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The authors report a study increasing hydrogen peroxide electrosynthesis kinetics over a Ni(OH)₂/CNT material. They show that the catalyst enhances H₂O dissociation and proton transfer in neutral media.

The function and regulatory mechanism of mRNA acetylation modification in cancer progression remains largely unknown. Here the authors identify that targeting tumor N4-acetylcytidine (ac4C) RNA acetyltransferase NAT10 improves anti-tumor response via MYC/CDK2/DNMT1/dsRNA/type I IFN pathway, and show the synergic anti-tumor effect of NAT10 inhibition with aPD-1.

The blood ApoM-S1P complex regulates vascular functions, but its role in neurogenic niches remains unclear. Here, the authors show that the blood ApoM-S1P complex preserves V-SVZ homeostasis and protects against early features of Alzheimer’s disease.

An integrated smart capsule that encapsulates an array of electrochemical sensors can provide real-time, continuous and multiplexed monitoring of the gastrointestinal tract.

Safe electrolytes for wide temperature applications of lithium metal batteries are highly demanded. Here, authors develop an ether-based electrolyte with 1,3,5-trioxane additive which renders thermoresponsivity, enabling lithium metal batteries in the range of −60 to 60 °C.

Fluorophores typically emit either in solution or in solid state due to several distinct effects. Here, the authors design a single-benzene fluorophore with efficient emission in both phases, enabling applications in photocatalysis and optical waveguiding.

Induction of hypothermia during hibernation/torpor enables certain mammals to survive under extreme conditions. Here, the authors show that the natural product P57 induces hypothermia by targeting pyridoxal kinase and has a potential application in therapeutic hypothermia.

MassCube improves data processing for nontargeted metabolomics LC-MS/MS analyses. Its peak detection achieves 100% signal coverage and outperforms other software for speed, isomer detection, and accuracy, benchmarked against past studies and new types of MS/MS data.

Allele-preferential transcription factor binding can influence pancreatic ductal adenocarcinoma risk loci function. Here, the authors show allele-specific JunB and JunD binding at chr1p36.33 and propose a role for KLHL17 in protein homeostasis by mitigating inflammation.

A CRISPR knock-in strategy that uses endogenous gene regulatory mechanisms can engineer ‘armoured’ CAR T cells that secrete proinflammatory cytokines directly within a tumour without causing toxicity, leading to prolonged survival in mice.

Scintillators are used for converting X-ray energy into visible light in imaging technologies. Here, the authors present a scalable fabrication approach for large-area nanostructured scintillators, and achieve six-fold enhancement in light yield compared to unpatterned scintillators.

The authors report a dual photothermal-electrocatalysis interface which enables efficient ammonia extraction and purification from air and wastewater, thereby advancing sustainable waste-to-fuel conversion.

Electroreduction of low-concentration NO₃⁻ to NH₃ is limited by NO₃⁻ mass transfer. Here, the authors propose a strategy for NO₃ ⁻ enrichment through charge rearrangement within the inner Helmholtz plane, achieving near-unity conversion of NO₃⁻ to NH₃.

Black phosphorus (BP) is considered a promising van der Waals material for the realization of mid-infrared detectors. Here, the authors report the realization of flexible infrared imagers based on solution-processed BP photodiodes on thin plastic substrates, showing long term stability and mechanical robustness.

A comprehensive analysis of the cell-specific molecular regulatory mechanisms underlying post-traumatic stress disorder in the human prefrontal cortex.

Spintronics has made great progress with switching and control of magnetization with charge currents, however, the fundamental issue of joule heating remains. Here, Choi, Ha, and coauthors demonstrate magnetization switching driven by magnonic spin dissipation in an antiferromagnet/ferromagnet bilayer structure.

Here, the authors present cryo-EM structures of Anhydromuropeptide permease in apo-inward, apo-outward, inward-occluded, and an outward-facing substrate, providing mechanistic insights into muropeptide translocation.

Clarke et al. identify chromatin factor ZNF280A, which is recruited to damaged chromatin where it promotes long-range DNA-end resection. Loss of ZNF280A is linked to genome instability in patients with 22q11.2 distal deletion syndrome.

The role of vascular plasticity in brain function remains poorly understood. Here, the authors demonstrate that a significant portion of blood vessels in the adult brain periodically occlude and regress, a process that is associated with a reduction in neuronal activity.

The epigenetic mechanisms underlying phenotypic diversity across different metastatic sites in castration-resistant prostate cancer (CRPC) remain to be characterised. Here, multi-omic profiling across metastatic lesions identifies regulatory networks driving tumour lineage programs and potential therapeutic targets.

Epstein-Barr virus is associated with increased cancer risk. Here, the authors analysed two population-based prospective cohorts in Southern China to examine the association between increased seropositivity and the risk of multiple cancer types.

Chronic care manages long-term, progressive conditions, while acute care handles short-term ones. Here, authors show chronic conditions account for most of the global health burden, with 68% of DALYs and 93% of YLDs attributed to chronic care needs.

Seawater electrolysis for hydrogen production faces challenges in creating robust anodes that resist corrosion. Here, the authors report a PW₁₂-polyoxometalate-modified CoFe hydroxide anode that achieves selective and durable seawater oxidation over 1300 hours at 1 A cm⁻².

Comparison of genome-wide association studies of HTT CAG repeat expansion in blood to expansion-driven clinical traits in Huntington’s disease identifies shared and distinct modifiers implicating DNA mismatch repair with tissue and cell-type specificity.

Arginine addiction induced by argininosuccinate synthase (ASSN1) deficiency has been exploited to treat ASS1-deficient cancers. Here, the authors show an alternative therapeutic approach where ASS1 activity is increased by the pesticide spinosyn A and is shown to inhibit breast cancer cell proliferation.

