Nature Search

GLS2 links glutamine metabolism and atherosclerosis by remodeling artery walls

Murcy et al. show that increasing the plasma glutamine-to-glutamate ratio in atherosclerosis can distally reprogram transcriptional and post-transcriptional remodeling of the aorta by GLS2-dependent hepatic glutaminolysis.

Florent Murcy
Coraline Borowczyk
Laurent Yvan-Charvet
Research19 Nov 2024
Nature Cardiovascular Research

Volume: 3, P: 1454-1467
Single-cell RNA sequencing reveals sex differences in the subcellular composition and associated gene-regulatory network activity of human carotid plaques

Using deep sequencing of human carotid plaque cells from male and female patients with carotid stenosis, Sukhavasi et al. identify sex-biased cell-type-specific gene-regulatory networks and different phenotypes in smooth muscle cells, including an osteogenic phenotype in females and a chondrocytic phenotype in males.

Katyayani Sukhavasi
Giuseppe Mocci
Johan L. M. Björkegren
ResearchOpen Access10 Apr 2025
Nature Cardiovascular Research

Volume: 4, P: 412-432
Integrative multi-omics profiling in human decedents receiving pig heart xenografts

Multi-omics profiling of the blood and heart of two human decedents receiving pig heart xenografts, including single-cell studies, reveals early immune responses and perioperative cardiac xenograft dysfunction in one of the two decedents, which may be due to mismatched heart size and/or insufficient immunosuppression.

Eloi Schmauch
Brian Piening
Brendan J. Keating
Research17 May 2024
Nature Medicine

Volume: 30, P: 1448-1460
Elevated circulating follistatin associates with an increased risk of type 2 diabetes

Follistatin promotes in type 2 diabetes (T2D) pathogenesis in model animals and is elevated in patients with T2D. Here the authors report that plasma follistatin associates with increased risk of incident T2D in two longitudinal cohorts, and show that follistatin regulates insulin-induced suppression lipolysis in cultured human adipocytes.

Chuanyan Wu
Yan Borné
Yang De Marinis
ResearchOpen Access10 Nov 2021
Nature Communications

Volume: 12, P: 1-10
The angiopoietin receptor Tie2 is atheroprotective in arterial endothelium

Anisimov, Fang et al. report that in humans, genetic variants associated with higher TIE2 expression are predicted to confer a reduced risk of CAD; in mice, Tie2 expression in endothelial cells is atheroprotective, and in a subset of aortic fibroblasts, anti-inflammatory.

Andrey Anisimov
Shentong Fang
Kari Alitalo
ResearchOpen Access13 Mar 2023
Nature Cardiovascular Research

Volume: 2, P: 307-321
Control of inducible gene expression links cohesin to hematopoietic progenitor self-renewal and differentiation

Cohesin is a chromatin-binding factor that interacts at CTCF motifs to organize chromatin looping domains. Merkenschlager and colleagues show that cohesin regulates the inducible expression of inflammatory genes in macrophages and HSPCs and in human AML.

Sergi Cuartero
Felix D. Weiss
Matthias Merkenschlager
Research20 Aug 2018
Nature Immunology

Volume: 19, P: 932-941
Transcription factor Nr4a1 couples sympathetic and inflammatory cues in CNS-recruited macrophages to limit neuroinflammation

Stress can induce expression of norepinephrine, which can enhance neuroinflammation. Shaked, Hedrick and colleagues show that the transcriptional repressor Nr4a1 limits this stress-induced response by suppressing expression of tyrosine hydroxylase required for the synthesis of norepinephrine.

Iftach Shaked
Richard N Hanna
Catherine C Hedrick
Research01 Dec 2015
Nature Immunology

Volume: 16, P: 1228-1234
Rev-Erbs repress macrophage gene expression by inhibiting enhancer-directed transcription

It is unclear whether bidirectional non-coding RNAs transcribed from enhancer elements (eRNAs) have any functional role; here, the repressive functions of Rev-Erb nuclear receptors in macrophages are shown to be linked to their ability to inhibit the transcription of eRNAs.

