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Mechanistic studies of mycobacterial glycolipid biosynthesis by the mannosyltransferase PimE

Here the authors investigate of the structural basis of substrate recognition and the catalytic mechanism of the mannosyltransferase PimE, which is crucial for the biosynthesis of phosphatidyl-myo-inositol mannosides (PIMs) in Mycobacterium tuberculosis.

Yaqi Liu
Chelsea M. Brown
Filippo Mancia
ResearchOpen Access29 Apr 2025
Nature Communications

Volume: 16, P: 1-17
Assessing the diagnostic impact of blood transcriptome profiling in a pediatric cohort previously assessed by genome sequencing

Huayun Hou
Kyoko E. Yuki
Lianna Kyriakopoulou
ResearchOpen Access01 Jul 2025
npj Genomic Medicine

Volume: 10, P: 1-13
Catalase activity deficiency sensitizes multidrug-resistant Mycobacterium tuberculosis to the ATP synthase inhibitor bedaquiline

Multidrug-resistant (MDR) tuberculosis threatens global control of tuberculosis disease. Here, the authors investigate mechanisms underlying the collateral sensitivity of MDR Mycobacterium tuberculosis to the ATP synthase inhibitor bedaquiline.

Boatema Ofori-Anyinam
Meagan Hamblin
Jason H. Yang
ResearchOpen Access13 Nov 2024
Nature Communications

Volume: 15, P: 1-13
Host-microbe multiomic profiling identifies distinct COVID-19 immune dysregulation in solid organ transplant recipients

Solid organ transplant recipients are at increased risk of infectious disease and have unique molecular pathophysiology. Here the authors use host-microbe profiling to assess SARS-CoV-2 infection and immunity in solid organ transplant recipients, showing enhanced viral abundance, impaired clearance, and increased expression of innate immunity genes.

Harry Pickering
Joanna Schaenman
Charles R. Langelier
ResearchOpen Access10 Jan 2025
Nature Communications

Volume: 16, P: 1-16
Click processes orthogonal to CuAAC and SuFEx forge selectively modifiable fluorescent linkers

Orthogonal click reactions enable the rapid assembly of molecules of all sizes. Now, it has been shown that a nitrile, an allene, a diborane and a hydrazine or aniline can be catalytically merged in a click process that is orthogonal to SuFEx and CuAAC, delivering fluorescent linkages.

Paulo H. S. Paioti
Katherine E. Lounsbury
Amir H. Hoveyda
Research13 Dec 2023
Nature Chemistry

Volume: 16, P: 426-436
Repeated cross-sectional sero-monitoring of SARS-CoV-2 in New York City

Seropositive samples of SARS-CoV-2 were detected as early as mid-February in patients at Mount Sinai Hospital in New York City, and antibody positivity increased during the first wave of the pandemic and remained stable afterwards.

Daniel Stadlbauer
Jessica Tan
Florian Krammer
Research03 Nov 2020
Nature

Volume: 590, P: 146-150
The clinical utility of integrative genomics in childhood cancer extends beyond targetable mutations

Shlien and colleagues report on 300 patients from the SickKids Cancer Sequencing program and identify clinically actionable variants in 56% of the patients by profiling somatic and germline data at multiple clinical time points.

Anita Villani
Scott Davidson
Adam Shlien
ResearchOpen Access30 Dec 2022
Nature Cancer

Volume: 4, P: 203-221
Antibodies targeting the neuraminidase active site inhibit influenza H3N2 viruses with an S245N glycosylation site

Antibodies that broadly inhibit influenza virus neuraminidase by binding to its active site could be therapeutic candidates, but circulating viruses have acquired a glycosylation site in that region. Here, the authors show that, while the S245N glycosylation site affects binding of tested monoclonal antibodies, protective activity in a mouse model is maintained.

Daniel Stadlbauer
Meagan McMahon
Florian Krammer
ResearchOpen Access21 Dec 2022
Nature Communications

Volume: 13, P: 1-8
Stakeholder integration predicts better outcomes from groundwater sustainability policy

This paper shows that integrating diverse stakeholders into management plans results in better protection, especially for those most vulnerable to the impacts of natural resource depletion.

Debra Perrone
Melissa M. Rohde
E. J. Remson
ResearchOpen Access27 Jun 2023
Nature Communications

Volume: 14, P: 1-14
Disulfiram induces redox imbalance and perturbations in central glucose catabolism and metal homeostasis to inhibit the growth of Staphylococcus aureus

Timothy E. Long
Surya Teja Naidu
Monica A. Valentovic
ResearchOpen Access05 May 2025
Scientific Reports

Volume: 15, P: 1-15
Trans-mitochondrial coordination of cristae at regulated membrane junctions

Mammalian mitochondria are capable of inter-organelle communication, but connections between mitochondria have not been defined. Here, Picard et al. report the presence of inter-mitochondrial junctions, electron-dense regions with coordinated inner membrane cristae that do not depend on mitofusins for their formation.

