Nature Search

Integrative proteomic analyses across common cardiac diseases yield mechanistic insights and enhanced prediction

Schuermans et al. identify a causal relationship between the circulating proteins spondin-1 and atrial fibrillation and SPINT1 and coronary artery disease and show that adding proteomic data improves clinical risk factor-based cardiovascular risk prediction.

Art Schuermans
Ashley B. Pournamdari
Pradeep Natarajan
ResearchOpen Access21 Nov 2024
Nature Cardiovascular Research

Volume: 3, P: 1516-1530
Applying a genetic risk score model to enhance prediction of future multiple sclerosis diagnosis at first presentation with optic neuritis

People who experience optic neuritis, a cause of potentially serious sudden vision loss, have up to a 50% chance of ultimately being diagnosed with multiple sclerosis. Here, the authors find that genetic information combined with age and sex helps predict risk of future diagnosis of multiple sclerosis.

Pavel Loginovic
Feiyi Wang
Tasanee Braithwaite
ResearchOpen Access28 Feb 2024
Nature Communications

Volume: 15, P: 1-13
Reconstitution by MHC-restricted peptides of HLA-A2 heavy chain with β2-microglobulin, in vitro

Michael L. Silver
Kenneth C. Parker
Don C. Wiley
Research18 Apr 1991
Nature

Volume: 350, P: 619-622
Proteomic analysis of cardiorespiratory fitness for prediction of mortality and multisystem disease risks

A proteomic risk score for cardiorespiratory fitness, comprising as few as 21 proteins, is dynamic with exercise training and helps predict the risk of mortality and a range of cardiovascular, metabolic and neurological conditions.

Andrew S. Perry
Eric Farber-Eger
Ravi V. Shah
ResearchOpen Access04 Jun 2024
Nature Medicine

Volume: 30, P: 1711-1721
Transancestral GWAS of alcohol dependence reveals common genetic underpinnings with psychiatric disorders

Different functional variants in ADH1B (and elsewhere) in Europeans and Africans strongly affect risk for alcohol dependence. Dependence only partly genetically correlates with consumption, with strong correlations to other psychiatric disorders.

Raymond K. Walters
Renato Polimanti
Arpana Agrawal
Research26 Nov 2018
Nature Neuroscience

Volume: 21, P: 1656-1669
Haemopoietic colony stimulating factors promote cell survival by suppressing apoptosis

Gwyn T. Williams
Christopher A. Smith
Dale R. Taylor
Research04 Jan 1990
Nature

Volume: 343, P: 76-79
Cytotoxic T cells specific for the circumsporozoite protein of Plasmodium falciparum

Sanjai Kumar
Louis H. Miller
Michael F. Good
Research21 Jul 1988
Nature

Volume: 334, P: 258-260
Proteomic risk scores for predicting common diseases using linear and neural network models in the UK biobank

Alexander Smith
Paul Elliott
Ioanna Tzoulaki
ResearchOpen Access01 Jul 2025
Scientific Reports

Volume: 15, P: 1-11
A role for the ubiquitin-dependent proteolytic pathway in MHC class l-restricted antigen presentation

Michael T. Michalek
Ethan P. Grant
Kenneth L. Rock
Research10 Jun 1993
Nature

Volume: 363, P: 552-554
A survey of pathogenic involvement in non-communicable human diseases

Lape et al. use electronic health records and a discovery-replication cohort study design to investigate links between common pathogens and non-communicable diseases. Evidence is found for over 200 associations, such as a role for human cytomegalovirus in ulcerative colitis.

Michael Lape
Daniel Schnell
Matthew T. Weirauch
ResearchOpen Access20 Jun 2025
Communications Medicine

Volume: 5, P: 1-15
Identifying reliable traits across laboratory mouse exploration arenas: A meta-analysis

Michael Galsworthy
Rime Madani
Hans-Peter Lipp
ResearchOpen Access12 Mar 2012
Nature Precedings

P: 1
Deactivation of macrophages by transforming growth factor-β

Shohko Tsunawaki
Michael Sporn
Carl Nathan
Research21 Jul 1988
Nature

Volume: 334, P: 260-262
Identification of host–pathogen-disease relationships using a scalable multiplex serology platform in UK Biobank

Here, the authors design a multiplex serology platform to quantitatively measure antibodies against 20 infectious agents in UK Biobank participants and confirm associations of antibody responses with sociodemographic characteristics, HLA genetic variants, and disease outcomes.

