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Mentoring the next generation of cell biologists

As Nature Cell Biology turns 25 years old, we asked cell biologists across the globe to share their thoughts on what a productive mentor–mentee relationship looks like and their views on training the next generation of cell biologists.

Derek A. Applewhite
Needhi Bhalla
Xiaochen Wang
Reviews16 Jan 2024
Nature Cell Biology

Volume: 26, P: 15-18
Correction: Publisher Correction: Simultaneous overactivation of Wnt/β-catenin and TGFβ signalling by miR-128-3p confers chemoresistance-associated metastasis in NSCLC

Junchao Cai
Lishan Fang
Mengfeng Li
Amendments and CorrectionsOpen Access30 Mar 2018
Nature Communications

Volume: 9, P: 1
AKT-induced lncRNA VAL promotes EMT-independent metastasis through diminishing Trim16-dependent Vimentin degradation

The role of long non-coding RNA (lncRNA) in AKT-driven tumor development is unclear. Here, the authors identify VAL (Vimentin associated lncRNA) to be directly induced by AKT/STAT3 signaling and report a lncRNA-mediated mechanism for active AKT-driven EMT-independent lung adenocarcinoma metastasis.

Han Tian
Rong Lian
Junchao Cai
ResearchOpen Access12 Oct 2020
Nature Communications

Volume: 11, P: 1-15
The IRENA lncRNA converts chemotherapy-polarized tumor-suppressing macrophages to tumor-promoting phenotypes in breast cancer

Song and colleagues report that in breast cancer, chemotherapy induces the IRENA lncRNA, which reprograms tumor suppressive macrophages to protumorigenic phenotypes and promotes chemoresistance.

Jiang Liu
Liyan Lao
Erwei Song
Research12 Apr 2021
Nature Cancer

Volume: 2, P: 457-473
An RFC4/Notch1 signaling feedback loop promotes NSCLC metastasis and stemness

Activated Notch signalling promotes cancer metastasis and stemness. Here the authors show that Notch1 activates transcription of DNA replication factor RCF4 and that RCF4 binds and stabilises Notch1 intracellular ___domain (NICD1) to promote cancer metastasis.

Lei Liu
Tianyu Tao
Han Tian
ResearchOpen Access11 May 2021
Nature Communications

Volume: 12, P: 1-16
Simultaneous overactivation of Wnt/β-catenin and TGFβ signalling by miR-128-3p confers chemoresistance-associated metastasis in NSCLC

Chemoresistance and metastasis are tightly associated features in non-small cell lung cancer (NSCLC). Here, the authors show that resistant NSCLCs have high levels of miR-128-3p which promotes EMT and cancer stem cell survival through the modulation of both Wnt/B-catenin and TGF-β pathway.

Junchao Cai
Lishan Fang
Mengfeng Li
ResearchOpen Access19 Jun 2017
Nature Communications

Volume: 8, P: 1-19
miR-508 sustains phosphoinositide signalling and promotes aggressive phenotype of oesophageal squamous cell carcinoma

The negative regulatory effects of phosphatases are sometimes altered in cancer, but the mechanisms that mediate this effect remain undefined. Here, the authors show that miR-508 suppresses multiple phosphatases, resulting in constitutive activation of the PI3K/Akt pathway.

Chuyong Lin
Aibin Liu
Libing Song
Research06 Aug 2014
Nature Communications

Volume: 5, P: 1-12
Genotoxic stress-triggered β-catenin/JDP2/PRMT5 complex facilitates reestablishing glutathione homeostasis

It is known that genotoxic stress induces high levels of ROS and deplete cellular glutathione stores. Here, Cao et al. uncover a β-catenin-dependent TCF/LEF-independent mechanism that promotes histone-mediated transcriptional activation of glutathione synthesis.

Lixue Cao
Geyan Wu
Jun Li
ResearchOpen Access21 Aug 2019
Nature Communications

Volume: 10, P: 1-17
Non-canonical NF-κB signalling and ETS1/2 cooperatively drive C250T mutant TERT promoter activation

The TERT promoter is mutated in many cancers. Li et al. show that non-canonical NF-κB signalling and ETS1/2 transcription factors are jointly needed to activate the C250T mutant TERT promoter, leading to telomerase activity and glioblastoma growth.

Yinghui Li
Qi-Ling Zhou
Vinay Tergaonkar
Research21 Sept 2015
Nature Cell Biology

Volume: 17, P: 1327-1338
A serum microRNA signature predicts trastuzumab benefit in HER2-positive metastatic breast cancer patients

Resistance to therapy is a significant issue for patients with metastatic breast cancer (MBC). Here the authors analyze total miRNA from serum samples of 386 MBC patients before treatment with a follow up of 31 months and define a four miRNA signature that predicts the therapeutic benefit of trastuzumab.

Huiping Li
Jiang Liu
Erwei Song
ResearchOpen Access24 Apr 2018
Nature Communications

Volume: 9, P: 1-13
CK1α suppresses lung tumour growth by stabilizing PTEN and inducing autophagy

Cai et al. show that CK1α suppresses lung cancer growth by inducing autophagy through a PTEN–AKT–FOXO3a pathway that ultimately leads to ATG7 expression.

