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Relapsed and/or refractory acute myeloid leukemia (AML) postallogeneic hematopoietic cell transplantation has limited treatment options. Here the authors report the clinical results and immune correlates of a phase I/II trial of adoptively transferred virus-specific donor CD8 + T cells engineered to express a WT1-specific T cell receptor in patients with acute myeloid leukemia and active disease post-allogeneic hematopoietic cell transplantation.

Proteasomal degradation of cellular proteins generate defence peptides constitutively and in response to bacterial infection. Such peptides might provide a source of natural antibiotics that could lead to biotechnology applications and therapeutic interventions.

By integrating single-cell RNA and physically interacting cell sequencing analysis, here Cohen and colleagues report that neutrophils are enriched in physical crosstalk with breast tumor cells, promoting cancer aggressiveness.

PIC-seq characterizes cellular crosstalk by sorting and sequencing physically interacting cells.

Recreating the structural complexity of meat has been a major challenge in developing alternative proteins. Here, the authors present two injectable metamaterials that mimic the multi-scale properties of fat and muscle, enabling a cost-effective process for injection molding of whole cuts.

Merbl and colleagues demonstrate that high expression of the proteasome regulator PSME4 is associated with immune-cold lung tumors and reduced antitumor immune responses, by functioning to modulate the protein degradome and antigen diversity.

Multi-chambered vascularized human cardiac organoids produced under anisotropic stress and integrated with sensors facilitate the study of electro-metabolic coupling in arrythmia.

Through in vivo tracking of tumor-specific CD8⁺ T cells in response to immunotherapy in mice, Barboy et al. characterize the tumor response to anti-PD-1 therapy and optimize a combination treatment with anti-4-1BB agonist.

The culture of genetically unmodified human naive embryonic stem cells in specific growth conditions gives rise to structures that recapitulate those of post-implantation human embryos up to 13–14 days after fertilization.

A comprehensive spatial expression atlas of the adult human proximal small intestine reveals branched villi, immune activation at the villus tip, and a switch of migrating enterocytes from lipid droplet assembly and iron uptake at the villus bottom to chylomicron biosynthesis and iron release at the tip.

Nasal vaccination induces B cell expansion in the nasal-associated lymphoid tissues, followed by homing to the nasal turbinates and glandular acinar structures.

Amit and colleagues report that the specific interaction of a CD4⁺PD-1⁺CXCL13⁺ T-cell subset with antigen-presenting cells reprograms the tumor microenvironment and response to immune checkpoint inhibitors in non-small cell lung cancer.

Lieder et al show that individuals with dyslexia and individuals with ASD rely mostly on recent and earlier perceptual information, respectively, during perceptual tasks. This may explain the unique difficulties associated with the two conditions.

DestVI models continuous cell states in spatial transcriptomics data.

Single-cell analyses in a reporter mouse model and human tissues identify a rare cell subset that produces erythropoietin in vivo, opening potential new avenues for research in erythropoiesis and oxygen homeostasis.

Maturing erythroblasts become smaller with every cell division. Here, the authors show that Epo stimulation promotes cell division and also generates larger red cells, and that this occurs in mouse and human cells, suggesting that red cell size could be a diagnostic marker for hypoxic stress.

Single-cell analyses reveal cDC1 as conserved immunological drivers of non-alcoholic steatohepatitis in mice and humans

Multiomic analyses of mouse thymic epithelial cells identify several unconventional subsets that are mimetics of various populations of terminally differentiated parenchymal cells and provide insights into their development, molecular features and function.

The relationship between regulatory elements, chromatin interactions and gene expression during development remains poorly understood. Here the authors present Tiled-C, a low-input 3C approach to study genome architecture at high resolution, and apply it to mouse erythroid differentiation in vivo, finding that enhancer-promoter interactions are formed gradually during differentiation, concomitant with progressive upregulation of gene activity.

Correct Golgi assembly is important to cellular homeostasis but regulation of its structure under stress remains unclear. Here, the authors identify stress-induced degradation of GM130 by Golgi-localized 26S proteasomes, leading to Golgi dispersal.

Vaccination with multiple doses has been proven effective against severe COVID-19, but protection levels widely vary among individuals. This study examines the serological and immunological profiles in recipients of multiple doses of Pfizer BNT162b2 vaccine for immune markers that correlate with protection against and susceptibility for SARS-CoV-2 infection.

Patients with primary sclerosing cholangitis (PSC) harboring Klebsiella pneumoniae (Kp) exhibit poor clinical outcomes. Here, the authors show that administration of a phage cocktail targeting PSC-derived Kp reduces bacterial burden in Kp-colonized mice and alleviates liver injury.

Primary human hepatocytes are expanded in culture while retaining metabolic function.

G-protein coupled receptors are regulated by the membrane potential in vitro. Here, the authors show that muscarinic receptor voltage independence causes a strong behavioural effect of increased odour habituation, showing that these receptors are also in vivo modulated by the membrane potential.

A computational pipeline identifies tumor antigen post-translational modifications guiding immune responses.

This paper reports data of shot noise generated by the 5/2 fractional state in an ultraclean two-dimensional electron gas that compellingly points in the direction of the e/4 quasiparticles. It is believed that this observation is a first step towards understanding new fractional charges.

Glucocorticoids are released in a diurnal pattern. Here, the authors show that EGF receptor (EGFR) signalling is negatively regulated by glucocorticoids, and that EGFR inhibitor has stronger antitumour effects when administered during the resting phase, when glucocorticoids are low, offering potential optimization of cancer therapy regimens.

Donor-derived, EBV-specific CD8⁺ T cells engineered to express a high-affinity WT1-specific TCR established persistent T cell responses that safely prevented post-HCT relapse in patients with high-risk AML.

Combining the kinase inhibitor sorafenib with allogeneic stem cell transplantation boosts immune responses against a subtype of acute myelogenous leukemia, suggesting potential clinical benefit.

The authors show that Nlrp10 can form a functional inflammasome in vitro and ex vivo, and that this inflammasome is protective in dextran sodium sulfate-induced colitis in mice.