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White matter hyperintensities (WMH) are a common brain-imaging feature of cerebral small vessel disease. Here, the authors carry out a GWAS and followup analyses for WMH-volume, implicating several variants with potential for risk stratification and drug targeting.

The development of techniques capable of orchestrating the assembly of living cells into multicellular ensembles with synergistic and function is challenge. Here, the authors construct algal or algal/bacterial cells-based core shell-like structure based on aqueous two-phase system for synergic photosynthetic H₂ production.

A new type of Hall effect—the layer Hall effect—is produced in a 2D antiferromagnet that does not exhibit any net magnetization.

Deep whole-genome sequencing of 300 individuals from 142 diverse populations provides insights into key population genetic parameters, shows that all modern human ancestry outside of Africa including in Australasians is consistent with descending from a single founding population, and suggests a higher rate of accumulation of mutations in non-Africans compared to Africans since divergence.

This study presents the assembly and analysis of the genome sequence of a female domestic Duroc pig and a comparison with the genomes of wild and domestic pigs from Europe and Asia; the results shed light on the evolutionary relationship between European and Asian wild boars.

Magnetic, wireless miniature devices are promising for healthcare, information technology, and many other field but lack advanced fabrication methods for micrometer length scales. Here authors present a molding-integrated direct laser writing fabrication protocol to fabricate 3D micron-scale devices with programmable magnetization and multi-material integration.

Genetic susceptibility loci for oropharyngeal cancer have been reported but these studies have not always examined human papillomavirus (HPV) status. Here, the authors perform genome-wide analysis taking into account HPV16 serology status and report two independent loci in the HLA region, suggesting the protective role of HLA variants against HPV infection.

The authors build a unified theoretical framework of black carbon mixing state and find a universal law, applicable in most climate/atmospheric chemistry models, which can greatly increase accuracy of black carbon climate effect estimation.

Adipose tissue expansion occurs via enlargement of adipocytes as well as the generation of new fat cells, the latter being associated with more favorable metabolic outcomes. Here, the authors show that activation of adipocyte Piezo1 results in release of FGF1 and stimulates the differentiation of adipocyte precursor cells.

Bright star \(\nu\) Indi shows elevated levels of alpha-process elements, suggesting great age, and is kinematically heated, probably from the merger of a dwarf galaxy with the Milky Way. Chaplin et al. make a case for \(\nu\) Indi being an accurate indicator of the timing for the Gaia–Enceladus merger.

Integration of GWAS and single-cell transcriptomic data from the entire nervous system systematically identifies cell types underlying brain complex traits and provides insights into the etiology of Parkinson’s disease.

Using short-read sequencing data, Evoracle reconstructs full-length genotypes and fitness during directed evolution experiments, and can identify low-frequency variants before they can be identified using consensus mutations.

A survey of species-level genes from 13,174 publicly available metagenomes shows that most species-level genes are specific to a single habitat, encode a small number of protein families and are under low positive (adaptive) pressure.

Crystal structures of the neuropeptide Y₁ receptor in complex with two distinct antagonists combined with NMR, molecular docking and mutagenesis studies inform a proposed model for receptor–agonist binding.

Under conditions such as hypoxia or starvation, an mTORC1-lipid signalling pathway initiates mitochondrial proteolysis by YME1L.

Pigs are important large animal models for biomedical research. Here, the authors construct a single-cell landscape of pig tissues, unravelling the phenotypic heterogeneity of blood endothelial cells in adipose tissues and the evolutionally conserved regulons of microglia in brains.

Sensing DNA bases by surface-enhanced Raman spectroscopy (SERS) in plasmonic nanopores has suffered from rapid flow through of molecules. Here, the authors attach DNA molecules to gold nanoparticles which, due to electro-plasmonic trapping, allow for controlled residence times and discrimination of single nucleotides.

The authors perform meta-analysis of GWAS studies for asthma from multiancestral cohorts. They identify five new loci and find that the asthma-associated loci are enriched near enhancer marks in immune cells.

The spread of wheat and barley involves evolutionary and human adaptation but has been difficult to date properly. Findings from a cave site suggest a much earlier transfer of cereal grains across Eurasia.

The off-target effects and on-target mutations of CRISPR editing in higher non-human primates are complex. Here the authors perform whole genome trio sequencing of rhesus monkeys and see no unexpected mutations.

Birthweight has been found to associate with later-life health outcomes. Here the authors perform a meta-analysis of epigenome-wide association studies of 8,825 neonates from 24 birth cohorts in the Pregnancy And Childhood Epigenetics Consortium, identifying differentially methylated CpGs in neonatal blood that associate with birthweight.