Martin Picard
Meagan J. McManus
Douglas C. Wallace
ResearchOpen Access17 Feb 2015
Nature Communications

Volume: 6, P: 1-8
Structural basis of peptidoglycan synthesis by E. coli RodA-PBP2 complex

Bacterial cell shape is dependent on the formation of the extracellular sugar polymer called peptidoglycan. Here the authors describe RodA-PBP2, the enzymatic core of the elongasome, which is the complex responsible peptidoglycan synthesis, and utilize an integrated approach to investigate the mechanism of peptidoglycan biosynthesis.

Rie Nygaard
Chris L. B. Graham
Filippo Mancia
ResearchOpen Access24 Aug 2023
Nature Communications

Volume: 14, P: 1-15
Effect of dimethyl fumarate on mitochondrial metabolism in a pediatric porcine model of asphyxia-induced in-hospital cardiac arrest

Sarah Piel
Meagan J. McManus
Todd J. Kilbaugh
ResearchOpen Access15 Jun 2024
Scientific Reports

Volume: 14, P: 1-15
Optimized sgRNA design to maximize activity and minimize off-target effects of CRISPR-Cas9

Genome-wide sgRNA libraries based on rules for on-target activity improve results of Cas9-based screens and facilitate a further refinement of on- and off-target prediction algorithms.

John G Doench
Nicolo Fusi
David E Root
Research18 Jan 2016
Nature Biotechnology

Volume: 34, P: 184-191
Structural basis of lipopolysaccharide maturation by the O-antigen ligase

Cryo-electron microscopy structures of the bacterial O-antigen ligase WaaL, combined with genetics, biochemistry and molecular dynamics simulations, provide insight into the mechanism by which WaaL catalyses the biosynthesis of lipopolysaccharide.

Khuram U. Ashraf
Rie Nygaard
Filippo Mancia
Research06 Apr 2022
Nature

Volume: 604, P: 371-376
Irreversible electroporation augments checkpoint immunotherapy in prostate cancer and promotes tumor antigen-specific tissue-resident memory CD8+ T cells

Irreversible electroporation (IRE), a soft-tissue ablation technique used for tumour ablation, has been suggested to promote systemic immune responses. Here the authors show that IRE, followed by anti-CTLA-4 blockade, elicits the expansion of tumor antigen-specific CD8+ T cells and is associated with tissue residency and improved anti-tumor immune response in a preclinical model of prostate cancer.

Brandon J. Burbach
Stephen D. O’Flanagan
Yoji Shimizu
ResearchOpen Access23 Jun 2021
Nature Communications

Volume: 12, P: 1-16
Optimized libraries for CRISPR-Cas9 genetic screens with multiple modalities

Genome-wide libraries for CRISPR knockout, interference, and activation have allowed the systemic interrogation of gene function. Here, the authors evaluate the Brunello CRISPRko library and introduce Dolcetto and Calabrese for CRISPRi and CRISPRa, respectively.

Kendall R. Sanson
Ruth E. Hanna
John G. Doench
ResearchOpen Access21 Dec 2018
Nature Communications

Volume: 9, P: 1-15
Transcriptional profiling links unique human macrophage phenotypes to the growth of intracellular Salmonella enterica serovar Typhi

Ruth Schade
Daniel S. C. Butler
Denise M. Monack
ResearchOpen Access04 Jun 2024
Scientific Reports

Volume: 14, P: 1-15
CRISPR/Cas9 screens identify key host factors that enhance rotavirus reverse genetics efficacy and vaccine production

Yinxing Zhu
Meagan E. Sullender
Siyuan Ding
ResearchOpen Access06 Nov 2024
npj Vaccines

Volume: 9, P: 1-12
Introducing a sleep disorder screening and management strategy for workers with future shift work requirements: a feasibility and acceptability study

Brandon W. J. Brown
Robert J. Adams
Amy C. Reynolds
ResearchOpen Access28 Aug 2024
Scientific Reports

Volume: 14, P: 1-12
Genome-wide association study identifies novel breast cancer susceptibility loci

Previous work has identified several genes where mutations lead to breast cancer, but other genetic and environmental factors must still be accounted for. A large study of genetic association with breast cancer points to four novel genes and many more genetic markers that should be pursued for their link to cancer susceptibility.

Douglas F. Easton
Karen A. Pooley
Bruce A. J. Ponder
Research28 Jun 2007
Nature

Volume: 447, P: 1087-1093
OxPhos defects cause hypermetabolism and reduce lifespan in cells and in patients with mitochondrial diseases

A meta-analysis of 17 cohorts of mitochondrial disease patients reveals that OxPhos defects are associated with signs of hypermetabolism. Experiments in patient-derived fibroblast show that mitochondrial OxPhos defects trigger hypermetabolism in a cell-autonomous manner and this is linked to accelerated telomere shortening and epigenetic aging.

