Nature Search

Methylome-wide association study of antidepressant use in Generation Scotland and the Netherlands Twin Register implicates the innate immune system

Miruna C. Barbu
Floris Huider
Andrew M. McIntosh
ResearchOpen Access08 Dec 2021
Molecular Psychiatry

Volume: 27, P: 1647-1657
Integrated methylome and phenome study of the circulating proteome reveals markers pertinent to brain health

Characterising associations between the methylome, proteome and phenome may provide insight into biological pathways governing brain health. Here, blood protein markers of brain health are integrated with omics data to reveal DNA methylation differences that associate with these protein markers.

Danni A. Gadd
Robert F. Hillary
Riccardo E. Marioni
ResearchOpen Access09 Aug 2022
Nature Communications

Volume: 13, P: 1-14
Author Correction: Genome-wide association study of depression phenotypes in UK Biobank identifies variants in excitatory synaptic pathways

David M. Howard
Mark J. Adams
Andrew M. McIntosh
Amendments and CorrectionsOpen Access25 Mar 2021
Nature Communications

Volume: 12, P: 1
Genome-wide meta-analysis of depression identifies 102 independent variants and highlights the importance of the prefrontal brain regions

The authors conducted a genetic meta-analysis of depression and found 269 associated genes. These genes highlight several potential drug repositioning opportunities, and relationships with depression were found for neuroticism and smoking.

David M. Howard
Mark J. Adams
Andrew M. McIntosh
Research04 Feb 2019
Nature Neuroscience

Volume: 22, P: 343-352
Addendum: Genome-wide association study of depression phenotypes in UK Biobank identifies variants in excitatory synaptic pathways

David M. Howard
Mark J. Adams
Andrew M. McIntosh
Amendments and CorrectionsOpen Access30 Aug 2018
Nature Communications

Volume: 9, P: 1-3
Genome-wide association study of depression phenotypes in UK Biobank identifies variants in excitatory synaptic pathways

The UK Biobank provides data for three depression-related phenotypes. Here, Howard et al. perform a genome-association study for broad depression, probable major depressive disorder (MDD) and hospital record-coded MDD in up to 322,580 UK Biobank participants which highlights excitatory synaptic pathways.

David M. Howard
Mark J. Adams
Andrew M. McIntosh
ResearchOpen Access16 Apr 2018
Nature Communications

Volume: 9, P: 1-10
Correction: Structural neuroimaging measures and lifetime depression across levels of phenotyping in UK biobank

Mathew A. Harris
Simon R. Cox
Heather C. Whalley
Amendments and CorrectionsOpen Access14 Jul 2022
Translational Psychiatry

Volume: 12, P: 1
Epigenome-wide association study of alcohol consumption in N = 8161 individuals and relevance to alcohol use disorder pathophysiology: identification of the cystine/glutamate transporter SLC7A11 as a top target

Falk W. Lohoff
Toni-Kim Clarke
Kathryn L. Evans
ResearchOpen Access02 Dec 2021
Molecular Psychiatry

Volume: 27, P: 1754-1764
Hair glucocorticoids are associated with childhood adversity, depressive symptoms and reduced global and lobar grey matter in Generation Scotland

Claire Green
Aleks Stolicyn
Heather C. Whalley
ResearchOpen Access12 Oct 2021
Translational Psychiatry

Volume: 11, P: 1-9
Epigenetic prediction of major depressive disorder

Miruna C. Barbu
Xueyi Shen
Andrew M. McIntosh
ResearchOpen Access10 Jun 2020
Molecular Psychiatry

Volume: 26, P: 5112-5123
Reversal of proliferation deficits caused by chromosome 16p13.11 microduplication through targeting NFκB signaling: an integrated study of patient-derived neuronal precursor cells, cerebral organoids and in vivo brain imaging

Mandy Johnstone
Navneet A. Vasistha
Siddharthan Chandran
ResearchOpen Access06 Nov 2018
Molecular Psychiatry

Volume: 24, P: 294-311
Grey and white matter associations of psychotic-like experiences in a general population sample (UK Biobank)

Julie Schoorl
Miruna C. Barbu
Stephen M. Lawrie
ResearchOpen Access07 Jan 2021
Translational Psychiatry

Volume: 11, P: 1-11
Structural neuroimaging measures and lifetime depression across levels of phenotyping in UK biobank

Mathew A. Harris
Simon R. Cox
Heather C. Whalley
ResearchOpen Access13 Apr 2022
Translational Psychiatry

Volume: 12, P: 1-9
Expression quantitative trait loci-derived scores and white matter microstructure in UK Biobank: a novel approach to integrating genetics and neuroimaging

Miruna C. Barbu
Athina Spiliopoulou
Heather C. Whalley
ResearchOpen Access04 Feb 2020
Translational Psychiatry

Volume: 10, P: 1-12

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