Alexander J. Mentzer
Nicole Brenner
Tim Waterboer
ResearchOpen Access05 Apr 2022
Nature Communications

Volume: 13, P: 1-12
Erratum: Myosin head movements are synchronous with the elementary force-generating process in muscle

Malcolm Irving
Vincenzo Lombardi
Michael A. Ferenczi
Amendments and Corrections25 Jun 1992
Nature

Volume: 357, P: 704
Ham-2 corrects the class I antigen-processing defect in RMA-S cells

Michelle Attaya
Stephen Jameson
John J. Monaco
Research13 Feb 1992
Nature

Volume: 355, P: 647-649
Spring phytoplankton blooms in the absence of vertical water column stratification

David W. Townsend
Maureen D. Keller
Steven G. Ackleson
Research05 Nov 1992
Nature

Volume: 360, P: 59-62
Receptor binding redefined by a structural switch in a mutant human insulin

Qing Xin Hua
Steven E. Shoelson
Michael A. Weiss
Research21 Nov 1991
Nature

Volume: 354, P: 238-241
Low depression frequency is associated with decreased risk of cardiometabolic disease

Honigberg and colleagues analyzed the frequency of depressed mood in conjunction with polygenic risk scores for coronary artery disease (CAD), type 2 diabetes (T2D) and atrial fibrillation in the UK Biobank and showed that depressed mood was independently associated with a lower risk of CAD and T2D across the cardiometabolic polygenic risk spectrum.

Michael C. Honigberg
Yixuan Ye
Pradeep Natarajan
Research14 Feb 2022
Nature Cardiovascular Research

Volume: 1, P: 125-131
Multi-ancestry genome-wide association study of cannabis use disorder yields insight into disease biology and public health implications

Multi-ancestry genome-wide association meta-analyses identify risk loci for cannabis use disorder. Genomic structural equation modeling and genetic correlation analyses show overlap with several other traits, including impulsivity and psychopathology.

Daniel F. Levey
Marco Galimberti
Joel Gelernter
ResearchOpen Access20 Nov 2023
Nature Genetics

Volume: 55, P: 2094-2103
Atomic structure of a human MHC molecule presenting an influenza virus peptide

Michael L. Silver
Hwai-Chen Guo
Don C. Wiley
Research26 Nov 1992
Nature

Volume: 360, P: 367-369
Multi-ancestry meta-analysis of tobacco use disorder identifies 461 potential risk genes and reveals associations with multiple health outcomes

In 653,790 individuals, this multi-ancestral meta-analysis of tobacco use disorder finds 461 potential risk genes and hundreds of associations with health outcomes, showcasing the utility of electronic health records for genetic research.

Sylvanus Toikumo
Mariela V. Jennings
Sandra Sanchez-Roige
Research17 Apr 2024
Nature Human Behaviour

Volume: 8, P: 1177-1193
Co-localization of molecules involved in antigen processing and presentation in an early endocytic compartment

Lynne E. Guagliardi
Bruce Koppelman
Frances M. Brodsky
Research11 Jan 1990
Nature

Volume: 343, P: 133-139
Class discrimination in the world of immunology

Michael J. Bevan
News & Views15 Jan 1987
Nature

Volume: 325, P: 192-193
Prodromal Parkinson’s disease and subsequent risk of Parkinson’s disease and mortality

Xiao Chen
Yaqi Li
Xiang Gao
ResearchOpen Access09 Jan 2025
npj Parkinson's Disease

Volume: 11, P: 1-8
A phenome-wide association and Mendelian Randomisation study of polygenic risk for depression in UK Biobank

Depression is correlated with many brain-related traits. Here, Shen et al. perform phenome-wide association studies of a depression polygenic risk score (PRS) and find associations with 51 behavioural and 26 neuroimaging traits which are further followed up on using Mendelian randomization and mediation analyses.

