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Pairing center (PC) on each chromosome are crucial for homolog pairing and initiating synapsis in Caenorhabditis elegans. Here the authors investigate how the meiosis-specific proteins: ZIM/HIM-8 family recognize their cognate PC DNA motifs.

The uneven surfaces of copper indium gallium selenide (CIGS) solar cells pose challenges for depositing the upper layers in flexible perovskite/CIGS tandem solar cells. Ying et al. tackle this issue using an antisolvent and seeding strategy, resulting in a certified efficiency of 23.8%.

The importance of STAT5 tyrosine phosphorylation on T cells has not been investigated in vivo. Here the authors generate STAT5A and STAT5B tyrosine mutant knockin mice and show that Stat5a/b tyrosine is required for maximal IL-2 signaling and CD8 + T cell proliferation.

Aneuploidy is associated with cancer metastasis, but the causal relationship between them is unclear. Here the authors show that aneuploid murine embryonic stem cells lead to teratomas that can spread to multiple organs without requiring additional driver gene mutations and identify unique cell populations with high stemness in aneuploid teratomas.

Zhou et. al. report the interim results of the randomized phase III GEMSTONE-302 trial, showing the overall survival benefits of first-line treatment with the PD-L1 inhibitor sugemalimab versus placebo in combination with chemotherapy, in patients with NSCLC.

The combination of anti-PD-1 treatment with cisplatin and 5-fluorouracil in patients with previously untreated, PD-L1-positive esophageal squamous cell carcinoma improved progression-free survival and overall survival.

Whole-genome resequencing of 418 diverse rapeseed accessions and genome-wide association analyses for 56 agronomic traits provide insights into the genetic architecture and artificial selection or adaptation during modern rapeseed breeding.

Targeted protein degradation (TPD) is a key modality for drug discovery. Here the authors present the discovery and analysis of reversible DCAF1-PROTACs, which show efficacy in cellular environments resistant to VHL-PROTACs or with acquired resistance to CRBN-PROTACs.

Cold-induced activation of thermogenesis in white adipose tissue (WAT), or ‘beiging’, is associated with WAT angiogenesis. Here the authors show that PDGF-CC is secreted from endothelial cells in the context of WAT angiogenesis and its paracrine action on adipocytes contributes to cold-induced beiging.

Histamine mediates allergic reactions, inflammation, wakefulness, gastric acid secretion and neurotransmission, among others. Here, the authors determine 9 cryo-EM structures of the 4 histamine receptors in complexes with four different G protein subtypes, with endogenous or synthetic agonists bound, revealing their distinct features.

Structure of PSII-CAC from cryptophyte Rhodomonas salina reveals a distinct organization of CACs and the presence of CAL-II, which may play a critical role in stabilizing the dimeric PSII-CAC complex under stress conditions.

Cassava is a major source of food in tropical and subtropical regions. Here the authors sequence the genomes of wild and domesticated cassava varieties and identify genes that have been selected for and against during the evolution and domestication of this economically important crop.

Here, the authors present structural and mechanistic characterisation of the UDP-dependent glycosyltransferase SgUGT94-289-3, which generates two mogrosides of interest as natural sweeteners. Structure-based engineering yielded variants with improved specificity and activity.

The sphingosine-1-phosphate receptor 1 mediates the inhibitory effect of eicosapentaenoic acid on endothelial activation and atherogenesis, furthering our understanding of the cardioprotective role of omega-3 polyunsaturated fatty acids.

The cryo-electron microscopy structure of the GPR101–Gs complex reveals the mechanism for its constitutive activity and facilitates the screening and identification of GPR101 ligands with rejuvenating potential.

Many biological processes require the movement of cells in response to guidance cues. Small GTPases and phosphoinositides are key mediators of the underlying cytoskeletal rearrangements, and a new study establishes that the localization and activation of the phosphoinositide phosphatase PTEN at the rear of chemotaxing neutrophils is mediated by the small GTPase RhoA.

High-resolution structures of the PSI–LHCI–LHCII supercomplex from Chlamydomonas reinhardtii reveal the mechanism of assembly between the PSI–LHCI complex and two phosphorylated LHCII trimers.

Chromodomains mainly function as histone methyl-lysine readers to regulate gene expression. Here the authors delineate a functional map of chromodomain proteins and identify an H3K9me1/2 writer, MET-2, and reader, CEC-5, that are required for the normal lifespan of C. elegans.

Genetic, biochemical and high-resolution structural studies of chloroplast protein SOQ1 reveal the existence of a C-terminal lumenal ___domain with potential redox function and its essential role for suppressing photoprotection in plants.

Cryo-electron microscopy structures of mouse trace amine-associated receptor 9 reveals structural motifs involved in odorant ligand recognition, including a unique disulfide bond linking the N terminus to extracellular loop 2.

This study presents a comprehensive pipeline to profile transmembrane receptors involved in macrophage-driven inflammation in pancreatic islets during the onset of diabetes. The authors identify GPR132 as a mediator of macrophage-driven inflammation and find compounds that reduce inflammation and improve glycaemic control.

The high-resolution structure of an Lhcb9-dependent PSI complex from Physcomitrium patens reveals the assembly details of this complex and the underlying mechanism by which P. patens switches between different types of PSI complex.

Bacterial photosynthesis reflects the early stages of the evolution of photosynthesis. Here, the authors present a systematic study of the cryo-EM structures of the dimeric light harvesting–reaction center complexes and assembly variants from Rhodobacter sphaeroides, which delineated a hierarchical assembly pathway and quinone transport routes of the dimeric photosynthetic RC–LH1 core complex.

Cyanobacterial photosystem I supercomplexes bind to iron-stress-induced proteins IsiA and flavodoxin under iron-deficiency conditions. They form a network that is highly efficient at light harvesting and retains normal electron transport efficiency.

PsbS is a transmembrane photosystem II protein essential for photoprotection in plants. Crystal structures show that PsbS is not a canonical pigment-binding protein and provide insights into its pH-dependent activation mechanism.

In Chlamydomonas reinhardtii, multiple units of light-harvesting complex I bind to the photosystem-I core, forming larger antennae than in plants. The structure, solved by cryo-electron microscopy, reveals details of antenna organization and functioning.

Acyl-acyl carrier protein reductase (AAR) and aldehyde deformylating oxygenase (ADO) are the two enzymes in a cyanobacterial alkane biosynthesis pathway that is of interest for biofuel production. Here the authors provide insights into the catalytic mechanisms of AAR and the coupling between the two enzymes by determining the crystal structures of AAR alone and three AAR–ADO complexes with various bound ligands.

NAD(P)H dehydrogenase-like complex NDH-1L couples the electron transport from ferredoxin (Fd) to plastoquinone (PQ) and proton pumping from cytoplasm to the lumen. Here authors report two structures of NDH-1L from Thermosynechococcus elongatus BP-1, in complex with one Fd and an endogenous PQ, respectively.

A high-resolution structural study sheds light on processes of energy transfer within the photosynthetic water-splitting machinery of plants.