Analysis of whole-genome sequencing data across 2,658 tumors spanning 38 cancer types shows that chromothripsis is pervasive, with a frequency of more than 50% in several cancer types, contributing to oncogene amplification, gene inactivation and cancer genome evolution.

Analysis of mitochondrial genomes (mtDNA) by using whole-genome sequencing data from 2,658 cancer samples across 38 cancer types identifies hypermutated mtDNA cases, frequent somatic nuclear transfer of mtDNA and high variability of mtDNA copy number in many cancers.

Efficient, large-scale genomic analysis is facilitated on the cloud by a computational tool with error-diagnosing and self-healing capabilities.

Actuation of hydrogel actuators relies on slow swelling and de-swelling process which hampers its application in many fields. Here the authors report a light-powered in-air hydrogel actuator with remarkable performances including fast motion, speed and rapid response time.

The basic mechanisms behind the East Asian Summer Monsoon remain poorly understood. Using proxy-based reconstructions and simulations, here the authors show that changes in the orientation and position of the westerly jet stream resulted in regionally asynchronous Holocene precipitation maxima.

Structural variants (SVs) in human genomes contribute diversity and diseases. Here, the authors use a multi-platform strategy to generate haplotype-resolved SVs for three human parent–child trios.

Large-scale, unbiased proteomics studies of biological samples like plasma are constrained by the complexity of the proteome. Herein, the authors develop a highly parallel protein quantitation platform leveraging multi nanoparticle protein coronas for deep proteome sampling and biomarker discovery.

Poly(vinylidene fluoride) exhibits a negative longitudinal piezoelectric coefficient. In situ X-ray diffraction measurements suggest that this effect is dependent on electromechanical coupling between the intermixed crystalline lamellae and amorphous regions.

Two-dimensional materials have many desirable properties but controllable synthesis is difficult. Now, a flux-assisted growth approach has been designed to reproducibly prepare high-quality, atomically thin materials. Eighty atomically thin composite flakes have been prepared by this approach.

Understanding the coherent dynamics of electron and nucleus spins in hBN is crucial for their applications as qubits and quantum sensors. Here the authors report room-temperature coherent manipulation of the negatively charged boron vacancy spins in hBN and study their dynamics under weak and strong magnetic fields.

Comparative genomic analysis of 3,837 bacterial genomes, including new sequences from 484 root-associated isolates, identifies plant-associated gene clusters and plant-mimicking domains.

Wear-resistant metals have long been a pursuit of reducing wear-related energy and material loss. Here the authors present the ‘reactive wear protection’ strategy via friction-induced in situ formation of strong and deformable oxide nanocomposites on a surface.

Software tools for larger-scale intact glycopeptide quantification lag far behind, which hinders exploring the differential sitespecific glycosylation. Here, the authors report pGlycoQuant, a generic tool with a deep learning model for quantitative glycoproteomics at intact glycopeptide level.

This resource describes a collection of neurons from a variety of light microscopy-based datasets, which can serve as a gold standard for testing automated tracing algorithms, as shown by comparison of the performance of 35 algorithms.

Charge–density–wave correlations, quantum oscillations and Fermi-liquid charge transport are at the centre of a heated debate in cuprate superconductivity. Using resonant X-ray scattering, Tabis et al. investigate the charge order and its link to the electronic transport properties in HgBa₂CuO_4+δ.

1000 Genomes imputation can increase the power of genome-wide association studies to detect genetic variants associated with human traits and diseases. Here, the authors develop a method to integrate and analyse low-coverage sequence data and SNP array data, and show that it improves imputation performance.

The molecular pathways regulating the cardioprotective activity of deacetylase sirtuin-1 are unknown. Here, Yanget al. show that histone H3K9 methyltransferase SUV39H and HP1gamma cooperatively methylate H3K9 on the sirtuin-1 promoter and inhibit sirtuin-1 transcription, and show that inhibition of SUV39H in mice is cardioprotective.

Large-scale quantum simulations of gauge theories are relevant to high-energy and condensed matter physics. This Review covers recent developments in simulating lattice gauge theories using cold atoms.

Resistance-nodulation-cell division (RND)-type tripartite efflux pumps confer multidrug resistance to Gram-negative bacteria. Here, structural and functional analyses of AdeB from Acinetobacter baumannii and AcrB from Escherichia coli provide insight into their different drug-binding and conformational drug transport states.

As phase 1 of the Earth Microbiome Project, analysis of 16S ribosomal RNA sequences from more than 27,000 environmental samples delivers a global picture of the basic structure and drivers of microbial distribution.

The PARTHENOGENESIS (PAR) gene is identified in apomictic dandelion. A dominant allele has a MITE transposon insertion similar to that found in apomictic hawkweed. Expression of dandelion PAR in lettuce induces embryo-like structures without fertilization.