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Showing 1–7 of 7 results
Advanced filters: Author: Moritz Hunkeler Clear advanced filters
  • Acetyl-CoA carboxylases are central regulatory hubs of fatty acid metabolism and are important targets for drug development in obesity and cancer. Here, the authors demonstrate that the regulation of these highly dynamic enzymes in fungi is governed by a mechanism based on phosphorylation-dependent conformational variability.

    • Moritz Hunkeler
    • Edward Stuttfeld
    • Timm Maier
    ResearchOpen Access
    Nature Communications
    Volume: 7, P: 1-11
  • Cryo-electron microscopy studies of distinct, catalytically active and inactive filaments of human acetyl-CoA carboxylase 1 reveal the structural basis of its regulation.

    • Moritz Hunkeler
    • Anna Hagmann
    • Timm Maier
    Research
    Nature
    Volume: 558, P: 470-474
  • Characterization of DCAF16-based BRD4 molecular glue degraders revealed a trans-labeling mechanism termed ‘template-assisted covalent modification’, which opens a new path for proximity-driven pharmacology.

    • Yen-Der Li
    • Michelle W. Ma
    • Benjamin L. Ebert
    ResearchOpen Access
    Nature Chemical Biology
    Volume: 20, P: 1640-1649
  • Structures of the human METTL1–WDR4 complex are revealed, providing molecular insights into substrate recognition, modification and catalytic regulation by the N7-methylguanosine methyltransferase complex.

    • Jiazhi Li
    • Longfei Wang
    • Richard I. Gregory
    Research
    Nature
    Volume: 613, P: 391-397
  • Binding of the small molecule BI-3802 to the oncogenic transcription factor B cell lymphoma 6 (BCL6) induces polymerization of BCL6, leading to its ubiquitination by SIAH1 and proteasomal degradation.

    • MikoÅ‚aj SÅ‚abicki
    • Hojong Yoon
    • Benjamin L. Ebert
    Research
    Nature
    Volume: 588, P: 164-168