Wan, J. Shi, M. Shi, Huang et al. report a role for lactate dehydrogenase B in regulating CD8⁺ T cell disulfidptosis and exhaustion through the activity of glucose-6-phosphate dehydrogenase, thereby impacting the efficacy of antitumour immunity.

NatD is an acetyltransferase responsible for N-α-terminal acetylation of the histone H4 and H2A and has been linked to cell growth. Here the authors show that NatD-mediated acetylation of histone H4 serine 1 competes with the phosphorylation by CK2α at the same residue thus leading to the upregulation of Slug and tumor progression.

Anode-free lithium batteries are hindered by lithium inventory loss from parasitic interfacial reactions, cathode degradation, and limited Li⁺ reversibility. Here, authors propose a prelithiation separator engineering to enable multiscale interfacial stabilization in Ah-class anode-free pouch cells.

Aging impairs muscle and bone health, and exercise is known to mitigate this decline, partly through secreted factors. Here, the authors show that the muscle-derived factor CLCF1, which declines with age but is restored by exercise, mediates musculoskeletal benefits in aged mice.

Here the authors immobilize quaternary ammonium cations on the surface of Cu catalyst to suppress the carbonate precipitation, achieving a Faradaic efficiency of 50% for ethylene product at 200 mA/cm² from CO₂ electroreduction.

Non-shivering thermogenesis in brown adipose tissue (BAT) is tightly controlled by innervation. Here, the authors show that BAT-derived OLFM4 regulates Schwann cell differentiation through activation of the BMP7-MEK/ERK pathway, thereby modulating sensory and sympathetic innervation

In ABA trilayer graphene, a temperature gradient generates a transverse voltage that scales quadratically with the gradient and reaches an effective Nernst coefficient of 300 µV K⁻¹ near the charge neutrality point.

A variational-autoencoder-based diffusion architecture that enables topological controls on the diffusion-based protein structure generation is proposed. As a result, novel folds of mainly beta proteins can be designed with experimental validation.

Single atom catalysts offer a promising approach for CO₂ electroreduction to CO, but achieving high efficiency remains challenging. Here, the authors report lanthanide single atom catalysts with the transition ability from bridge to linear adsorption that exhibit efficient CO production.

The germline is established during embryogenesis when primordial germ cells are first specified. Here they show that the RNA-binding proteins DND1 and NANOS3 function together to repress the translation of SOX4, restricting the germ cell lineage specification during embryonic development.

TNF inhibitor (TNFi) has been used to manage active inflammation in ankylosing spondylitis (AS), but not all patients respond. Here, through longitudinal and multi-omics profiling, the authors show that elevated type-I IFN signature and allograft inflammatory factor-1 expression at baseline inversely correlate with TNFi responsiveness in AS patients.

Aqueous zinc-bromine flow batteries show promise for grid storage but suffer from zinc dendrite growth and hydrogen evolution reaction. Here, authors develop a reversible carbon felt electrode with Pb nanoparticles to suppress these issues, improving battery performance and cycle stability.

Targeted degradation has the potential to treat diseases associated with pathological protein build up. Here, the authors report on an oligo-PROTAC which degrades FUS, a protein associated with frontotemporal dementia, demonstrating delivery on DNA nanoflowers for increase blood-brain barrier crossing and retention.

X-ray synchrotron measurements reveal heterogeneities at electrode|electrolyte interfaces of lithium metal batteries operating at high potentials. Here the authors demonstrate the rearrangement of ionically conductive phases in polymer electrolytes that lead to battery performance degradation.

The quality of the Li–electrolyte interface is key to solid-state battery performance, especially at low pressure. Here, authors use operando electron microscopy to reveal how Li-Mg alloy anodes improve interfacial contact and low-pressure cycling stability by suppressing void formation.

Electrosynthesis of acetate from CO using renewable electricity faces low selectivity. Here, the authors report a cerium single atom modulated copper catalyst, where cerium atoms tailor the interfacial water structure, enabling highly selective CO-to-acetate conversion under pulsed electrolysis.

The Somatic Mosaicism across Human Tissues Network aims to create a reference catalogue of somatic mosaicism across different tissues and cells within individuals.

The specific energy and cycle life of rechargeable non-aqueous Na-based batteries are influenced by the type of electrolyte used. Here the authors propose a sulfonyl imide-rich electrolyte solution to improve the energy content and life span of various Na-based batteries.

New fern transcriptomes reveal repeated whole-genome duplications, unique gene families and distinct lignocellulosic evolution, providing a comprehensive database that underscores the ancient divergence and genetic uniqueness of ferns.

Impaired mitochondrial long-chain fatty acid β-oxidation (mtLCFAO) in type 2 alveolar epithelial (AT2) cells is thought to aggravate alveolar inflammation in acute lung injury. Here, the authors show that the mtLCFAO rate limiting enzyme CPT1a is decreased in AT2 cells in acute respiratory distress syndrome, highlighting the role of mtLCFAO in immunometabolism in this context.

Graphene multilayers can host heavy electrons in flat bands alongside light electrons in Dirac cones. Local probes now reveal that a finite Dirac electron population persists at the Fermi level while correlated states form in the flat bands.

Oxide ceramic electrolytes for Li-metal batteries often require high-temperature processing, which can compromise material reliability. Here, the authors present a sintering-free approach to synthesize disorder-driven garnet-type solid electrolytes, achieving performance comparable to traditional sintered materials.

Some thiamine diphosphate-dependent enzymes are powerful biocatalysts, forming carbon–carbon bonds between two α-keto acids, but their catalytic properties have been poorly understood. Now the substrate selectivity and catalytic stereoselectivity of two representative enzymes, CsmA and BbmA, have been fully characterized. Enzymatic total synthesis using these enzymes generates diverse carboligation products.