Nature Search

Expression of Structurally Unaltered Androgen Receptor in Extramammary Paget's Disease

Akihide Fujimoto
Minoru Takata
Kazuhiko Takehara
Research01 Sept 2000
Laboratory Investigation

Volume: 80, P: 1465-1471
Efficient rejoining of radiation-induced DNA double-strand breaks in vertebrate cells deficient in genes of the RAD52 epistasis group

Huichen Wang
Zhao-Chong Zeng
George Iliakis
Research26 Apr 2001
Oncogene

Volume: 20, P: 2212-2224
The whole blood transcriptional regulation landscape in 465 COVID-19 infected samples from Japan COVID-19 Task Force

Genetic mechanisms influencing COVID-19 susceptibility are not well understood. Here, the authors analyzed whole blood RNA-seq data of 465 Japanese individuals with COVID-19, highlighting thousands of fine-mapped variants affecting expression and splicing of genes, as well as the presence of COVID-19 severity-interaction eQTLs.

Qingbo S. Wang
Ryuya Edahiro
Yukinori Okada
ResearchOpen Access22 Aug 2022
Nature Communications

Volume: 13, P: 1-19
DOCK2 is involved in the host genetics and biology of severe COVID-19

A genome-wide association study highlights a variant in DOCK2, which is common in East Asian populations but rare in Europeans, as a host genetic risk factor for severe COVID-19.

Ho Namkoong
Ryuya Edahiro
Yukinori Okada
ResearchOpen Access08 Aug 2022
Nature

Volume: 609, P: 754-760
Blood DNA virome associates with autoimmune diseases and COVID-19

Analysis of the blood DNA virome in patients with COVID-19 and autoimmune disease associates endogenous HHV-6 (eHHV-6) and high anellovirus load with increased disease risk, most notably for systemic lupus erythematosus. eHHV-6 carriers show a distinct immune response.

Noah Sasa
Shohei Kojima
Yukinori Okada
ResearchOpen Access03 Jan 2025
Nature Genetics

Volume: 57, P: 65-79
YAP determines the cell fate of injured mouse hepatocytes in vivo

Senescent and injured cells affect tissue functions and can drive tumorigenesis. Thus, efficient elimination of these cells is pivotal for tissue integrity. Here Miyamuraet al. show that YAP acts as a cellular stress sensor and promotes the elimination of damaged cells to maintain tissue homeostasis.

Norio Miyamura
Shoji Hata
Hiroshi Nishina
ResearchOpen Access06 Jul 2017
Nature Communications

Volume: 8, P: 1-10
Mapping the human genetic architecture of COVID-19

A global network of researchers was formed to investigate the role of human genetics in SARS-CoV-2 infection and COVID-19 severity; this paper reports 13 genome-wide significant loci and potentially actionable mechanisms in response to infection.

Mari E. K. Niemi
Juha Karjalainen
Chloe Donohue
ResearchOpen Access08 Jul 2021
Nature

Volume: 600, P: 472-477
Common variants at 11q12, 10q26 and 3p11.2 are associated with prostate cancer susceptibility in Japanese

Hidewaki Nakagawa and colleagues identify three new genetic loci associated with prostate cancer in Japanese.

Shusuke Akamatsu
Ryo Takata
Hidewaki Nakagawa
Research26 Feb 2012
Nature Genetics

Volume: 44, P: 426-429
Ablation of XRCC2/3 transforms immunoglobulin V gene conversion into somatic hypermutation

Julian E. Sale
Daniella M. Calandrini
Michael S. Neuberger
Research30 Aug 2001
Nature

Volume: 412, P: 921-926
Formaldehyde catabolism is essential in cells deficient for the Fanconi anemia DNA-repair pathway

The Fanconi anemia (FA) DNA-repair pathway is important in processing of DNA interstrand cross-links and in resistance to exogenously added aldehyde. Genetic analyses now reveal the synthetic lethality of deficiencies in the FA pathway and formaldehyde catabolism, indicting that this pathway repairs lesions caused by endogenous formaldehyde.

Ivan V Rosado
Frédéric Langevin
Ketan J Patel
Research13 Nov 2011
Nature Structural & Molecular Biology

Volume: 18, P: 1432-1434
Thermoresponsive actuation enabled by permittivity switching in an electrostatically anisotropic hydrogel

The temperature-mediated modulation of anisotropic electrostatics in response to changes of electrostatic permittivity in a hydrogel consisting of cofacially oriented electrolyte nanosheets imparts the hydrogel with actuation properties.

