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Showing 1–3 of 3 results
Advanced filters: Author: Mehman Bunyatov Clear advanced filters

  • While enzyme-mediated oligosaccharide synthesis is versatile, it is often limited by the availability of glycosyl transferases. Now a chemoenzymatic strategy is reported, comprising enzymatic assembly of a core oligosaccharide followed by chemical manipulations, to produce a library of glycans that reveal binding specificities of serum antibodies.

    • Mehman Bunyatov
    • Margreet A. Wolfert
    • Geert-Jan Boons
    Research
    Nature Synthesis
    Volume: 3, P: 85-98

  • The recently identified Wuhan spiny eel influenza virus (WSEIV) sequence is more closely related to influenza B than A viruses. Here, the authors functionally characterize the putative surface glycoproteins of WSEIV and show that its NA-like protein has sialidase activity and its HA-like protein binds monosialic ganglioside 2.

    • Guha Asthagiri Arunkumar
    • Disha Bhavsar
    • Florian Krammer
    ResearchOpen Access
    Nature Communications
    Volume: 12, P: 1-12

  • The specificity of human and animal viruses that engage with O-acetylated sialic acids has now been probed using a collection of O-acetylated sialoglycans obtained by diversification of trisaccharide precursors with viral haemagglutinin–esterases. The results revealed host-specific patterns of receptor recognition and showed that human respiratory viruses uniquely employ 9-O-acetylated α2,8-linked disialosides as receptors.

    • Zeshi Li
    • Yifei Lang
    • Geert-Jan Boons
    Research
    Nature Chemistry
    Volume: 13, P: 496-503