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Confining atoms to lattices can modify their interaction and collision. Here the authors show suppression of dipolar relaxation in the form of reduced decay rate of dysprosium atoms in quasi-2D regime.

Confined photoactivation of photoactivatable mCherry using two-photon illumination with line-scanning temporal focusing in combination with three-dimensional localization algorithms allows three-dimensional super-resolution microscopy of cellular features at <50 nm lateral and <100 nm axial resolution and depths greater than 8 μm.

Complex clinical samples can be imaged with 25 nm resolution using a light-emitting-diode-based wide-field microscope.

The authors report the measurement of the Little-Parks effect in the unconventional superconductor candidate 4Hb-TaS₂. They find a π-shift in the transition-temperature oscillations and an ehancement of T_c as a function of the out-of-plane field when a constant in-plane field is applied, consistent with a multi-component order parameter.

Memristive devices offer a future low-power solution to data storage and logic operations, but there is still a lack of suitable material design rules. Here, the authors present a design rule for retention-failure-resistant devices based on spectromicroscopic studies of strontium titanate.

As part of the first anniversary issue of Nature Chemical Engineering, we present a collection of opinions from 40 researchers within the field on what they think are the most exciting opportunities that lie ahead for their respective topics.

In most cancers, mutations that lead to oncogene activation and tumor suppressor inactivation synergize to promote tumorigenesis. However, in neuroblastomas, MYCN amplification and ATRX mutations are mutually exclusive and incompatible.

Drug combinations consisting of two cell death-targeting drugs are enriched for antagonism and ‘single-agent dominance’, where the faster-acting drug suppresses the slower-acting drug due to inhibitory crosstalk between cell death pathways.

The transmission spectrum of the exoplanet WASP-39b is obtained using observations from the Single-Object Slitless Spectroscopy mode of the Near Infrared Imager and Slitless Spectrograph instrument aboard the JWST.

CLOCK (CLK) is essential for the development and maintenance of circadian rhythms in Drosophila. Here, the authors show that Clk mRNA is regulated by miRNA bantam, and deletion of bantambinding site leads to stochastic CLK-driven transcription and development of the circadian neurons.

Papsdorf et al. show that mono-unsaturated fatty acids extend lifespan of C. elegans through induction of peroxisomes and lipid droplets in fat tissues and of a lipid signature predictive of decreased lipid oxidation.

The Nikon A1R HD25 confocal system with NIS-Elements AI software enables rapid, deep, quantitative imaging of living organs-on-chips.

Skyrmions in synthetic antiferromagnets are appealing for use in future memory and computing devices, combining small size and fast motion, but creating, stabilizing, and observing them remains a challenge. Here, Juge et al demonstrate the stabilization and current and light induced nucleation of skyrmions in a synthetic antiferromagnet, observing the magnetization texture in each layer using X-ray magnetic microscopy.

A method called MEDUSA was developed for identifying death regulatory genes in chemo-genetic profiling data, which enables characterization of a previously unappreciated mechanism of death induced by DNA damage in p53-deficient cells.

While machine learning platforms can improve the assessment of Hematoxylin & Eosin (H&E) stained-tumour tissue images, current models typically require manual cell-type annotations in training. Here, the authors develop VOLTA, a self-supervised machine learning framework to improve cell representation learning in H&E images based on the cells environment

Rab3GAP, a guanine nucleotide exchange factor for Rab18, regulates membrane trafficking and lipid droplet metabolism. The authors elucidated its molecular structure, mapped its potential substrate binding interface, and uncovered that disease-associated mutations likely impair Rab18 binding.

Comparing spatial omics data across samples remains elusive. Here, the authors develop a quantitative spatial framework, termed as colocatome analysis, by combining pairwise cell-cell colocalization, spatial permutation and normalization approaches for comparing features across conditions and studies.

The success of HER2-targeted cancer therapy is limited by treatment resistance. Here, the authors engineer an anti-HER2 biparatopic antibody with multiple mechanisms of action including induction of HER2 clustering to trigger complement dependent cytotoxicity, signal inhibition, antibody dependent cellular cytotoxicity and phagocytosis.

Factors that determine the cellular tropism of SARS-CoV-2 beyond the host cell receptor, ACE2, are poorly defined. Here, the authors show that tonic activation of the cGAS-STING sensing pathway potently blocks SARS-CoV-2 replication in a subset of ACE2-expressing airway-derived cells.

The ability to map the activity of synapses within a circuit will help in elucidating the neural basis of behaviour. Here, Macpherson et al. report new strategies to specifically label active synapses in Drosophila with multi-colour fluorescence tags.

A device architecture based on indium arsenide–aluminium heterostructures with a gate-defined superconducting nanowire allows single-shot interferometric measurement of fermion parity and demonstrates an assignment error probability of 1%.

Surface potential measurements of parallel WSe₂ and MoS₂ multi-layers with aligned and anti-aligned configurations of the polar interfaces were conducted showing evenly spaced, nearly decoupled potential steps, indicative of highly confined interfacial electric fields.

