Nature Search

Sensing ceramides by CYSLTR2 and P2RY6 to aggravate atherosclerosis

CYSLTR2 and P2RY6 are identified as endogenous ceramide receptors, and inhibition of these ameliorates atherosclerosis, particularly in chronic-kidney-disease-associated cardiovascular disease.

Siting Zhang
Hui Lin
Wei Kong
Research06 Mar 2025
Nature

Volume: 641, P: 476-485
MyoD is a 3D genome structure organizer for muscle cell identity

Pioneer transcription factors (TFs) have been proposed to act as protein anchors to orchestrate cell type-specific 3D genome architecture. MyoD is a pioneer TF for myogenic lineage specification. Here the authors provide further support for the role of MyoD in 3D genome architecture in muscle stem cells by comparing MyoD knockout and wild-type mice.

Ruiting Wang
Fengling Chen
Dahai Zhu
ResearchOpen Access11 Jan 2022
Nature Communications

Volume: 13, P: 1-17
Onset age moderates the associations between neutrophil-to-lymphocyte ratio and clinical symptoms in first-episode patients with schizophrenia

Kuiyuan Wang
Shaohua Liu
Yuanyuan Huang
ResearchOpen Access19 Nov 2024
Schizophrenia

Volume: 10, P: 1-5
Efficacy of the tetravalent protein COVID-19 vaccine, SCTV01E: a phase 3 double-blind, randomized, placebo-controlled trial

Here, the authors report results from a randomized, placebo-controlled phase 3 trial of the tetravalent SARS-CoV-2 protein vaccine SCTV01E, demonstrating a favorable efficacy profile during a time when predominant viral variants were changing from BA.5 and BF.7 to XBB.

Ruizhi Zhang
Junshi Zhao
Liangzhi Xie
ResearchOpen Access24 Jul 2024
Nature Communications

Volume: 15, P: 1-11
Skeletal muscle-secreted DLPC orchestrates systemic energy homeostasis by enhancing adipose browning

MyoD is a transcription factor expressed in skeletal muscle that plays a critical role in determining myogenic cell fate. Here, Hu et al. reveal a metabolic role of MyoD in orchestrating systemic energy homeostasis by mediating muscle-fat crosstalk through the muscle-secreted lipokine DLPC.

Xiaodi Hu
Mingwei Sun
Dahai Zhu
ResearchOpen Access30 Nov 2023
Nature Communications

Volume: 14, P: 1-18
High-quality genome of a modern soybean cultivar and resequencing of 547 accessions provide insights into the role of structural variation

High-quality genome of the modern soybean cultivar Nongdadou2 and deep resequencing of 547 accessions provide insights into the role of structural variations in soybean improvement.

Caiying Zhang
Zhenqi Shao
Xihuan Li
Research09 Sept 2024
Nature Genetics

Volume: 56, P: 2247-2258
Genetic regulators of large-scale transcriptional signatures in cancer

Adam S Adler
Meihong Lin
Howard Y Chang
Research05 Mar 2006
Nature Genetics

Volume: 38, P: 421-430
Pre-operative exercise therapy triggers anti-inflammatory trained immunity of Kupffer cells through metabolic reprogramming

Zhang et al. show that pre-operative exercise protects against liver injury by driving Kupffer cells towards an anti-inflammatory phenotype via itaconate metabolism.

Hongji Zhang
Tianmeng Chen
Hai Huang
Research14 Jun 2021
Nature Metabolism

Volume: 3, P: 843-858
Efficacy of standard operating procedures for fall protection in hospitalized patients with schizophrenia

Hui Li
Caixing Liu
Zezhi Li
ResearchOpen Access17 Oct 2023
Schizophrenia

Volume: 9, P: 1-6
Genomic evidence of human selection on Vavilovian mimicry

Vavilovian mimicry is the phenomenon whereby weeds evolve to resemble co-located crop plants through unintentional human selection. Here the authors compare mimetic and non-mimetic populations of Echinochloa crus-galli (a weed mimic of rice) to characterize the genomic underpinnings of this case of Vavilovian mimicry.

Chu-Yu Ye
Wei Tang
Longjiang Fan
Research16 Sept 2019
Nature Ecology & Evolution

Volume: 3, P: 1474-1482
Long non-coding RNA Linc-RAM enhances myogenic differentiation by interacting with MyoD

Long non-coding RNAs are important regulators of many diverse biological processes. Here the authors describe Linc-RAM, which regulates myogenesis by binding MyoD and promoting the assembly of the MyoD–Baf60c–Brg1 complex at target genes.

Xiaohua Yu
Yong Zhang
Dahai Zhu
ResearchOpen Access16 Jan 2017
Nature Communications

Volume: 8, P: 1-12
MD2 activation by direct AGE interaction drives inflammatory diabetic cardiomyopathy

The mechanisms underlying cardiac inflammation in diabetic cardiomyopathy are incompletely understood. Here the authors show that advanced glycation end products bind to the TLR4 co-receptor MD2 initiating pro-inflammatory pathways.

