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Showing 1–6 of 6 results

Advanced filters: Author: Mor Zada Clear advanced filters

Identification of resistance pathways and therapeutic targets in relapsed multiple myeloma patients through single-cell sequencing

Integration of longitudinal single-cell analysis of relapsed and refractory multiple myeloma patients in a prospective clinical trial uncovers new pathways of drug resistance and identifies potential actionable targets.

Yael C. Cohen
Mor Zada
Ido Amit
Research22 Feb 2021
Nature Medicine

Volume: 27, P: 491-503
Modeling T cell temporal response to cancer immunotherapy rationalizes development of combinatorial treatment protocols

Through in vivo tracking of tumor-specific CD8⁺ T cells in response to immunotherapy in mice, Barboy et al. characterize the tumor response to anti-PD-1 therapy and optimize a combination treatment with anti-4-1BB agonist.

Oren Barboy
Akhiad Bercovich
Ido Amit
Research01 Mar 2024
Nature Cancer

Volume: 5, P: 742-759
The transcriptional and regulatory identity of erythropoietin producing cells

Single-cell analyses in a reporter mouse model and human tissues identify a rare cell subset that produces erythropoietin in vivo, opening potential new avenues for research in erythropoiesis and oxygen homeostasis.

Bjørt K. Kragesteen
Amir Giladi
Ido Amit
Research27 Apr 2023
Nature Medicine

Volume: 29, P: 1191-1200
Dissecting cellular crosstalk by sequencing physically interacting cells

PIC-seq characterizes cellular crosstalk by sorting and sequencing physically interacting cells.

Amir Giladi
Merav Cohen
Ido Amit
Research09 Mar 2020
Nature Biotechnology

Volume: 38, P: 629-637
The interaction of CD4⁺ helper T cells with dendritic cells shapes the tumor microenvironment and immune checkpoint blockade response

Amit and colleagues report that the specific interaction of a CD4⁺PD-1⁺CXCL13⁺ T-cell subset with antigen-presenting cells reprograms the tumor microenvironment and response to immune checkpoint inhibitors in non-small cell lung cancer.

Merav Cohen
Amir Giladi
Ido Amit
Research03 Mar 2022
Nature Cancer

Volume: 3, P: 303-317
Single cell dissection of plasma cell heterogeneity in symptomatic and asymptomatic myeloma

Single cell dissection of plasma cell heterogeneity in myeloma patients reveals new insights into disease that may inform early diagnosis and clinical management.

Guy Ledergor
Assaf Weiner
Ido Amit
Research06 Dec 2018
Nature Medicine

Volume: 24, P: 1867-1876