceri
Research12 Feb 2025
Bone Marrow Transplantation

Volume: 60, P: 529-534
Donor regulatory T cells rapidly adapt to recipient tissues to control murine acute graft-versus-host disease

Graft-versus-Host disease is a major complication after allogeneic bone marrow transplantation and is ameliorated by adoptively transferred donor regulatory T cells. Here, the authors apply transcriptomic and TCR profiling to assess regulatory T cell organ-specific adaptation in murine bone marrow transplantation models.

David J. Dittmar
Franziska Pielmeier
Michael Rehli
ResearchOpen Access15 Apr 2024
Nature Communications

Volume: 15, P: 1-16
Allogeneic stem cell transplantation in de novo core-binding factor acute myeloid leukemia in active disease: a study from the Acute Leukemia Working Party of the European Society for Blood and Marrow Transplantation

Sara Tarantino
Myriam Labopin
Fabio Ciceri
Research23 Apr 2025
Bone Marrow Transplantation

P: 1-9
Erratum: LEF-1 is crucial for neutrophil granulocytopoiesis and its expression is severely reduced in congenital neutropenia

Julia Skokowa
Gunnar Cario
Karl Welte
Amendments and Corrections01 Nov 2006
Nature Medicine

Volume: 12, P: 1329
Microbial short-chain fatty acids modulate CD8⁺ T cell responses and improve adoptive immunotherapy for cancer

The activity of immune cells can be regulated by the microbiome. Here, the authors show that the fatty acids pentanoate and butyrate—normally released by the microbiome—increase the anti-tumour activity of cytotoxic T lymphocytes and chimeric antigen receptor T cells through metabolic and epigenetic reprogramming.

Maik Luu
Zeno Riester
Alexander Visekruna
ResearchOpen Access01 Jul 2021
Nature Communications

Volume: 12, P: 1-12
Sarcoma classification by DNA methylation profiling

Sarcomas are morphologically heterogeneous tumours rendering their classification challenging. Here the authors developed a classifier using DNA methylation data from several soft tissue and bone sarcoma subtypes, which has the potential to improve classification for research and clinical purposes.

Christian Koelsche
Daniel Schrimpf
Andreas von Deimling
ResearchOpen Access21 Jan 2021
Nature Communications

Volume: 12, P: 1-10
PTCy versus ATG as graft-versus-host disease prophylaxis in mismatched unrelated stem cell transplantation

Olaf Penack
Mouad Abouqateb
Zinaida Peric
ResearchOpen Access15 Mar 2024
Blood Cancer Journal

Volume: 14, P: 1-8
Heterologous protection against malaria by a simple chemoattenuated PfSPZ vaccine regimen in a randomized trial

In this placebo-controlled trial, 10/13 malaria naïve subjects immunized with a simplified regimen of chemoattenuated P. falciparum sporozoites, PfSPZ-CVac, show sterile protection from heterologous malaria challenge. Immunization was well tolerated and induced high levels of anti-PfCSP antibodies.

Zita Sulyok
Rolf Fendel
Peter G. Kremsner
ResearchOpen Access04 May 2021
Nature Communications

Volume: 12, P: 1-10
Long term results of a prospective multicenter observational study on the use of anti-human T-lymphocyte immunoglobulin (ATLG) in unrelated donor transplantation (ATOS study)

Jürgen Finke
Claudia Schmoor
Olga Grishina
ResearchOpen Access16 Mar 2024
Bone Marrow Transplantation

Volume: 59, P: 936-941
GVHD prophylaxis in matched related stem cell transplantation: Why post-transplant cyclophosphamide can be recommended a study by the EBMT transplant complications working party

Olaf Penack
Mouad Abouqateb
Zinaida Peric
ResearchOpen Access17 Apr 2025
Leukemia

Volume: 39, P: 1503-1511
Suppression of antitumor T cell immunity by the oncometabolite (R)-2-hydroxyglutarate

An oncometabolite produced by tumor cells acts as a paracrine immunosuppressant dampening antitumor T cell responses in glioma.