Yi Wang
Wu Luo
Guang Liang
ResearchOpen Access01 May 2020
Nature Communications

Volume: 11, P: 1-16
Serum Golgi protein 73 is a marker comparable to APRI for diagnosing significant fibrosis in children with liver disease

Langli Liu
Jianwen Wang
Jian-She Wang
ResearchOpen Access13 Nov 2018
Scientific Reports

Volume: 8, P: 1-7
Treatment response prediction and individualized identification of first-episode drug-naïve schizophrenia using brain functional connectivity

Bo Cao
Raymond Y. Cho
Xiang Yang Zhang
Research19 Jun 2018
Molecular Psychiatry

Volume: 25, P: 906-913
Ferroelectricity and Self-Polarization in Ultrathin Relaxor Ferroelectric Films

Peixian Miao
Yonggang Zhao
Qiang Li
ResearchOpen Access28 Jan 2016
Scientific Reports

Volume: 6, P: 1-9
Sintilimab (anti-PD-1 antibody) combined with high-dose methotrexate, temozolomide, and rituximab (anti-CD20 antibody) in primary central nervous system lymphoma: a phase 2 study

Zhiyong Zeng
Apeng Yang
Junmin Chen
ResearchOpen Access04 Sept 2024
Signal Transduction and Targeted Therapy

Volume: 9, P: 1-10
Structure and drug binding of the SARS-CoV-2 envelope protein transmembrane ___domain in lipid bilayers

A solid-state NMR structure of the transmembrane ___domain from SARS-CoV-2 envelope protein in the phospholipid environment reveals determinants of cation selectivity, a dehydrated pore and an N-terminal drug-binding site.

Venkata S. Mandala
Matthew J. McKay
Mei Hong
Research11 Nov 2020
Nature Structural & Molecular Biology

Volume: 27, P: 1202-1208
Spermidine-eIF5A axis is essential for muscle stem cell activation via translational control

Qianying Zhang
Wanhong Han
Hu Li
ResearchOpen Access10 Sept 2024
Cell Discovery

Volume: 10, P: 1-19
Hydrogen protects lung from hypoxia/re-oxygenation injury by reducing hydroxyl radical production and inhibiting inflammatory responses

Meihong Chen
Jie Zhang
Dongbo Tian
ResearchOpen Access22 May 2018
Scientific Reports

Volume: 8, P: 1-12
Endothelial adenosine A2a receptor-mediated glycolysis is essential for pathological retinal angiogenesis

Pathological angiogenesis in the retina is a major cause of blindness. Here the authors show that adenosine receptor A2A drives pathological angiogenesis in the oxygen-induced retinopathy mouse model by promoting glycolysis in endothelial cells via the ERK/Akt/HIF-1α pathway, thereby suggesting new therapeutic targets for disease treatment.

Zhiping Liu
Siyuan Yan
Yuqing Huo
ResearchOpen Access19 Sept 2017
Nature Communications

Volume: 8, P: 1-18
Cysteine protease inhibitor 1 promotes metastasis by mediating an oxidative phosphorylation/MEK/ERK axis in esophageal squamous carcinoma cancer

Liangming Zhang
Xiongfeng Chen
Yi Huang
ResearchOpen Access29 Feb 2024
Scientific Reports

Volume: 14, P: 1-16
Mechanical response of long-span CFST arch bridges based on the hydration heat temperature effect

Yuexing Wu
Qiang Wen
Xianliang Tan
ResearchOpen Access25 Jun 2024
Scientific Reports

Volume: 14, P: 1-16
Bioinformatic analysis reveals the importance of epithelial-mesenchymal transition in the development of endometriosis

Meihong Chen
Yilu Zhou
Yihua Wang
ResearchOpen Access21 May 2020
Scientific Reports

Volume: 10, P: 1-12
Paeonol attenuates inflammation by targeting HMGB1 through upregulating miR-339-5p

Liyan Mei
Meihong He
Hui Li
ResearchOpen Access18 Dec 2019
Scientific Reports

Volume: 9, P: 1-15
Correction: Glucose disturbances, cognitive deficits and white matter abnormalities in first-episode drug-naive schizophrenia

Xiangyang Zhang
Mi Yang
Huafu Chen
Amendments and Corrections22 Oct 2019
Molecular Psychiatry

Volume: 25, P: 3454
Oncolytic measles virus enhances antitumour responses of adoptive CD8⁺NKG2D⁺ cells in hepatocellular carcinoma treatment

Aiping Chen
Yonghui Zhang
Jiwu Wei
ResearchOpen Access12 Jul 2017
Scientific Reports

Volume: 7, P: 1-13
Glucose disturbances, cognitive deficits and white matter abnormalities in first-episode drug-naive schizophrenia

Xiangyang Zhang
Mi Yang
Huafu Chen
Research13 Aug 2019
Molecular Psychiatry

Volume: 25, P: 3220-3230
Exosomal circRELL1 serves as a miR-637 sponge to modulate gastric cancer progression via regulating autophagy activation

Huaiming Sang
Weifeng Zhang
Guoxin Zhang
ResearchOpen Access13 Jan 2022
Cell Death & Disease

Volume: 13, P: 1-11
Targeting aerobic glycolysis by dichloroacetate improves Newcastle disease virus-mediated viro-immunotherapy in hepatocellular carcinoma

Gang Meng
Binghua Li
Jiwu Wei
ResearchOpen Access10 Dec 2019
British Journal of Cancer

Volume: 122, P: 111-120
Sex difference in association of symptoms and white matter deficits in first-episode and drug-naive schizophrenia

Xiao-E Lang
Daomin Zhu
Xiang Yang Zhang
ResearchOpen Access18 Dec 2018
Translational Psychiatry

Volume: 8, P: 1-8
BMP7 retards peripheral myelination by activating p38 MAPK in Schwann cells

Xiaoyu Liu
Yahong Zhao
Cheng Sun
ResearchOpen Access05 Aug 2016
Scientific Reports

Volume: 6, P: 1-13

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