Xueyi Shen
David M. Howard
Andrew M. McIntosh
ResearchOpen Access08 May 2020
Nature Communications

Volume: 11, P: 1-16
Genetic determinants of daytime napping and effects on cardiometabolic health

The genetic basis of daytime napping and the directional effect of daytime napping on cardiometabolic health are unknown. Here, the authors perform a genome-wide association study on self-reported daytime napping in the UK Biobank and Mendelian randomization to explore causal associations.

Hassan S. Dashti
Iyas Daghlas
Richa Saxena
ResearchOpen Access10 Feb 2021
Nature Communications

Volume: 12, P: 1-15
What is supersymmetry?

Michael Atiyah
Books & Arts04 Dec 1986
Nature

Volume: 324, P: 419
Murine psoriasis-like disorder induced by naive CD4⁺ T cells

Michael P. SchÖn
Michael Detmar
Christina M. Parker
Research01 Feb 1997
Nature Medicine

Volume: 3, P: 183-188
Genome-wide association study identifies genetic loci for self-reported habitual sleep duration supported by accelerometer-derived estimates

Sleep is essential for homeostasis and insufficient or excessive sleep are associated with adverse outcomes. Here, the authors perform GWAS for self-reported habitual sleep duration in adults, supported by accelerometer-derived measures, and identify genetic correlation with psychiatric and metabolic traits

Hassan S. Dashti
Samuel E. Jones
Richa Saxena
ResearchOpen Access07 Mar 2019
Nature Communications

Volume: 10, P: 1-12
One-quarter of freshwater fauna threatened with extinction

A global multi-taxon extinction risk assessment of freshwater fauna for The IUCN Red List of Threatened Species finds one-quarter of species to be at high risk of extinction.

Catherine A. Sayer
Eresha Fernando
William R. T. Darwall
ResearchOpen Access08 Jan 2025
Nature

Volume: 638, P: 138-145
A silicon sensor for SO₂

Michael T. Kelly
Jonathan K. M. Chun
Andrew B. Bocarsly
Research18 Jul 1996
Nature

Volume: 382, P: 214-215
Personalised lung cancer risk stratification and lung cancer screening: do general practice electronic medical records have a role?

Bhautesh Dinesh Jani
Michael K. Sullivan
Frank M. Sullivan
ResearchOpen Access25 Oct 2023
British Journal of Cancer

Volume: 129, P: 1968-1977
Meiotic initiation by the mos protein in Xenopus

Nelson Yew
Michael L. Mellini
George F. Vande Woude
Research13 Feb 1992
Nature

Volume: 355, P: 649-652
Positive selection of T-lymphocytes induced by intrathymic injection of a thymic epithelial cell line

Stanislav Vukmanović
Andres G. Grandea III
Michael J. Bevan
Research22 Oct 1992
Nature

Volume: 359, P: 729-732
Enterotoxin residues determining T-cell receptor Vβ binding specificity

Michael J. Irwin
Keith R. Hudson
Nicholas R. J. Gascoigne
Research29 Oct 1992
Nature

Volume: 359, P: 841-843
Population genomics of domestic and wild yeasts

David Carter
Gianni Liti
Edward Louis
ResearchOpen Access20 Jun 2008
Nature Precedings

P: 1
Genome-wide association analyses of risk tolerance and risky behaviors in over 1 million individuals identify hundreds of loci and shared genetic influences

A genetic study identifies hundreds of loci associated with risk tolerance and risky behaviors, finds evidence of substantial shared genetic influences across these phenotypes, and implicates genes involved in neurotransmission.

Richard Karlsson Linnér
Pietro Biroli
Jonathan P. Beauchamp
Research14 Jan 2019
Nature Genetics

Volume: 51, P: 245-257
Genetic modifiers of rare variants in monogenic developmental disorder loci

Analysis of genetic modifiers of 599 developmental disorder genes in the UK Biobank found that rare variant burden within this set, as well as the common polygenic background, can alter the expressivity of cognitive and socioeconomic traits in an additive manner.

