Nature Search

The GATE glycoprotein complex enhances human cytomegalovirus entry in endothelial cells

The gH-associated tropism and entry (GATE) complex consists of glycoprotein H, UL116 and UL141. This complex is abundant on human cytomegalovirus virions and enables entry into human endothelial cells.

Michael J. Norris
Lauren A. Henderson
Jeremy P. Kamil
Research30 Jun 2025
Nature Microbiology

Volume: 10, P: 1605-1616
Stephen Henry Schneider (1945–2010)

A voice of reason in climate-change science and policy.

Michael D. Mastrandrea
News & Views18 Aug 2010
Nature

Volume: 466, P: 933
Fine-mapping genomic loci refines bipolar disorder risk genes

This study used fine-mapping to analyze genetic regions associated with bipolar disorder, identifying specific risk genes and providing new insights into the biology of the condition that may guide future research and treatment approaches.

Maria Koromina
Ashvin Ravi
Niamh Mullins
ResearchOpen Access25 Jun 2025
Nature Neuroscience

Volume: 28, P: 1393-1403
Association between self-reported multimorbidity and longitudinal brain Aβ deposition in Alzheimer’s disease

Whether multimorbidity accelerates brain Aβ deposition in humans remains largely unknown. Here, the authors demonstrate that higher self-reported multimorbidity burden predicts increased brain Aβ accumulation rates in the ADNI cohort.

Xian-Le Bu
Wei Zhu
Kristin Fargher
ResearchOpen Access01 Jul 2025
Nature Communications

Volume: 16, P: 1-12
Characterising acute and chronic care needs: insights from the Global Burden of Disease Study 2019

Chronic care manages long-term, progressive conditions, while acute care handles short-term ones. Here, authors show chronic conditions account for most of the global health burden, with 68% of DALYs and 93% of YLDs attributed to chronic care needs.

Cecilia Anza-Ramirez
J. Jaime Miranda
Yves Miel H. Zuniga
ResearchOpen Access07 May 2025
Nature Communications

Volume: 16, P: 1-36
Immune correlates of anti-BCMA CAR-T products idecabtagene vicleucel and ciltacabtagene autoleucel in a real-world cohort of patients with multiple myeloma

Two BCMA-targeted CAR T products, idecabtagene vicleucel (ide-cel) and ciltacabtagene autoleucel (cilta-cel), have been approved for the treatment of multiple myeloma (MM). Here the authors report distinct expansion, phenotype, function, and toxicity of cilta-cel vs. ide-cel CAR T cells in a realworld cohort of patients with MM.

Djordje Atanackovic
Tim Luetkens
Mehmet H. Kocoglu
ResearchOpen Access04 Jul 2025
Nature Communications

Volume: 16, P: 1-12
Structure of lymphostatin, a large multi-functional virulence factor of pathogenic Escherichia coli

Lymphostatin is a large protein required for Escherichia coli virulence. Here, Griessmann et al. use electron cryo-microscopy to describe the structure of lymphostatin determined at different pH values, showing three conformations, six distinct domains, and long inter-___domain linkers that occlude the catalytic sites of the N-terminal glycosyltransferase and protease domains.

Matthias Griessmann
Tim Rasmussen
Bettina Böttcher
ResearchOpen Access25 Jun 2025
Nature Communications

Volume: 16, P: 1-14
Transferability of European-derived Alzheimer’s disease polygenic risk scores across multiancestry populations

Polygenic risk scores for Alzheimer’s disease derived from individuals of European ancestry can show improved performance in multiancestry settings after incorporating genome-wide association summary statistics from diverse populations.

Aude Nicolas
Richard Sherva
Jean-Charles Lambert
ResearchOpen Access18 Jun 2025
Nature Genetics

P: 1-13
Resolving the phase of Fano resonance wave packets with photoelectron frequency-resolved optical gating

The researchers demonstrate direct measurement and complete characterization of structured electronic wave packets created within a prototypical Fano resonance. The method may be broadly applicable to the study of ultrafast processes, especially electronic ones, in complex systems, as well as coherent control of such systems on their fundamental timescales.

Pengju Zhang
Hao Liang
Hans Jakob Wörner
ResearchOpen Access01 Jul 2025
Nature Photonics

P: 1-7
Pheromones in the Communication of Sexual Status in Primates

R. P. MICHAEL
E. B. KEVERNE
Research25 May 1968
Nature

Volume: 218, P: 746-749
The 40S ribosomal subunit recycling complex modulates mitochondrial dynamics and endoplasmic reticulum - mitochondria tethering at mitochondrial fission/fusion hotspots

Coordinating protein translation with energy supply is a significant challenge faced by cells. Here, the authors found that the protein quality control network may provide a link between the two.

