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Showing 1–2 of 2 results
Advanced filters: Author: Muaz Nik Rushdi Clear advanced filters

  • It is known that the T cell co-receptor CD4 greatly enhances the capacity of T cell receptor (TCR) signalling, triggered by the peptide-bound MHC molecule. Here authors show that the mechanistic basis for the enhancement is the co-operative binding of TCR and CD4 to the MHC-peptide complex.

    • Muaz Nik Rushdi
    • Victor Pan
    • Cheng Zhu
    ResearchOpen Access
    Nature Communications
    Volume: 13, P: 1-16

  • Catch bonds where lifetime increases with force applied can form when T cell receptors (TCR) interact with agonist peptide-MHC (pMHC) complexes. Here the authors use a modelling and experimental approach to analyse 55 TCR–pMHC bond lifetime curves measured under force to further characterise the structural bases and functional relevance of catch bonds.

    • Hyun-Kyu Choi
    • Peiwen Cong
    • Cheng Zhu
    ResearchOpen Access
    Nature Communications
    Volume: 14, P: 1-20