Nature Search

Serpina3k lactylation protects from cardiac ischemia reperfusion injury

Lactylation of proteins has been shown to carry diverse roles during cardiac reperfusion injury. Here, the authors show that lactylated Serpina3k/SERPINA3 secreted from fibroblasts during reperfusion protects cardiomyocytes from apoptosis in a paracrine fashion.

Le Wang
Dandan Li
Bingying Zhou
ResearchOpen Access25 Jan 2025
Nature Communications

Volume: 16, P: 1-21
Superconductivity above 200 K discovered in superhydrides of calcium

The discovery of superconductivity in hydrides at critical temperature (T_c) near room temperature receives intensive attentions. Here the authors report experimental synthesis and discovery of superconductivity with T_c above 210 K in calcium superhydrides at 160–190 GPa.

Zhiwen Li
Xin He
Changqing Jin
ResearchOpen Access23 May 2022
Nature Communications

Volume: 13, P: 1-5
TGFBI Gene Mutation Analysis of Clinically Diagnosed Granular Corneal Dystrophy Patients Prior to PTK: A Pilot Study from Eastern China

Li Zeng
Jing Zhao
Xingtao Zhou
ResearchOpen Access04 Apr 2017
Scientific Reports

Volume: 7, P: 1-5
Lin28B-high breast cancer cells promote immune suppression in the lung pre-metastatic niche via exosomes and support cancer progression

The establishment of a pre-metastatic niche is a key step preceding metastasis formation. Here the authors show that tumor-intrinsic Lin28B, a RNA-binding protein, has an essential role in the formation of an immune-suppressive pre-metastatic niche, promoting lung metastasis of breast cancer.

Meiyan Qi
Yun Xia
Lixing Zhan
ResearchOpen Access16 Feb 2022
Nature Communications

Volume: 13, P: 1-18
Nanostructures/TiN layer/Al₂O₃ layer/TiN substrate configuration-based high-performance refractory metasurface solar absorber

Pei Zeng
Yuting Zhou
Mengjie Zheng
ResearchOpen Access28 Oct 2024
Scientific Reports

Volume: 14, P: 1-12
Brusatol sensitizes endometrial hyperplasia and cancer to progestin by suppressing NRF2-TET1-AKR1C1-mediated progestin metabolism

For precancerous/endometrial cancer patients with fertility maintain desire, progestin resistance is the main obstacle of conservative therapy. The authors found that brusatol, as a natural compound, suppresses progestin metabolism through regulating the NRF2-TET1-AKR1C1 pathway to sensitize precancerous/endometrial cancers to progestin and relieve progestin resistance. This study indicates that progestin combined with brusatol may enhance the treatment effects and that AKR1C1 expression patterns may serve as an important biomarker of progestin resistance in endometrial cancer.

Meiyan Hu
Di Sun
Zhenbo Zhang
Research29 Aug 2022
Laboratory Investigation

Volume: 102, P: 1335-1345
Isoflurane preconditioning provides neuroprotection against stroke by regulating the expression of the TLR4 signalling pathway to alleviate microglial activation

Meiyan Sun
Bin Deng
Xude Sun
ResearchOpen Access18 Jun 2015
Scientific Reports

Volume: 5, P: 1-14
Hippocampus Segmentation Based on Local Linear Mapping

Shumao Pang
Jun Jiang
Qianjin Feng
ResearchOpen Access03 Apr 2017
Scientific Reports

Volume: 7, P: 1-11
MicroRNA-375 is a therapeutic target for castration-resistant prostate cancer through the PTPN4/STAT3 axis

Junqing Gan
Shan Liu
Xiaoyi Huang
ResearchOpen Access30 Aug 2022
Experimental & Molecular Medicine

Volume: 54, P: 1290-1305
The IAA- and ABA-responsive transcription factor CgMYB58 upregulates lignin biosynthesis and triggers juice sac granulation in pummelo

Meiyan Shi
Xiao Liu
Juan Xu
ResearchOpen Access01 Sept 2020
Horticulture Research

Volume: 7, P: 1-14
Longitudinal measurement and hierarchical classification framework for the prediction of Alzheimer’s disease

Meiyan Huang
Wei Yang
Kristin Fargher
ResearchOpen Access12 Jan 2017
Scientific Reports

Volume: 7, P: 1-13

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