Lukas Bunse
Stefan Pusch
Michael Platten
Research09 Jul 2018
Nature Medicine

Volume: 24, P: 1192-1203
Comparison of fludarabine/melphalan (FM140) with fludarabine/melphalan/BCNU (FBM110) in patients with relapsed/refractory AML undergoing allogeneic hematopoietic cell transplantation – a registry study on behalf of the EBMT Acute Leukemia Working Party

Jesús Duque-Afonso
Jürgen Finke
Mohamad Mohty
ResearchOpen Access19 Dec 2024
Bone Marrow Transplantation

Volume: 60, P: 373-379
Current use of PSMA–PET in prostate cancer management

Prostate-specific membrane antigen (PSMA) has gained increasing interest as target molecule for imaging. Several small compounds for labelling PSMA have been developed and are currently being investigated as imaging probes for PET. PSMA-based imaging has been reported to improve detection of metastatic disease compared with CT or multiparametric MRI and⁶⁸Ga-PSMA–PET imaging has been shown to increase detection of metastatic sites, therefore, it holds great promise to improve prostate cancer management.

Tobias Maurer
Matthias Eiber
Jürgen E. Gschwend
Reviews23 Feb 2016
Nature Reviews Urology

Volume: 13, P: 226-235
Allogeneic stem-cell transplantation with sequential conditioning in adult patients with refractory or relapsed acute lymphoblastic leukemia: a report from the EBMT Acute Leukemia Working Party

Abdul Hamid Bazarbachi
Rama Al Hamed
Mohamad Mohty
Research27 Sept 2019
Bone Marrow Transplantation

Volume: 55, P: 595-602
MLL-fusion-driven leukemia requires SETD2 to safeguard genomic integrity

In leukemia, diverse fusion proteins involving the MLL gene can drive oncogenic activity. Here, the authors describe a dependency of MLL-leukemia cells on the methyltransferase SETD2 to maintain genomic integrity during leukemia initiation and maintenance.

Anna Skucha
Jessica Ebner
Florian Grebien
ResearchOpen Access18 May 2018
Nature Communications

Volume: 9, P: 1-16
Nectin-3 links CRHR1 signaling to stress-induced memory deficits and spine loss

Early-life stress, acting through corticotrophin-releasing hormone (CRH) and its receptor CRHR1, can have long-lasting effects on animals' behavior. Nectin-3 is a cell adhesion molecule whose heterodimeric interaction with presynaptic nectin-1 organizes the postsynaptic afadin–actin–N-cadherin complex to shape synaptic structure and function. Here, the authors show that structural synaptic adaptation and cognitive dysfunction in adulthood following early-life stress are dependent on CRH signaling acting through Nectin-3.

Xiao-Dong Wang
Yun-Ai Su
Mathias V Schmidt
Research05 May 2013
Nature Neuroscience

Volume: 16, P: 706-713
Ucn3 and CRF-R2 in the medial amygdala regulate complex social dynamics

Social encounters are associated with varying degrees of stress. The authors show that modulation of stress system components in the medial amygdala alters preference for familiar vs. novel conspecifics. Inhibition of the relevant circuit in a group of familiar mice kept under semi-natural conditions increased pro-social behavior.

Yair Shemesh
Oren Forkosh
Alon Chen
Research18 Jul 2016
Nature Neuroscience

Volume: 19, P: 1489-1496
T cells armed with C-X-C chemokine receptor type 6 enhance adoptive cell therapy for pancreatic tumours

Forced expression of C-X-C chemokine receptor type 6 in antigen-specific T cells enhanced the recognition and lysis of pancreatic cancer cells and the efficacy of adoptive cell therapy for pancreatic cancer.

Stefanie Lesch
Viktoria Blumenberg
Sebastian Kobold
Research03 Jun 2021
Nature Biomedical Engineering

Volume: 5, P: 1246-1260
Mechanisms governing the pioneering and redistribution capabilities of the non-classical pioneer PU.1

PU.1 is a master TF of hematopoietic lineage differentiation. Here the authors analyse properties of PU.1 DNA-binding in vitro and genome-wide in vivo across different cell types with native or ectopic PU.1 expression, and uncover the mechanisms governing the pioneering and redistribution capabilities of the non-classical pioneer PU.1.

