Nature Search

Modeling nicotinic neuromodulation from global functional and network levels to nAChR based mechanisms

Michael Graupner
Boris Gutkin
Reviews05 Jun 2009
Acta Pharmacologica Sinica

Volume: 30, P: 681-693
Spectroscopic confirmation of two luminous galaxies at a redshift of 14

JWST–NIRSpec spectroscopic confirmation of two luminous galaxies is presented, proving that luminous galaxies were already in place 300 million years after the Big Bang and are more common than what was expected before JWST.

Stefano Carniani
Kevin Hainline
Christopher N. A. Willmer
ResearchOpen Access29 Jul 2024
Nature

Volume: 633, P: 318-322
Restoring bone marrow niche function rejuvenates aged hematopoietic stem cells by reactivating the DNA Damage Response

Aging is associated with a loss of blood stem cell fitness in part due to defects in stem cell-supportive niches. Here, the authors demonstrate that restoring niche function by treatment with Netrin-1 is able to rejuvenate aged blood stem cells.

Pradeep Ramalingam
Michael C. Gutkin
Jason M. Butler
ResearchOpen Access10 Apr 2023
Nature Communications

Volume: 14, P: 1-20
Multilocus linkage of familial hyperkalaemia and hypertension, pseudohypoaldosteronism type II, to chromosomes 1q31-42 and 17p11-q21

Traci A. Mansfield
David B. Simon
Richard P. Lifton
Research01 Jun 1997
Nature Genetics

Volume: 16, P: 202-205
Author Correction: The bone marrow microenvironment at single-cell resolution

Anastasia N. Tikhonova
Igor Dolgalev
Iannis Aifantis
Amendments and Corrections12 Jul 2019
Nature

Volume: 572, P: E6
Endothelial-specific inhibition of NF-κB enhances functional haematopoiesis

The complex microenvironmental signalling pathways that govern haematopoietic stem cell (HSC) activity remain poorly defined. Here, the authors identify endothelial NF-κB signalling as regulating regenerative HSC function, accelerating haematopoietic recovery following myelosuppressive injury in mice.

Michael G. Poulos
Pradeep Ramalingam
Jason M. Butler
ResearchOpen Access21 Dec 2016
Nature Communications

Volume: 7, P: 1-15
Hereditary hypertension caused by chimaeric gene duplications and ectopic expression of aldosterone synthase

Richard P. Lifton
Robert G. Dluhy
Jean-Marc Lalouel
Research01 Sept 1992
Nature Genetics

Volume: 2, P: 66-74
Chronic activation of endothelial MAPK disrupts hematopoiesis via NFKB dependent inflammatory stress reversible by SCGF

Myelosuppressive injuries lead to chronic MAPK activation and impair blood reconstitution. Here, the authors show that chronic activation endothelial MAPK impairs hematopoietic stem cell (HSC) function through NFkB signaling, and that post-myelosuppressive HSC defects can be reversed by administration of Stem Cell Growth Factor SCGFa.

Pradeep Ramalingam
Michael G. Poulos
Jason M. Butler
ResearchOpen Access03 Feb 2020
Nature Communications

Volume: 11, P: 1-20
The bone marrow microenvironment at single-cell resolution

The transcriptional landscape of cell populations of the mouse bone marrow microenvironment, mapped at single-cell resolution, reveals cellular heterogeneity in this niche as well as substantial transcriptional remodelling under stress conditions.

Anastasia N. Tikhonova
Igor Dolgalev
Iannis Aifantis
Research10 Apr 2019
Nature

Volume: 569, P: 222-228
Sox17 drives functional engraftment of endothelium converted from non-vascular cells

Endothelial cells (ECs) are promising strategies to treat vasculopathies but little is known about the factors that sustain EC identity and govern functional integration into vasculature after transplantation. Here the authors show that Ets factors and Sox17 convert nonvascular cells to vascular cells with stable EC identity and function.

William Schachterle
Chaitanya R. Badwe
Shahin Rafii
ResearchOpen Access16 Jan 2017
Nature Communications

Volume: 8, P: 1-12
Mutations in kelch-like 3 and cullin 3 cause hypertension and electrolyte abnormalities

Exome sequencing identifies mutations in kelch-like 3 and cullin 3 as causes of a syndrome featuring high blood pressure and electrolyte abnormalities.

Lynn M. Boyden
Murim Choi
Richard P. Lifton
Research22 Jan 2012
Nature

Volume: 482, P: 98-102
Nicotine reverses hypofrontality in animal models of addiction and schizophrenia

In transgenic mouse models of neuropsychiatric disease, loss of nicotinic cholinergic signaling in cortical inhibitory interneurons causes neurocognitive behavioral deficits and reduced neuronal activity in prefrontal circuits. Chronic administration of nicotine can restore this cortical hypofrontality phenotype.

Fani Koukouli
Marie Rooy
Uwe Maskos
Research23 Jan 2017
Nature Medicine

Volume: 23, P: 347-354
Clinical and virologic characteristics of the first 12 patients with coronavirus disease 2019 (COVID-19) in the United States

Detailed clinical and virologic characteristics of the first 12 individuals with COVID-19 in the United States from the US Centers for Disease Control and Prevention.

Stephanie A. Kujawski
Karen K. Wong
Jing Zhang
Research23 Apr 2020
Nature Medicine

Volume: 26, P: 861-868

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