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Showing 1–4 of 4 results
Advanced filters: Author: Mayuko Tani Clear advanced filters

  • Genetic mechanisms influencing COVID-19 susceptibility are not well understood. Here, the authors analyzed whole blood RNA-seq data of 465 Japanese individuals with COVID-19, highlighting thousands of fine-mapped variants affecting expression and splicing of genes, as well as the presence of COVID-19 severity-interaction eQTLs.

    • Qingbo S. Wang
    • Ryuya Edahiro
    • Yukinori Okada
    ResearchOpen Access
    Nature Communications
    Volume: 13, P: 1-19

  • A genome-wide association study highlights a variant in DOCK2, which is common in East Asian populations but rare in Europeans, as a host genetic risk factor for severe COVID-19.

    • Ho Namkoong
    • Ryuya Edahiro
    • Yukinori Okada
    ResearchOpen Access
    Nature
    Volume: 609, P: 754-760

  • Analysis of the blood DNA virome in patients with COVID-19 and autoimmune disease associates endogenous HHV-6 (eHHV-6) and high anellovirus load with increased disease risk, most notably for systemic lupus erythematosus. eHHV-6 carriers show a distinct immune response.

    • Noah Sasa
    • Shohei Kojima
    • Yukinori Okada
    ResearchOpen Access
    Nature Genetics
    Volume: 57, P: 65-79

  • Peripheral blood mononuclear cells from 73 Japanese patients with coronavirus disease 2019 (COVID-19) and 75 healthy controls were analyzed using single-cell transcriptomics. Combining these data with genotyping data highlights the interplay between host genetics and the immune response in modulating disease severity.

    • Ryuya Edahiro
    • Yuya Shirai
    • Yukinori Okada
    ResearchOpen Access
    Nature Genetics
    Volume: 55, P: 753-767