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Genome-wide study for circulating metabolites identifies 62 loci and reveals novel systemic effects of LPA

Circulating metabolites reflect human health and disease. Here, Kettunen et al. perform a genome-wide association study on 123 circulating metabolic traits and identify novel genetic loci influencing systemic metabolism. They also link new molecular pathways with a known cardiovascular risk factor Lp(a).

Johannes Kettunen
Ayşe Demirkan
Mika Ala-Korpela
ResearchOpen Access23 Mar 2016
Nature Communications

Volume: 7, P: 1-9
Atlas of plasma NMR biomarkers for health and disease in 118,461 individuals from the UK Biobank

The authors report a systematic analyses of blood biomarkers for metabolism against the whole spectrum of diseases in 100,000 individuals and reveals a prominent role of numerous metabolic biomarkers as risk markers beyond heart disease and diabetes.

Heli Julkunen
Anna Cichońska
Peter Würtz
ResearchOpen Access03 Feb 2023
Nature Communications

Volume: 14, P: 1-15
Metabolomic and genomic prediction of common diseases in 700,217 participants in three national biobanks

Identifying individuals at high risk for chronic diseases can improve prevention. Here, the authors show that blood metabolomics scores effectively stratify disease risk and compare favorably to genetic and clinical scores in population biobanks.

Jeffrey C. Barrett
Tõnu Esko
Peter Würtz
ResearchOpen Access21 Nov 2024
Nature Communications

Volume: 15, P: 1-14

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