Foozhan Tahmasebinia
Yinglu Tang
Zhihao Wu
ResearchOpen Access25 Jan 2025
Nature Communications

Volume: 16, P: 1-24
Behaviour modification by in vitro mutagenesis of a variable region within the period gene of Drosophila

Qiang Yu
Hildur V. Colot
Michael Rosbash
Research01 Apr 1987
Nature

Volume: 326, P: 765-769
An international Delphi consensus for reporting of setting in psychedelic clinical trials

A large international panel of experts reach consensus on a new standard for reporting settings in psychedelic trials, identifying 30 key non-pharmacological factors to strengthen the rigor of psychedelic research.

Chloé Pronovost-Morgan
Kyle T. Greenway
Keith Williams
ResearchOpen Access03 Jun 2025
Nature Medicine

P: 1-10
Parenteral Copper in Copper-Deficiency Diseases of Animals

A. ASHFORD
S. E. MICHAEL
Research01 Sept 1962
Nature

Volume: 195, P: 867-869
Rapid human-induced evolution of insect–host associations

Michael C. Singer
Chris D. Thomas
Camille Parmesan
Research16 Dec 1993
Nature

Volume: 366, P: 681-683
Protein-responsive gut hormone tachykinin directs food choice and impacts lifespan

The gut hormone tachykinin (Tk) is found to be regulated by protein intake in flies and mice. In flies, Tk is shown to impact food choices, sleep and lifespan.

Nadja Ahrentløv
Olga Kubrak
Kim Rewitz
ResearchOpen Access14 Apr 2025
Nature Metabolism

Volume: 7, P: 1223-1245
Genomic, transcriptomic, and immunogenomic landscape of over 1300 sarcomas of diverse histology subtypes

Sarcoma is a highly heterogeneous disease, which can be caused by a large variety of mutations. Here, the authors utilise multi-omics to characterise a cohort of 1,340 sarcoma tissue specimens to identify key somatic mutations and identify immune subtypes.

Alex Soupir
Oscar E. Ospina
Andrew S. Brohl
ResearchOpen Access06 May 2025
Nature Communications

Volume: 16, P: 1-11
Dermatologist-like explainable AI enhances melanoma diagnosis accuracy: eye-tracking study

Artificial intelligence (AI) system is known to improve dermatologists’ diagnostic accuracy for melanoma. This group applies the eye-tracking technology on dermatologists when diagnosing dermoscopic images of melanomas and reports improved balanced diagnostic accuracy when using an X(explainable) AI system comparing to the standard one.

Tirtha Chanda
Sarah Haggenmueller
Titus J. Brinker
ResearchOpen Access21 May 2025
Nature Communications

Volume: 16, P: 1-10
RNF20 links the DNA damage response and metabolic rewiring in lung cancer through HIF1α

Loss of RNF20 is associated with aggressive cancer phenotypes. Here the authors show that Rnf20 haploinsufficiency leads to the formation of lung tumours due to defective DNA repair and HIF1α-mediated metabolic rewiring.

Hao Liu
Yongqin Tang
Gergana Dobreva
ResearchOpen Access28 May 2025
Nature Communications

Volume: 16, P: 1-22
The Normal Fetal Heart Rate Study: Analysis Plan

Martin Daumer PhD
Michael Scholz
K T M Schneider MD
ResearchOpen Access12 Nov 2007
Nature Precedings

P: 1
The Normal Fetal Heart Rate Study: Analysis Plan

Martin Daumer PhD
Michael Scholz
K T M Schneider MD
ResearchOpen Access17 Sept 2007
Nature Precedings

P: 1
Thyroid cancer incidence

Elaine Ron
Jay Lubin
Arthur B. Schneider
Research12 Nov 1992
Nature

Volume: 360, P: 113
Genome-wide association study of long COVID

A genome-wide study by the Long COVID Host Genetics Initiative identifies an association between the FOXP4 locus and long COVID, implicating altered lung function in its pathophysiology.