Youn Soo Kim
Mingjie Liu
Takuzo Aida
Research10 Aug 2015
Nature Materials

Volume: 14, P: 1002-1007
Nbs1 is essential for DNA repair by homologous recombination in higher vertebrate cells

Hiroshi Tauchi
Junya Kobayashi
Kenshi Komatsu
Research07 Nov 2002
Nature

Volume: 420, P: 93-98
Single-cell analyses and host genetics highlight the role of innate immune cells in COVID-19 severity

Peripheral blood mononuclear cells from 73 Japanese patients with coronavirus disease 2019 (COVID-19) and 75 healthy controls were analyzed using single-cell transcriptomics. Combining these data with genotyping data highlights the interplay between host genetics and the immune response in modulating disease severity.

Ryuya Edahiro
Yuya Shirai
Yukinori Okada
ResearchOpen Access24 Apr 2023
Nature Genetics

Volume: 55, P: 753-767
Prognostic significance of allelic losses in primary melanoma

Eugene Healy
Christine Belgaid
Jonathan L Rees
Research15 May 1998
Oncogene

Volume: 16, P: 2213-2218
Conserved domains in the chicken homologue of BRCA2

Minoru Takata
Seiji Tachiiri
Mitsuyoshi Yamazoe
Research18 Feb 2002
Oncogene

Volume: 21, P: 1130-1134
Fanconi anemia proteins participate in a break-induced-replication-like pathway to counter replication stress

Cell-based, in vitro and in vivo assays reveal that Fanconi anemia factors function in a BRCA1-dependent BIR-like pathway to restart stalled replication forks and that persistent replication stress contributes to FA pathogenesis.

Xinlin Xu
Yixi Xu
Dongyi Xu
Research10 Jun 2021
Nature Structural & Molecular Biology

Volume: 28, P: 487-500
A second update on mapping the human genetic architecture of COVID-19

Masahiro Kanai
Shea J. Andrews
Matthew Solomonson
ResearchOpen Access06 Sept 2023
Nature

Volume: 621, P: E7-E26
FANCI phosphorylation functions as a molecular switch to turn on the Fanconi anemia pathway

The Fanconi anemia pathway is involved in the signaling of DNA damage. Several Fanconi anemia proteins have been identified, but how the pathway is actually activated was unclear. Now, work on chicken DT40 cells indicates that phosphorylation of FANCI at multiple sites triggers FANCD2 monoubiquitination and DNA-damage repair.

Masamichi Ishiai
Hiroyuki Kitao
Minoru Takata
Research19 Oct 2008
Nature Structural & Molecular Biology

Volume: 15, P: 1138-1146
Translational research of boron neutron capture therapy for spinal cord gliomas using rat model

Ryo Kayama
Kohei Tsujino
Masahiko Wanibuchi
ResearchOpen Access09 Apr 2024
Scientific Reports

Volume: 14, P: 1-11
p16^INK4a inactivation is not frequent in uncultured sporadic primary cutaneous melanoma

Akihide Fujimoto
Reiji Morita
Minoru Takata
Research15 Apr 1999
Oncogene

Volume: 18, P: 2527-2532
Clinical utility of next-generation sequencing for inherited bone marrow failure syndromes

Hideki Muramatsu
Yusuke Okuno
Seiji Kojima
Research19 Jan 2017
Genetics in Medicine

Volume: 19, P: 796-802
Mouse Slfn8 and Slfn9 genes complement human cells lacking SLFN11 during the replication stress response

Expression of the mouse genes, Slfn8 and Slfn9, can complement human SLFN11 loss in human SLFN11-null cells, reducing the growth rate to wild-type levels and partially restoring sensitivity to DNA-damaging agents.

Erin Alvi
Ayako L. Mochizuki
Anfeng Mu
ResearchOpen Access13 Oct 2023
Communications Biology

Volume: 6, P: 1-12
5-Aminolevulinic acid increases boronophenylalanine uptake into glioma stem cells and may sensitize malignant glioma to boron neutron capture therapy

Masao Fukumura
Naosuke Nonoguchi
Masahiko Wanibuchi
ResearchOpen Access22 Jun 2023
Scientific Reports

Volume: 13, P: 1-11
Cells sorted off hiPSC-derived kidney organoids coupled with immortalized cells reliably model the proximal tubule

A microfluidic device can help analyse the functions of pseudo proximal tubule cells coming from hiPSC-derived kidney organoids, with the future potential for applications in personalized nephrotoxicity studies.

