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Structure-based design of native-like HIV-1 envelope trimers to silence non-neutralizing epitopes and eliminate CD4 binding

Eliciting broadly neutralizing antibodies (bnAbs) is a primary HIV vaccine goal, but available immunogens expose epitopes for development of non-nAbs. Here, the authors use computational and structure-guided design to develop improved native-like envelope trimers and analyze Ab response in animal models.

Daniel W. Kulp
Jon M. Steichen
William R. Schief
ResearchOpen Access21 Nov 2017
Nature Communications

Volume: 8, P: 1-14
Differential processing of HIV envelope glycans on the virus and soluble recombinant trimer

HIV envelope (Env) is a potential vaccine antigen and its N-glycans are part of the epitope of broadly neutralizing antibodies. Here, the authors show that glycosylation of Env from infectious virus closely matches Env from recombinant membrane-bound trimers, while it differs significantly from recombinant soluble, cleaved Env trimers.

Liwei Cao
Matthias Pauthner
James C. Paulson
ResearchOpen Access12 Sept 2018
Nature Communications

Volume: 9, P: 1-14
Genome-wide association study identifies human genetic variants associated with fatal outcome from Lassa fever

GWAS in difficult-to-recruit populations identifies variants associated with Lassa fever outcome and susceptibility at loci proximal to LIF, GRM7 and LARGE1.

Dylan Kotliar
Siddharth Raju
Pardis C. Sabeti
ResearchOpen Access07 Feb 2024
Nature Microbiology

Volume: 9, P: 751-762
Integration of genomic sequencing into the response to the Ebola virus outbreak in Nord Kivu, Democratic Republic of the Congo

Phylogeographic analysis of 792 Ebola virus genomes from the 2018 oubreak in the Democratic Republic of the Congo integrated into an end-to-end surveillance program demonstrates the feasibility of using genomic sequencing data to inform the public health epidemic response in near-real time.

Eddy Kinganda-Lusamaki
Allison Black
Jean-Jacques Muyembe Tamfum
Research12 Apr 2021
Nature Medicine

Volume: 27, P: 710-716
Predicting the evolution of the Lassa virus endemic area and population at risk over the next decades

It is currently unknown how climate and land use changes could affect the endemic area of Lassa virus, a zoonotic pathogen responsible for Lassa fever. Here, the authors show that by 2070, new regions in Africa will likely become ecologically suitable for Lassa virus, drastically increasing the population living in conditions favourable for virus circulation.

Raphaëlle Klitting
Liana E. Kafetzopoulou
Simon Dellicour
ResearchOpen Access27 Sept 2022
Nature Communications

Volume: 13, P: 1-15
An HIV-1 antibody from an elite neutralizer implicates the fusion peptide as a site of vulnerability

The cryo-EM structure of an HIV-1 broadly neutralizing antibody from an elite neutralizer reveals the fusion peptide of the envelope glycoprotein (Env) as a site of vulnerability that may be explored by future therapies.

Marit J. van Gils
Tom L. G. M. van den Kerkhof
Rogier W. Sanders
Research14 Nov 2016
Nature Microbiology

Volume: 2, P: 1-10
Global site-specific N-glycosylation analysis of HIV envelope glycoprotein

The analysis of site-specific glycosylation of HIV Envelope glycoprotein (Env) is challenging as it contains 25–30 glycosylation sites with multiple glycan forms at each site. Here the authors present a generally applicable mass spectrometry-based method for site-specific analysis of protein glycosylation that they apply to the analysis of the HIV-1 Env.

Liwei Cao
Jolene K. Diedrich
James C. Paulson
ResearchOpen Access28 Mar 2017
Nature Communications

Volume: 8, P: 1-13
Priming antibody responses to the fusion peptide in rhesus macaques

Christopher A. Cottrell
Payal P. Pratap
Andrew B. Ward
ResearchOpen Access12 Jul 2024
npj Vaccines

Volume: 9, P: 1-14
Global site-specific analysis of glycoprotein N-glycan processing

This protocol describes a semiquantitative glycoproteomics method using sequential treatment with endoglycosidases to create unique mass signatures to determine glycan occupancy and proportion of high-mannose and complex glycans at each glycosite.

Liwei Cao
Jolene K Diedrich
James C Paulson
Protocols03 May 2018
Nature Protocols

Volume: 13, P: 1196-1212

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