Julia Minderjahn
Andreas Schmidt
Michael Rehli
ResearchOpen Access21 Jan 2020
Nature Communications

Volume: 11, P: 1-16
Satisfactory outcomes following a second autologous hematopoietic cell transplantation for multiple myeloma in poor stem cell mobilizers: a retrospective study on behalf of the Chronic Malignancies Working Party of the EBMT

Matjaz Sever
Joanna Drozd-Sokolowska
Donal P. McLornan
Research12 Nov 2024
Bone Marrow Transplantation

Volume: 60, P: 211-219
Alcohol facilitates detection of concealed identity information

Kristina Suchotzki
Matthias Gamer
ResearchOpen Access18 May 2018
Scientific Reports

Volume: 8, P: 1-6
LEF-1 is crucial for neutrophil granulocytopoiesis and its expression is severely reduced in congenital neutropenia

Julia Skokowa
Gunnar Cario
Karl Welte
Research24 Sept 2006
Nature Medicine

Volume: 12, P: 1191-1197
The role of anti-thymocyte globulin in allogeneic stem cell transplantation (HSCT) from HLA-matched unrelated donors (MUD) for secondary AML in remission: a study from the ALWP /EBMT

Arnon Nagler
Myriam Labopin
Mohamad Mohty
Research02 Sept 2023
Bone Marrow Transplantation

Volume: 58, P: 1339-1347
Cacna1c deficiency in forebrain glutamatergic neurons alters behavior and hippocampal plasticity in female mice

Srivaishnavi Loganathan
Danusa Menegaz
Jan M. Deussing
ResearchOpen Access06 Oct 2024
Translational Psychiatry

Volume: 14, P: 1-11
Oligoclonal CD4⁺CXCR5⁺ T cells with a cytotoxic phenotype appear in tonsils and blood

Most subsets of CD4⁺ T-follicular helper cells occur in blood and tonsils, but ___location enforces specific gene expression. One subtype reveals a cytotoxic phenotype, is circulating or extrafollicular, oligoclonal and shares TCRs with other clusters.

Chunguang Liang
Silvia Spoerl
Friederike Berberich-Siebelt
ResearchOpen Access18 Jul 2024
Communications Biology

Volume: 7, P: 1-16
A bipolar disorder-associated missense variant alters adenylyl cyclase 2 activity and promotes mania-like behavior

Paromita Sen
Oskar Ortiz
Jan M. Deussing
ResearchOpen Access13 Jul 2024
Molecular Psychiatry

Volume: 30, P: 97-110
Optimized induction of mitochondrial apoptosis for chemotherapy-free treatment of BCR-ABL+acute lymphoblastic leukemia

Michaela Scherr
Hanna Kirchhoff
Matthias Eder
ResearchOpen Access13 Dec 2018
Leukemia

Volume: 33, P: 1313-1323
Unmanipulated haploidentical versus HLA-matched sibling allogeneic hematopoietic stem cell transplantation in relapsed/refractory acute myeloid leukemia: a retrospective study on behalf of the ALWP of the EBMT

Giorgia Battipaglia
Ariane Boumendil
Arnon Nagler
Research04 Feb 2019
Bone Marrow Transplantation

Volume: 54, P: 1499-1510
Allogeneic hematopoietic stem-cell transplantation for patients with Richter transformation: a retrospective study on behalf of the Chronic Malignancies Working Party of the EBMT

Romain Guièze
Diderik-Jan Eikema
Donal P. McLornan
Research19 Mar 2024
Bone Marrow Transplantation

Volume: 59, P: 950-956
Treosulfan compared to busulfan in allogeneic haematopoietic stem cell transplantation for myelofibrosis: a registry-based study from the Chronic Malignancies Working Party of the EBMT

Marie Robin
Simona Iacobelli
Donal P. McLornan
Research15 Mar 2024
Bone Marrow Transplantation

Volume: 59, P: 928-935
Management and outcome of patients with chronic myeloid leukemia in blast phase in the tyrosine kinase inhibitor era – analysis of the European LeukemiaNet Blast Phase Registry

Annamaria Brioli
Elza Lomaia
Michael Lauseker
ResearchOpen Access28 Mar 2024
Leukemia

Volume: 38, P: 1072-1080
Allogeneic haematopoietic cell transplantation for therapy-related myeloid neoplasms arising following treatment for lymphoma: a retrospective study on behalf of the Chronic Malignancies Working Party of the EBMT

Mitja Nabergoj
Diderik-Jan Eikema
Donal P. McLornan
Research09 Jan 2024
Bone Marrow Transplantation

Volume: 59, P: 395-402
A unique role of p53 haploinsufficiency or loss in the development of acute myeloid leukemia with FLT3-ITD mutation

