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PIN1-SUMO2/3 motif suppresses excessive RNF168 chromatin accumulation and ubiquitin signaling to promote IR resistance

The ubiquitin ligase, RNF168, promotes DNA break repair but must be regulated to prevent run-away ubiquitin signaling. Here, the authors identify a three-step post-translational cascade regulating RNF168 chromatin removal, acting to suppress excessive signaling and radiosensitivity.

Anoop S. Chauhan
Matthew J. W. Mackintosh
Joanna R. Morris
ResearchOpen Access14 Apr 2025
Nature Communications

Volume: 16, P: 1-18
Evidence for phospholipid export from the bacterial inner membrane by the Mla ABC transport system

A combination of structural and biochemical analyses of MlaC, the soluble periplasmic component of the Mla pathway, elucidate how this protein assists phospholipid movement between the bacterial inner and outer membranes.

Gareth W. Hughes
Stephen C. L. Hall
Timothy J. Knowles
Research24 Jun 2019
Nature Microbiology

Volume: 4, P: 1692-1705
A method for detergent-free isolation of membrane proteins in their local lipid environment

This protocol from Lee et al. describes a method for the extraction of membrane proteins in their native lipid environment using styrene maleic anhydride (SMA) co-polymer. The method is applicable to both prokaryotic and eukaryotic expression systems.

Sarah C Lee
Tim J Knowles
Timothy R Dafforn
Protocols02 Jun 2016
Nature Protocols

Volume: 11, P: 1149-1162
Isomerization of BRCA1–BARD1 promotes replication fork protection

BRCA1–BARD1 has a role in replication fork protection that is mediated by a mechanism of phosphorylation-targeted isomerization of BRCA1 and is independent of the canonical interaction between BRCA1 and PALB2.

Manuel Daza-Martin
Katarzyna Starowicz
Joanna R. Morris
Research03 Jul 2019
Nature

Volume: 571, P: 521-527
Nano-encapsulated Escherichia coli Divisome Anchor ZipA, and in Complex with FtsZ

Sarah C. Lee
Richard Collins
Timothy R. Dafforn
ResearchOpen Access10 Dec 2019
Scientific Reports

Volume: 9, P: 1-16
MCE ___domain proteins: conserved inner membrane lipid-binding proteins required for outer membrane homeostasis

Georgia L. Isom
Nathaniel J. Davies
Ian R. Henderson
ResearchOpen Access17 Aug 2017
Scientific Reports

Volume: 7, P: 1-12

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PIN1-SUMO2/3 motif suppresses excessive RNF168 chromatin accumulation and ubiquitin signaling to promote IR resistance

Evidence for phospholipid export from the bacterial inner membrane by the Mla ABC transport system

A method for detergent-free isolation of membrane proteins in their local lipid environment

Isomerization of BRCA1–BARD1 promotes replication fork protection

Nano-encapsulated Escherichia coli Divisome Anchor ZipA, and in Complex with FtsZ

MCE ___domain proteins: conserved inner membrane lipid-binding proteins required for outer membrane homeostasis

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