Rebecca Kingdom
Robin N. Beaumont
Caroline F. Wright
ResearchOpen Access18 Apr 2024
Nature Genetics

Volume: 56, P: 861-868
The cell surface receptors for interleukin-1α and interleukin-1β are identical

Steven K. Dower
Shirley R. Kronheim
David L. Urdal
Research20 Nov 1986
Nature

Volume: 324, P: 266-268
TP53-mediated clonal hematopoiesis confers increased risk for incident atherosclerotic disease

Zekavat, Matesanz, Viana-Huete et al. show an increased risk of peripheral artery disease and atherosclerosis in different vascular beds in patients with clonal hematopoiesis of indeterminate potential (CHIP) caused by mutations in DNA damage repair genes, such as TP53. Validations in a mouse model support the causal contribution of TP53-mutant CHIP to atherosclerosis.

Seyedeh M. Zekavat
Vanesa Viana-Huete
Derek Klarin
Research16 Jan 2023
Nature Cardiovascular Research

Volume: 2, P: 144-158
Publisher Correction: The molecular reach of antibodies crucially underpins their viral neutralisation capacity

Anna Huhn
Daniel Nissley
Omer Dushek
Amendments and CorrectionsOpen Access20 Mar 2025
Nature Communications

Volume: 16, P: 1
Effects of increased body mass index on employment status: a Mendelian randomisation study

Desmond D. Campbell
Michael Green
Srinivasa Vittal Katikireddi
ResearchOpen Access22 Jun 2021
International Journal of Obesity

Volume: 45, P: 1790-1801
Molecular analysis of the association of HLA-B53 and resistance to severe malaria

Adrian V. S. Hill
John Elvin
Hilton C. Whittle
Reviews03 Dec 1992
Nature

Volume: 360, P: 434-439
Correlations in sleeping patterns and circadian preference between spouses

Mendelian randomization analysis leveraging data from the UK Biobank and 23andMe, Inc., suggests that an individual’s sleep habits may impact those of their partner.

Rebecca C. Richmond
Laurence J. Howe
Céline Vetter
ResearchOpen Access13 Nov 2023
Communications Biology

Volume: 6, P: 1-14
Phenotype integration improves power and preserves specificity in biobank-based genetic studies of major depressive disorder

Phenotype imputation increases the effective sample size of major depressive disorder cases in UK Biobank, enhancing study power and polygenic risk score (PRS) accuracy. A new pleiotropy metric enables assessment of PRS specificity and comparison among different PRS models.

Andrew Dahl
Michael Thompson
Na Cai
ResearchOpen Access20 Nov 2023
Nature Genetics

Volume: 55, P: 2082-2093
Risk of hematological malignancies from CT radiation exposure in children, adolescents and young adults

Analysis of a European cohort estimated that 1–2 per 10,000 children, adolescents and young adults are expected to develop a hematological malignancy within 12 years following computed tomography examination.

Magda Bosch de Basea
Isabelle Thierry-Chef
Elisabeth Cardis
ResearchOpen Access09 Nov 2023
Nature Medicine

Volume: 29, P: 3111-3119
The molecular reach of antibodies crucially underpins their viral neutralisation capacity

Researchers developed an accurate model to analyse bivalent antibody binding. By analysing many SARS-CoV-2-specific antibodies, they found that their molecular reach can predict their neutralisation potency.

Anna Huhn
Daniel Nissley
Omer Dushek
ResearchOpen Access02 Jan 2025
Nature Communications

Volume: 16, P: 1-18
Menopause-induced 17β-estradiol and progesterone loss increases senescence markers, matrix disassembly and degeneration in mouse cartilage

Knee osteoarthritis has a sex-specific phenotype with post-menopausal persons experiencing the highest incidence. Here the authors investigate the underlying mechanisms in a mouse model of menopause and find that the loss of 17β-estradiol and progesterone enhanced susceptibility to senescence, extracellular matrix disassembly and cartilage degradation.

Gabrielle Gilmer
Hirotaka Iijima
Fabrisia Ambrosio
Research16 Jan 2025
Nature Aging

Volume: 5, P: 65-86
Early suppression of SIV replication by CD8⁺ nef-specific cytotoxic T cells in vaccinated macaques

Awen Gallimore
Martin Cranage
Frances Gotch
Research01 Nov 1995
Nature Medicine

Volume: 1, P: 1167-1173
Lytic growth of Kaposi's sarcoma–associated herpesvirus (human herpesvirus 8) in culture

Rolf Renne
Weidong Zhong
Don Ganem
Research01 Mar 1996
Nature Medicine

Volume: 2, P: 342-346

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