Ramin Banan Sadeghian
Ryohei Ueno
Ryuji Yokokawa
ResearchOpen Access04 May 2023
Communications Biology

Volume: 6, P: 1-17
Influence of hospital capabilities and prehospital time on outcomes of thrombectomy for stroke in Japan from 2013 to 2016

Ai Kurogi
Daisuke Onozuka
Masayuki Yokota
ResearchOpen Access28 Feb 2022
Scientific Reports

Volume: 12, P: 1-17
Persistent elevation of lysophosphatidylcholine promotes radiation brain necrosis with microglial recruitment by P2RX4 activation

Natsuko Kondo
Yoshinori Sakurai
Minoru Suzuki
ResearchOpen Access24 May 2022
Scientific Reports

Volume: 12, P: 1-14
USP42 enhances homologous recombination repair by promoting R-loop resolution with a DNA–RNA helicase DHX9

Misaki Matsui
Ryo Sakasai
Ryotaro Nishi
ResearchOpen Access15 Jun 2020
Oncogenesis

Volume: 9, P: 1-13
Bloom syndrome complex promotes FANCM recruitment to stalled replication forks and facilitates both repair and traverse of DNA interstrand crosslinks

Chen Ling
Jing Huang
Weidong Wang
ResearchOpen Access20 Dec 2016
Cell Discovery

Volume: 2, P: 1-18
Clinicopathological and genomic analysis of double-hit follicular lymphoma: comparison with high-grade B-cell lymphoma with MYC and BCL2 and/or BCL6 rearrangements

Masashi Miyaoka
Yara Y Kikuti
Naoya Nakamura
Research06 Oct 2017
Modern Pathology

Volume: 31, P: 313-326
Genomic and immunohistochemical profiles of enteropathy-associated T-cell lymphoma in Japan

Sakura Tomita
Yara Y Kikuti
Naoya Nakamura
Research31 Jul 2015
Modern Pathology

Volume: 28, P: 1286-1296
Similar protein expression profiles of ovarian and endometrial high-grade serous carcinomas

Kosuke Hiramatsu
Kiyoshi Yoshino
Tadashi Kimura
ResearchOpen Access18 Feb 2016
British Journal of Cancer

Volume: 114, P: 554-561

Search

Expression of Structurally Unaltered Androgen Receptor in Extramammary Paget's Disease

Efficient rejoining of radiation-induced DNA double-strand breaks in vertebrate cells deficient in genes of the RAD52 epistasis group

The whole blood transcriptional regulation landscape in 465 COVID-19 infected samples from Japan COVID-19 Task Force

DOCK2 is involved in the host genetics and biology of severe COVID-19

Blood DNA virome associates with autoimmune diseases and COVID-19

YAP determines the cell fate of injured mouse hepatocytes in vivo

Mapping the human genetic architecture of COVID-19

Common variants at 11q12, 10q26 and 3p11.2 are associated with prostate cancer susceptibility in Japanese

Ablation of XRCC2/3 transforms immunoglobulin V gene conversion into somatic hypermutation

Formaldehyde catabolism is essential in cells deficient for the Fanconi anemia DNA-repair pathway

Thermoresponsive actuation enabled by permittivity switching in an electrostatically anisotropic hydrogel

Nbs1 is essential for DNA repair by homologous recombination in higher vertebrate cells

Single-cell analyses and host genetics highlight the role of innate immune cells in COVID-19 severity

Prognostic significance of allelic losses in primary melanoma

Conserved domains in the chicken homologue of BRCA2

Fanconi anemia proteins participate in a break-induced-replication-like pathway to counter replication stress

A second update on mapping the human genetic architecture of COVID-19

FANCI phosphorylation functions as a molecular switch to turn on the Fanconi anemia pathway

Translational research of boron neutron capture therapy for spinal cord gliomas using rat model

p16^INK4a inactivation is not frequent in uncultured sporadic primary cutaneous melanoma

Clinical utility of next-generation sequencing for inherited bone marrow failure syndromes

Mouse Slfn8 and Slfn9 genes complement human cells lacking SLFN11 during the replication stress response

5-Aminolevulinic acid increases boronophenylalanine uptake into glioma stem cells and may sensitize malignant glioma to boron neutron capture therapy

Cells sorted off hiPSC-derived kidney organoids coupled with immortalized cells reliably model the proximal tubule

Influence of hospital capabilities and prehospital time on outcomes of thrombectomy for stroke in Japan from 2013 to 2016

Persistent elevation of lysophosphatidylcholine promotes radiation brain necrosis with microglial recruitment by P2RX4 activation

USP42 enhances homologous recombination repair by promoting R-loop resolution with a DNA–RNA helicase DHX9

Bloom syndrome complex promotes FANCM recruitment to stalled replication forks and facilitates both repair and traverse of DNA interstrand crosslinks

Clinicopathological and genomic analysis of double-hit follicular lymphoma: comparison with high-grade B-cell lymphoma with MYC and BCL2 and/or BCL6 rearrangements

Genomic and immunohistochemical profiles of enteropathy-associated T-cell lymphoma in Japan

Similar protein expression profiles of ovarian and endometrial high-grade serous carcinomas

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