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A series of early-time, multiwavelength observations of an optical transient, AT2022cmc, indicate that it is a relativistic jet from a tidal disruption event originating from a supermassive black hole.

Observations of a luminous quasar from the high-resolution spectrometer Resolve aboard XRISM revealed highly inhomogeneous wind structure outflowing from a supermassive black hole, which probably consists of up to a million clumps.

Dysregulated R-loops can compromise genome stability, leading to pathological consequences. Li et al. demonstrate that R-loop-induced poly(ADP-ribose) polymerase 1 activation orchestrates exonuclease 3′–5′ ___domain-containing 2-mediated R-loop resolution, thereby safeguarding genomic integrity.

Application of a nanopore sequencing workflow for real-time analysis of brain tumors results in molecular classification within a 30-minute intraoperative window, followed by comprehensive profiling within 24 hours.

ZTF J1406+1222 is a wide hierarchical triple system that hosts a low-metallicity subdwarf star and a ‘black widow’ millisecond pulsar that has a highly varying optical flux and a 62-minute period.

Observations from the JWST of the second brightest GRB ever detected, GRB 230307A, indicate that it belongs to the class of long-duration GRBs resulting from compact object mergers, with the decay of lanthanides powering the longlasting optical and infrared emission.

Observations of optical flares from AT2022tsd (the ‘Tasmanian Devil’) show that they have durations on the timescale of minutes, occur over a period of months, are highly energetic, are probably nonthermal and have supernova luminosities.

In the Tumor Profiler proof-of-concept observational study, a multiomics approach for profiling tumors from patients with melanoma was feasible, returning data within 4 weeks and informing treatment recommendations in 75% of cases.

This work identifies a period structure in the radio emission of magnetars that can be observed in all classes of radio-emitting rotating neutron stars, regardless of their evolutionary history, their power source or their magnetic field strength.

Conditional cysteine restriction in mice causes substantial weight loss, exceeding that seen with essential amino acid restriction, by activating the integrated stress and oxidative stress responses, and by unexpectedly depleting coenzyme A, leading to metabolic inefficiency.

The tidal disruption event AT2019dsg is probably associated with a high-energy neutrino, suggesting that such events can contribute to the cosmic neutrino flux. The electromagnetic emission is explained in terms of a central engine, a photosphere and an extended synchrotron-emitting outflow.

Multiplexed error-robust fluorescence in situ hybridization (MERFISH) together with deep-learning-based nucleus segmentation enabled the construction of a highly detailed and informative spatially resolved single-cell atlas of human fetal cortical development.

The rotation rate of comet 41P/Tuttle–Giacobini–Kresák decreased rapidly between March and May 2017, owing to gas emission from the comet aligning to produce an anomalously strong torque.

Dynamic nanodomains in lead halide perovskites, dictated by A-site cations, crucially affect the optoelectronic properties by modulating electronic disorder and consequently enabling better solar cells and optoelectronic devices.

Harmful algal blooms (HABs) pose negative worldwide impacts that could be minimized through the development of a forecasting tool. Quantitative analysis of peptides produced by a coastal microbiome prior to a HAB reveals predictive biomarkers that can forecast bloom events over 24 hours in advance.

A luminous optical flash from GRB 210619B was captured rapidly by robotic telescopes and attributed to an extremely fast, narrow and magnetized jet shocked by propagating into the surrounding medium.

Phenotypic profiling by high-throughput imaging can aid in the screening of perturbations in cell models, but most studies often overlook cell-to-cell variation of responses within samples/populations. Here, the authors present SPACe, an easy-to-deploy, open-source platform for analysis of single-cell image-based morphological profiles produced by Cell Painting.

Observations of V404 Cygni, an X-ray transient containing a black hole of nine solar masses and a companion star, show that optical oscillations on timescales of 100 seconds to 2.5 hours can occur at mass-accretion rates at least ten times lower than previously thought, suggesting that the accretion rate is not the critical parameter for inducing inner-disk instabilities.