Michael T. Y. Lam
Han Cho
Christopher K. Glass
Research02 Jun 2013
Nature

Volume: 498, P: 511-515
Extensive reprogramming of the nascent transcriptome during iPSC to hepatocyte differentiation

Leena E. Viiri
Tommi Rantapero
Katriina Aalto-Setälä
ResearchOpen Access05 Mar 2019
Scientific Reports

Volume: 9, P: 1-12
Reprogramming transcription by distinct classes of enhancers functionally defined by eRNA

Dong Wang
Ivan Garcia-Bassets
Xiang-Dong Fu
Research15 May 2011
Nature

Volume: 474, P: 390-394
Snake venom VEGF Vammin induces a highly efficient angiogenic response in skeletal muscle via VEGFR-2/NRP specific signaling

Pyry I. Toivanen
Tiina Nieminen
Seppo Ylä-Herttuala
ResearchOpen Access17 Jul 2017
Scientific Reports

Volume: 7, P: 1-12
Functional Variant in the GCKR Gene Affects Lactate Levels Differentially in the Fasting State and During Hyperglycemia

Maykel López Rodríguez
Lilian Fernandes Silva
Markku Laakso
ResearchOpen Access30 Oct 2018
Scientific Reports

Volume: 8, P: 1-8
Quantification of nascent transcription by bromouridine immunocapture nuclear run-on RT-qPCR

Roberts et al. describe how to measure transcriptional activity using nuclear run-on RT-qPCR assays. The approach is ideal for analyzing a single gene (or small number of genes) or for follow-up or validation of genome-wide analyses.

Thomas C Roberts
Jonathan R Hart
Kevin V Morris
Protocols16 Jul 2015
Nature Protocols

Volume: 10, P: 1198-1211
Radiosynthesis and preclinical evaluation of [⁶⁸Ga]Ga-NOTA-folate for PET imaging of folate receptor β-positive macrophages

Olli Moisio
Senthil Palani
Anne Roivainen
ResearchOpen Access12 Aug 2020
Scientific Reports

Volume: 10, P: 1-10
The proapoptotic gene interferon regulatory factor-1 mediates the antiproliferative outcome of paired box 2 gene and tamoxifen

Shixiong Wang
Venkata S. Somisetty
Antoni Hurtado
ResearchOpen Access25 Aug 2020
Oncogene

Volume: 39, P: 6300-6312
Global analysis of transcription in castration-resistant prostate cancer cells uncovers active enhancers and direct androgen receptor targets

Sari Toropainen
Einari A. Niskanen
Jorma J. Palvimo
ResearchOpen Access19 Sept 2016
Scientific Reports

Volume: 6, P: 1-12

Search

GLS2 links glutamine metabolism and atherosclerosis by remodeling artery walls

Single-cell RNA sequencing reveals sex differences in the subcellular composition and associated gene-regulatory network activity of human carotid plaques

Integrative multi-omics profiling in human decedents receiving pig heart xenografts

Elevated circulating follistatin associates with an increased risk of type 2 diabetes

The angiopoietin receptor Tie2 is atheroprotective in arterial endothelium

Control of inducible gene expression links cohesin to hematopoietic progenitor self-renewal and differentiation

Transcription factor Nr4a1 couples sympathetic and inflammatory cues in CNS-recruited macrophages to limit neuroinflammation

Rev-Erbs repress macrophage gene expression by inhibiting enhancer-directed transcription

Extensive reprogramming of the nascent transcriptome during iPSC to hepatocyte differentiation

Reprogramming transcription by distinct classes of enhancers functionally defined by eRNA

Snake venom VEGF Vammin induces a highly efficient angiogenic response in skeletal muscle via VEGFR-2/NRP specific signaling

Functional Variant in the GCKR Gene Affects Lactate Levels Differentially in the Fasting State and During Hyperglycemia

Quantification of nascent transcription by bromouridine immunocapture nuclear run-on RT-qPCR

Radiosynthesis and preclinical evaluation of [⁶⁸Ga]Ga-NOTA-folate for PET imaging of folate receptor β-positive macrophages

The proapoptotic gene interferon regulatory factor-1 mediates the antiproliferative outcome of paired box 2 gene and tamoxifen

Global analysis of transcription in castration-resistant prostate cancer cells uncovers active enhancers and direct androgen receptor targets

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