Min Yang
Zengkai Pan
Zhixiong Li
ResearchOpen Access03 Nov 2021
Leukemia

Volume: 36, P: 675-686
The impact of pre-transplantation diabetes and obesity on acute graft-versus-host disease, relapse and death after allogeneic hematopoietic cell transplantation: a study from the EBMT Transplant Complications Working Party

Lars Klingen Gjærde
Tapani Ruutu
Zinaida Perić
ResearchOpen Access07 Dec 2023
Bone Marrow Transplantation

Volume: 59, P: 255-263
Comparison of fludarabine/melphalan (FluMel) with fludarabine/melphalan/BCNU or thiotepa (FBM/FTM) in patients with AML in first complete remission undergoing allogeneic hematopoietic stem cell transplantation – a registry study on behalf of the EBMT Acute Leukemia Working Party

Jesús Duque-Afonso
Jürgen Finke
Mohamad Mohty
ResearchOpen Access02 Dec 2023
Bone Marrow Transplantation

Volume: 59, P: 247-254
Adrenocortical carcinoma: a clinician's update

Adrenocortical carcinoma is a rare heterogeneous neoplasm with an incompletely understood pathogenesis and a poor prognosis. No general consensus on the diagnostic and therapeutic measures for adrenocortical carcinoma exists, but collaborative efforts have substantially advanced the field. This Review provides an updated approach to the patient with suspected adrenocortical carcinoma and discusses etiology, diagnosis and treatment options.

Martin Fassnacht
Rossella Libé
Bruno Allolio
Reviews08 Mar 2011
Nature Reviews Endocrinology

Volume: 7, P: 323-335
Efficient treatment of murine acute GvHD by in vitro expanded donor regulatory T cells

Christin Riegel
Tina J. Boeld
Matthias Edinger
ResearchOpen Access12 Nov 2019
Leukemia

Volume: 34, P: 895-908
Impact of chronic graft-versus-host-disease on intensive care outcome in allogeneic hematopoietic stem cell recipients

Catherina Lueck
Asterios Tzalavras
Tobias Liebregts
ResearchOpen Access10 Dec 2022
Bone Marrow Transplantation

Volume: 58, P: 303-310
Augmented FLAMSA-Bu versus FluBu2 reduced-intensity conditioning in patients with active relapsed/refractory acute myeloid leukemia: an EBMT analysis

Eduardo Rodríguez-Arbolí
Myriam Labopin
Mohamad Mohty
Research07 Apr 2022
Bone Marrow Transplantation

Volume: 57, P: 934-941
Conditionally immortalised leukaemia initiating cells co-expressing Hoxa9/Meis1 demonstrate microenvironmental adaptation properties ex vivo while maintaining myelomonocytic memory

Maike Stahlhut
Teng Cheong Ha
Olga S. Kustikova
ResearchOpen Access05 Mar 2021
Scientific Reports

Volume: 11, P: 1-18
The co-chaperone Fkbp5 shapes the acute stress response in the paraventricular nucleus of the hypothalamus of male mice

Alexander S. Häusl
Lea M. Brix
Mathias V. Schmidt
ResearchOpen Access01 Mar 2021
Molecular Psychiatry

Volume: 26, P: 3060-3076
QTL mapping of modelled metabolic fluxes reveals gene variants impacting yeast central carbon metabolism

Matthias Eder
Thibault Nidelet
Sylvie Dequin
ResearchOpen Access07 Feb 2020
Scientific Reports

Volume: 10, P: 1-14
Haploidentical CD3 or α/β T-cell depleted HSCT in advanced stage sickle cell disease

Juergen Foell
Johannes H Schulte
Selim Corbacioglu
Research14 May 2019
Bone Marrow Transplantation

Volume: 54, P: 1859-1867
Correction: Long term results of a prospective multicenter observational study on the use of anti-human T-lymphocyte immunoglobulin (ATLG) in unrelated donor transplantation (ATOS study)

Jürgen Finke
Claudia Schmoor
Olga Grishina
Amendments and CorrectionsOpen Access23 Apr 2024
Bone Marrow Transplantation

Volume: 59, P: 1204
Correction: Treosulfan compared to busulfan in allogeneic haematopoietic stem cell transplantation for myelofibrosis: a registry-based study from the Chronic Malignancies Working Party of the EBMT

Marie Robin
Simona Iacobelli
Donal P. McLornan
Amendments and Corrections13 May 2024
Bone Marrow Transplantation

Volume: 59, P: 1205

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