To improve the efficiency of photovoltaic devices while keeping the same spatial footprint, solar cells can be stacked on top of each other. Here, Essig et al. fabricate very efficient dual-junction and triple-junction solar cells by placing one or two III–V solar cells on top of a silicon solar cell.

Polyethylene terephthalate (PET) tape is widely used for lithium-ion batteries but its chemical stability has been largely overlooked. Reversible self-discharge is now shown to be virtually eliminated in LiFePO₄–graphite cells by replacing PET with polypropylene jellyroll tape.

How stable sensory and motor variables are represented in association brain areas such as retrosplenial cortex (RSC) during the performance of a cognitive task is not fully understood. Here authors show that mouse RSC can reliably store sensory information about the environmental context and trial outcome while exhibiting flexible coding of motor choice.

The behaviour of a superconductor can be altered by changing its symmetry properties. Coherently coupling two Josephson junctions breaks time-reversal and inversion symmetries, giving rise to a device with a controllable superconducting diode effect.

Device resilience under temperature cycling is critical for the practical implementation of perovskite photovoltaics. This Perspective highlights how stability evolves with thermal cycling, emphasizing the need for adequate protocols and a deeper understanding of the material and interface changes.

Two below-threshold surface code memories on superconducting processors markedly reduce logical error rates, achieving high efficiency and real-time decoding, indicating potential for practical large-scale fault-tolerant quantum algorithms.

Integrating cell-laden hydrogels effectively into the 3D printing process is a challenge in the creation of tissue engineering scaffolds. Here, the authors describe an additive manufacturing technique to combine polymer and cell-containing networks with 3D-printed mechanical supports.

Type 2 inflammation drives the formation of pathologic mucus in patients with asthma. Here, authors reveal a role for intelectin-1 in IL-13-induced mucus properties, and that an ITLN1 eQTL is associated with protection from the formation of mucus plugs in T2-high asthma.

Usnic acid is a lichen secondary metabolite and has a antitumor activity. Here the authors show that usnic acid rapidly blocks large ribosomal subunit formation. This hinders pre-rRNA processing and leads to depletion of key maturation factors such as Dbp10.

Redox signal transduction from the mitochondrial matrix to the cytosol is shown to be mediated through interaction between MIC60 and Miro, the disruption of which ameliorates oxidative stress in Drosophila.

Certifiably random bits can be generated using the 56-qubit Quantinuum H2-1 trapped-ion quantum computer accessed over the Internet.

While the impact of F-actin architecture on stress transmission is well studied, the role of architecture on stress generation remains unclear. Here authors use in vitro model and show that distinct organizations constrain myosin motion.

High-performance engineered myosins robustly change speed or direction in response to an optical signal. In living cells, these motors localize to the tips of protrusions when illuminated and deliver molecular cargos.

CRISPR–Cas9 screens in cultures of young and old neural stem cells (NSCs) and in vivo in old mice identify gene knockouts that can boost old NSC activation and neurogenesis, with Slc2a4, which encodes the glucose transporter GLUT4, showing particular efficacy.

Scheibner et al. demonstrate that, during gastrulation in the mouse, epithelial epiblast progenitors upregulate Foxa2 and form the definitive endoderm independently of a full EMT–MET cycle.

Stress transitions from horizontally forced compression to vertically forced extension during subduction initiation, according to seismic images of the Puysegur plate boundary, New Zealand.

A detailed whole-body model of the fruit fly, developed using a physics-based simulation and deep reinforcement learning, accurately replicates real fly behaviour.

Targeted protein degradation of cell-surface glycoproteins suppresses cancer in mice.

Precise control of electrons in two-dimensional materials has been limited by fabrication techniques for local gates that introduce disorder. Now, a technique allows patterning of sub-100 nm features and fabrication of very clean interfaces.

Here, Geoghegan, Evelyn et al. provide a lattice light-sheet microscopy based 4D imaging pipeline to quantitatively investigate Plasmodium spp. invasion and show that the nascent parasitophorous vacuole is predominantly formed from host’s erythrocyte membrane and undergoes continuous remodeling throughout invasion.

Dirac magnetoexcitons with non-trivial nanoscale electrodynamics are formed from the excitation of Landau levels in charge-neutral graphene. Here, the Dirac magnetoexciton dispersion is directly imaged up to 7 T via a magneto cryogenic near-field microscope.

By combining a CMOS-based integrated circuit with flexible and collapsible radiating structures, a scalable phased array architecture can be fabricated that has an areal mass density of only 0.1 g cm⁻².

The agrochemical mandipropamid (Mandi), which induces dimerization of a variant of the abscisic acid receptor, has been developed as a new chemical inducer of proximity for cellular and organismal applications.

Liquid crystalline elastomers (LCE) exhibit shape transformation when subjected to various stimuli, but the achievable thickness of LCE films is limited. Here the authors demonstrate arbitrarily thick LCE films that are continuous in composition and maintain the director orientation, prescribed into the material.