Vilma Lammi
Tomoko Nakanishi
Hanna M. Ollila
ResearchOpen Access21 May 2025
Nature Genetics

Volume: 57, P: 1402-1417
Anti-Ebola virus mAb 3A6 protects highly viremic animals from fatal outcome via binding GP_(1,2) in a position elevated from the virion membrane

Here, combining X-ray crystallography, cryo-electron tomography and animal studies, the authors show that the monoclonal antibody against Ebola virus glycoprotein (GP1,2) 3A6 exerts protection via binds to a conformation of GP1,2 that is lifted from the virion membrane, providing insights into the mechanism of action with implications for the design of anti-Ebola therapeutics.

Kathryn M. Hastie
Zhe Li Salie
Erica Ollmann Saphire
ResearchOpen Access03 Feb 2025
Nature Communications

Volume: 16, P: 1-12
Prevalence and biological impact of clinically relevant gene fusions in head and neck cancers

Emily L. Hoskins
Raven Vella
Sameek Roychowdhury
ResearchOpen Access03 Jul 2025
npj Precision Oncology

Volume: 9, P: 1-13
Prediction of Functional Sites in SCOP Domains using Dynamics Perturbation Analysis

Judith Cohn
Dengming Ming
Michael Wall
ResearchOpen Access21 Aug 2008
Nature Precedings

P: 1
Plasma extracellular vesicle tau and TDP-43 as diagnostic biomarkers in FTD and ALS

Plasma extracellular vesicles contain quantifiable amounts of TDP-43 and full-length tau, allowing the accurate assessment of pathology in frontotemporal dementia, frontotemporal dementia spectrum disorders and amyotrophic lateral sclerosis.

Madhurima Chatterjee
Selcuk Özdemir
Anja Schneider
ResearchOpen Access18 Jun 2024
Nature Medicine

Volume: 30, P: 1771-1783
Author Correction: GWAS of multiple neuropathology endophenotypes identifies new risk loci and provides insights into the genetic risk of dementia

Lincoln M. P. Shade
Yuriko Katsumata
David W. Fardo
Amendments and CorrectionsOpen Access17 Jun 2025
Nature Genetics

P: 1
Publisher Correction: GWAS of multiple neuropathology endophenotypes identifies new risk loci and provides insights into the genetic risk of dementia

Lincoln M. P. Shade
Yuriko Katsumata
David W. Fardo
Amendments and CorrectionsOpen Access17 Jun 2025
Nature Genetics

P: 1
Publisher Correction: Multi-orbital charge transfer at highly oriented organic/metal interfaces

Giovanni Zamborlini
Daniel Lüftner
Claus Michael Schneider
Amendments and CorrectionsOpen Access30 Nov 2017
Nature Communications

Volume: 8, P: 1
Genomics yields biological and phenotypic insights into bipolar disorder

Using multi-ancestry genome-wide association study and fine-mapping, 298 loci and 36 credible genes are identified in the aetiology of bipolar disorder.

Kevin S. O’Connell
Maria Koromina
Dan Siskind
Research22 Jan 2025
Nature

Volume: 639, P: 968-975
Acid-dependent ligand dissociation and recycling of LDL receptor mediated by growth factor homology region

C. Geoffrey Davis
Joseph L. Goldstein
Michael S. Brown
Research01 Apr 1987
Nature

Volume: 326, P: 760-765
Proteotoxic stress is a driver of the loser status and cell competition

Baumgartner et al. identify proteotoxic stress as the underlying cause of the loser status in a cell competition model caused by reduced autophagic, proteasomal flux and accumulation of protein aggregates.

Michael E. Baumgartner
Michael P. Dinan
Eugenia Piddini
Research25 Jan 2021
Nature Cell Biology

Volume: 23, P: 136-146
CYP5122A1 encodes an essential sterol C4-methyl oxidase in Leishmania donovani and determines the antileishmanial activity of antifungal azoles

CYP5122A1 is a sterol C4-methyl oxidase that catalyzes the sequential oxidation of lanosterol, is essential for both Leishmania donovani promastigotes in culture and intracellular amastigotes in infected mice, and provides a new target for antileishmanial drug discovery.

Yiru Jin
Somrita Basu
Michael Zhuo Wang
ResearchOpen Access31 Oct 2024
Nature Communications

Volume: 15, P: 1-19
Regulation of a protein synthesis initiation factor by adenovirus virus-associated RNA_I

Patricia A. Reichel
William C. Merrick
Michael B. Mathews
Research17 Jan 1985
Nature

Volume: 313, P: 196-200
LGR signaling mediates muscle-adipose tissue crosstalk and protects against diet-induced insulin resistance

Obesity induces insulin resistance and impairs insulin signaling, causing diabetes. Here, the authors show that BMP and LGR signaling mediate communication between muscle, neuronal, and adipose tissues to enhance insulin signaling, identifying LGR as key in protecting against insulin resistance.