Radiation pressure on dusty gas is the main physical mechanism that regulates the distribution of the circumnuclear material that obscures many supermassive black holes.

Coordinating protein translation with energy supply is a significant challenge faced by cells. Here, the authors found that the protein quality control network may provide a link between the two.

Cell-surface receptors form the front line of plant immunity. Here, the authors show that the RLP co-receptors SOBIR1 and BAK1 directly phosphorylate each other, leading to activation of the immune receptor complex in which RLCKs are differentially required for production of reactive oxygen species that play a role in resistance against Phytophthora palmivora.

Two very-high-frequency quasi-periodic oscillations (at 2,132 Hz and 4,250 Hz) are detected within the initial hard spike of a magnetar giant flare originating from the galaxy NGC 253, and detailed temporal and spectral analyses are performed.

The JWST MIRI transmission spectrum of WASP-107b, a transiting planet with Neptune-like mass and Jupiter-like radius, shows observations of sulfur dioxide and silicate clouds but no methane in its atmosphere, providing evidence of disequilibrium chemistry and active photochemistry.

Quasi-elastic neutron scattering measurements show the existence of a body-centred cubic structure, similar to that of ice VII, where water molecules exhibit picosecond rotational dynamic and rapid orientational jumps characteristic of liquid water.

The spectral properties of a short gamma-ray burst indicate that, contrary to expectations, it arose from the collapse of a massive star rather than from a compact binary merger. This discovery also confirms that most collapsars do not produce ultra-relativistic jets.

Using the MeerKAT radio telescope, the authors have discovered a neutron star with an ultra-long spin period of 76 s. Though it resides in the neutron star graveyard, it emits radio waves and challenges our understanding of neutron star evolution.

A self-consistent model that bridges electrochemistry and solid-state physics is developed to fully describe the ion and electron distribution at solid electrode/electrolyte interfaces and applied to lower interfacial resistance in batteries.

A type Ia supernova shows the presence of helium-rich circumstellar material, as demonstrated by its spectral features, infrared emission and a radio counterpart, that probably originates from a single-degenerate system in which a white dwarf accretes material from a helium donor star.

A series of molecular fractals, specifically Sierpiński triangles, can be assembled on a Ag(111) surface from small, bent oligophenyls with a bromo group at each end. The self-assembly is driven by the formation of synergistic halogen and hydrogen bonds between the molecular building blocks, and defect-free structures with more than 100 individual components are observed.

Post-acute sequelae of SARS-CoV-2 (PASC) is still not well understood. Here the authors provide patient reported outcomes from 590 hospitalized COVID-19 patients and show association of PASC with higher respiratory SARS-CoV-2 load and circulating antibody titers, and in some an elevation in circulating fibroblast growth factor 21.

Mitophagy is an important quality control pathway. Here, the authors identify the mechanisms enabling the TBK1 adaptors NAP1 and SINTBAD to prevent hyperactivation of PINK1/Parkin mitophagy while promoting the pathway once set in motion.

Infrared brightening and luminosity observations from a young, solar-like star suggest a collision between two exoplanets producing a hot, highly extended post-impact remnant and transit of the debris causing the visible light eclipse of the host star.

Single-molecule FRET (smFRET) studies often struggle with large parameter spaces. Here, the authors introduce an automated smFRET platform for multiwell plate screening of biomolecular conformations and dynamics.

There is limited data on how SARS-CoV-2 antivirals compare regarding efficacy and blocking transmission. Here, treating dwarf hamsters and ferrets with either molnupiravir or paxlovid the authors find comparable efficacy against severe COVID-19-like disease and complete block of transmission by molnupiravir.

A radio-loud magnetar, XTE J1810–197, has been observed to precess shortly after an X-ray outburst. The precession decayed over the subsequent few months, which probably rules out freely precessing magnetars as the source of the fast radio bursts.