Gabriel Sturm
Kalpita R. Karan
Martin Picard
ResearchOpen Access12 Jan 2023
Communications Biology

Volume: 6, P: 1-22
Rational design of highly active sgRNAs for CRISPR-Cas9–mediated gene inactivation

Analysis of the genome editing activity of more than 1800 sgRNAs in mouse and human cells yields rules to facilitate design of highly active RNA guides for Cas-9 genome editing.

John G Doench
Ella Hartenian
David E Root
Research03 Sept 2014
Nature Biotechnology

Volume: 32, P: 1262-1267
RETRACTED ARTICLE: A mechanism for the suppression of homologous recombination in G1 cells

A mechanism for the repression of homologous recombination in G1, the stage of the cell cycle preceding replication, is determined; the critical aspects are the interaction between BRCA1 and PALB2–BRCA2, and suppression of DNA-end resection.

Alexandre Orthwein
Sylvie M. Noordermeer
Daniel Durocher
Research09 Dec 2015
Nature

Volume: 528, P: 422-426
RIG-like Helicase Regulation of Chitinase 3-like 1 Axis and Pulmonary Metastasis

Bing Ma
Erica L. Herzog
Jack A. Elias
ResearchOpen Access20 May 2016
Scientific Reports

Volume: 6, P: 1-13
Modeling dynamic interactions between pre-exposure prophylaxis interventions & treatment programs: predicting HIV transmission & resistance

Virginie Supervie
Meagan Barrett
Sally Blower
ResearchOpen Access07 Dec 2011
Scientific Reports

Volume: 1, P: 1-12
Succinate prodrugs in combination with atropine and pralidoxime protect cerebral mitochondrial function in a rodent model of acute organophosphate poisoning

Sarah Piel
Joanna I. Janowska
Todd J. Kilbaugh
ResearchOpen Access25 Nov 2022
Scientific Reports

Volume: 12, P: 1-11
Combined agonists act synergistically to increase mucociliary clearance in a cystic fibrosis airway model

Nam Soo Joo
Hyung-Ju Cho
Jeffrey J. Wine
ResearchOpen Access22 Sept 2021
Scientific Reports

Volume: 11, P: 1-13
Immunogenicity of NVX-CoV2373 heterologous boost against SARS-CoV-2 variants

Kirsten E. Lyke
Robert L. Atmar
Jennifer A. Whitaker
ResearchOpen Access11 Jul 2023
npj Vaccines

Volume: 8, P: 1-10
Shift work, clinically significant sleep disorders and mental health in a representative, cross-sectional sample of young working adults

Amy C. Reynolds
Bastien Lechat
Peter R. Eastwood
ResearchOpen Access28 Sept 2022
Scientific Reports

Volume: 12, P: 1-8
Mendelian randomisation study of smoking exposure in relation to breast cancer risk

Hanla A. Park
Sonja Neumeyer
Jenny Chang-Claude
ResearchOpen Access02 Aug 2021
British Journal of Cancer

Volume: 125, P: 1135-1145
CYP3A7*1C allele: linking premenopausal oestrone and progesterone levels with risk of hormone receptor-positive breast cancers

Nichola Johnson
Sarah Maguire
Olivia Fletcher
ResearchOpen Access26 Jan 2021
British Journal of Cancer

Volume: 124, P: 842-854
Accuracy and Precision of Tidal Wetland Soil Carbon Mapping in the Conterminous United States

James R. Holmquist
Lisamarie Windham-Myers
Mark Woodrey
ResearchOpen Access21 Jun 2018
Scientific Reports

Volume: 8, P: 1-16
An open resource for transdiagnostic research in pediatric mental health and learning disorders

Lindsay M. Alexander
Jasmine Escalera
Michael P. Milham
ResearchOpen Access19 Dec 2017
Scientific Data

Volume: 4, P: 1-26
FANCM missense variants and breast cancer risk: a case-control association study of 75,156 European women

Gisella Figlioli
Amandine Billaud
Paolo Peterlongo
ResearchOpen Access27 Jan 2023
European Journal of Human Genetics

Volume: 31, P: 578-587
Author Correction: Accuracy and Precision of Tidal Wetland Soil Carbon Mapping in the Conterminous United States

James R. Holmquist
Lisamarie Windham-Myers
Mark Woodrey
Amendments and CorrectionsOpen Access09 Oct 2018
Scientific Reports

Volume: 8, P: 1-2
Development and validation of a targeted gene sequencing panel for application to disparate cancers

Mark J. McCabe
Marie-Emilie A. Gauthier
Mary-Anne Young
ResearchOpen Access19 Nov 2019
Scientific Reports

Volume: 9, P: 1-16
The FANCM:p.Arg658* truncating variant is associated with risk of triple-negative breast cancer

Gisella Figlioli
Massimo Bogliolo
Paolo Peterlongo
ResearchOpen Access01 Nov 2019
npj Breast Cancer

Volume: 5, P: 1-14
Endpoint surrogacy in oncology Phase 3 randomised controlled trials

Jianrong Zhang
Meagan R. Pilar
Jianxing He
Editorial26 May 2020
British Journal of Cancer

Volume: 123, P: 333-334

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