Olga Kubrak
Anne F. Jørgensen
Kim Rewitz
ResearchOpen Access20 Jul 2024
Nature Communications

Volume: 15, P: 1-22
HBsAg-vectored DNA vaccines elicit concomitant protective responses to multiple CTL epitopes relevant in human disease.

Dekun Chen
Allan Gould
Robert Tindle
ResearchOpen Access27 May 2008
Nature Precedings

P: 1
Protein-RNA molecular recognition

Michael Ibba
Dieter Söll
Research20 Jun 1996
Nature

Volume: 381, P: 656
The extended sodium nebula of Jupiter

Michael Mendillo
Jeffrey Baumgardner
W. Jeffrey Hughes
Research22 Nov 1990
Nature

Volume: 348, P: 312-314
Mapping the human genetic architecture of COVID-19

A global network of researchers was formed to investigate the role of human genetics in SARS-CoV-2 infection and COVID-19 severity; this paper reports 13 genome-wide significant loci and potentially actionable mechanisms in response to infection.

Mari E. K. Niemi
Juha Karjalainen
Chloe Donohue
ResearchOpen Access08 Jul 2021
Nature

Volume: 600, P: 472-477
Unifying the analysis of bottom-up proteomics data with CHIMERYS

CHIMERYS is a spectrum-centric and data acquisition method-agnostic algorithm for the analysis of MS2 spectra. It is capable of deconvoluting any MS2 spectrum, regardless of whether it was acquired by DDA, DIA or PRM, thus unifying the analysis of bottom-up proteomics data.

Martin Frejno
Michelle T. Berger
Mathias Wilhelm
ResearchOpen Access22 Apr 2025
Nature Methods

Volume: 22, P: 1017-1027
Navigating parental hesitancy in public health: the case for RSV immunization in newborns

Michael K. Baumgartner
Gregor Hanslik
Fabian B. Fahlbusch
ResearchOpen Access11 Apr 2025
Journal of Perinatology

P: 1-5
Parameter Sensitivity as a Criterion for Evaluating and Comparing the Performance of Biochemical Systems

MICHAEL A. SAVAGEAU
Research19 Feb 1971
Nature

Volume: 229, P: 542-544
Reflect: Augmented Browsing for the Life Scientist

Evangelos Pafilis
Seán O'Donoghue
Reinhard Schneider
ResearchOpen Access04 May 2009
Nature Precedings

P: 1
New insights into the genetic etiology of Alzheimer’s disease and related dementias

Meta-analysis of genome-wide association studies on Alzheimer’s disease and related dementias identifies new loci and enables generation of a new genetic risk score associated with the risk of future Alzheimer’s disease and dementia.

Céline Bellenguez
Fahri Küçükali
Jean-Charles Lambert
ResearchOpen Access04 Apr 2022
Nature Genetics

Volume: 54, P: 412-436
Lethal trap created by adaptive evolutionary response to an exotic resource

Local extinction of the butterfly Euphydryas editha occurred after the population was caught in an eco-evolutionary trap set when the insects evolved unanimous preference for an exotic host, Plantago lanceolata, and sprung when that host became embedded in grasses after humans removed cattle.

Michael C. Singer
Camille Parmesan
Research09 May 2018
Nature

Volume: 557, P: 238-241
Setting the record straight (again)

Michael E. Mann
Paul R. Ehrlich
Stefan Rahmstorf
Correspondence20 Oct 2010
Nature

Volume: 467, P: 920
Evolution of temperature preference in flies of the genus Drosophila

A study using flies of the genus Drosophila adapted to life in diverse thermal environments shows how evolution has shaped temperature preference by acting on both molecular heat receptors and thermosensory circuits in the flies.

Matthew Capek
Oscar M. Arenas
Marco Gallio
Research05 Mar 2025
Nature

Volume: 641, P: 447-455
Sliding-layer conformational change limited by the quaternary structure of plant RuBisCO

Michael S. Chapman
Se Won Suh
David Eisenberg
Research24 Sept 1987
Nature

Volume: 329, P: 354-356
Activation of BPV-1 replication in vitro by the transcription factor E2

Liu Yang
Rong Li
Michael R. Botchan
Research17 Oct 1991
Nature

Volume: 353, P: 628-632

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