Junchao Cai
Rong Li
Mengfeng Li
Research28 Mar 2018
Nature Cell Biology

Volume: 20, P: 465-478
Aberrantly expressed miR-582-3p maintains lung cancer stem cell-like traits by activating Wnt/β-catenin signalling

Despite the absence of frequent mutations of key components of Wnt/β-catenin signalling, this pathway is often constitutively activated in non-small cell lung carcinoma. In this study, the authors demonstrate the inhibitory effect of miR-582-3p on negative regulators of the Wnt/β-catenin pathway which is consequently triggered to sustain lung tumour growth.

Lishan Fang
Junchao Cai
Mengfeng Li
ResearchOpen Access15 Oct 2015
Nature Communications

Volume: 6, P: 1-15
Extracellular vesicle-packaged HIF-1α-stabilizing lncRNA from tumour-associated macrophages regulates aerobic glycolysis of breast cancer cells

Chen et al. show that tumour-associated macrophages transmit HIF-1α-stabilizing long noncoding RNA through extracellular vesicles to breast cancer cells, thereby enhancing tumour glycolysis and chemoresistance.

Fei Chen
Jianing Chen
Erwei Song
Research01 Apr 2019
Nature Cell Biology

Volume: 21, P: 498-510
Author Correction: miR-486 sustains NF-κB activity by disrupting multiple NF-κB-negative feedback loops

Libing Song
Chuyong Lin
Jun Li
Amendments and Corrections10 Aug 2021
Cell Research

Volume: 31, P: 1138
PHF14 enhances DNA methylation of SMAD7 gene to promote TGF-β-driven lung adenocarcinoma metastasis

Han Tian
Chenying Liu
Mengfeng Li
ResearchOpen Access18 Apr 2023
Cell Discovery

Volume: 9, P: 1-20
AKIP1 promotes early recurrence of hepatocellular carcinoma through activating the Wnt/β-catenin/CBP signaling pathway

Yanmei Cui
Xianqiu Wu
Libing Song
Research01 Apr 2019
Oncogene

Volume: 38, P: 5516-5529
EGF-induced nuclear localization of SHCBP1 activates β-catenin signaling and promotes cancer progression

Lei Liu
Yi Yang
Mengfeng Li
ResearchOpen Access03 Sept 2018
Oncogene

Volume: 38, P: 747-764
MYEOV functions as an amplified competing endogenous RNA in promoting metastasis by activating TGF-β pathway in NSCLC

Lishan Fang
Shanshan Wu
Hongyu Guan
ResearchOpen Access04 Sept 2018
Oncogene

Volume: 38, P: 896-912
Long non-coding RNA LEISA promotes progression of lung adenocarcinoma via enhancing interaction between STAT3 and IL-6 promoter

Shanshan Wu
Bangdong Liu
Hongyu Guan
Research15 Apr 2021
Oncogene

Volume: 40, P: 3449-3459
miR-486 sustains NF-κB activity by disrupting multiple NF-κB-negative feedback loops

Libing Song
Chuyong Lin
Jun Li
Research18 Dec 2012
Cell Research

Volume: 23, P: 274-289

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Mentoring the next generation of cell biologists

Correction: Publisher Correction: Simultaneous overactivation of Wnt/β-catenin and TGFβ signalling by miR-128-3p confers chemoresistance-associated metastasis in NSCLC

AKT-induced lncRNA VAL promotes EMT-independent metastasis through diminishing Trim16-dependent Vimentin degradation

The IRENA lncRNA converts chemotherapy-polarized tumor-suppressing macrophages to tumor-promoting phenotypes in breast cancer

An RFC4/Notch1 signaling feedback loop promotes NSCLC metastasis and stemness

Simultaneous overactivation of Wnt/β-catenin and TGFβ signalling by miR-128-3p confers chemoresistance-associated metastasis in NSCLC

miR-508 sustains phosphoinositide signalling and promotes aggressive phenotype of oesophageal squamous cell carcinoma

Genotoxic stress-triggered β-catenin/JDP2/PRMT5 complex facilitates reestablishing glutathione homeostasis

Non-canonical NF-κB signalling and ETS1/2 cooperatively drive C250T mutant TERT promoter activation

A serum microRNA signature predicts trastuzumab benefit in HER2-positive metastatic breast cancer patients

CK1α suppresses lung tumour growth by stabilizing PTEN and inducing autophagy

Aberrantly expressed miR-582-3p maintains lung cancer stem cell-like traits by activating Wnt/β-catenin signalling

Extracellular vesicle-packaged HIF-1α-stabilizing lncRNA from tumour-associated macrophages regulates aerobic glycolysis of breast cancer cells

Author Correction: miR-486 sustains NF-κB activity by disrupting multiple NF-κB-negative feedback loops

PHF14 enhances DNA methylation of SMAD7 gene to promote TGF-β-driven lung adenocarcinoma metastasis

AKIP1 promotes early recurrence of hepatocellular carcinoma through activating the Wnt/β-catenin/CBP signaling pathway

EGF-induced nuclear localization of SHCBP1 activates β-catenin signaling and promotes cancer progression

MYEOV functions as an amplified competing endogenous RNA in promoting metastasis by activating TGF-β pathway in NSCLC

Long non-coding RNA LEISA promotes progression of lung adenocarcinoma via enhancing interaction between STAT3 and IL-6 promoter

miR-486 sustains NF-κB activity by disrupting multiple NF-κB-negative feedback loops

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