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Showing 1–4 of 4 results
Advanced filters: Author: Mylène Bohec Clear advanced filters

  • A scalable approach to explore DNA replication in single cells reveals that although aneuploidy does not have a major impact on the pattern of replication, different cell types and sub-populations display distinguished replication paths.

    • Stefano Gnan
    • Joseph M. Josephides
    • Chun-Long Chen
    ResearchOpen Access
    Nature Communications
    Volume: 13, P: 1-15

  • Single-cell multiomic profiling of triple-negative breast cancer samples treated with capecitabine shows that H3K27me3 regulates a persister cell state. Blocking H3K27me3 demethylation inhibits the transition to a drug-tolerant state and delays tumor recurrence.

    • Justine Marsolier
    • Pacôme Prompsy
    • Céline Vallot
    Research
    Nature Genetics
    Volume: 54, P: 459-468

  • Identifying novel therapies for the treatment of CDK4/6 inhibitor-resistant patients is of great importance. Here, the authors demonstrate that PLK1 inhibition is a potential therapeutic target in CCND1-driven and in RB-positive Palbociclib-resistant breast cancers.

    • Elodie Montaudon
    • Joanna Nikitorowicz-Buniak
    • Elisabetta Marangoni
    ResearchOpen Access
    Nature Communications
    Volume: 11, P: 1-16

  • Cross-presentation, or the presentation of exogenous antigens on MHC-I, is thought to be restricted to dendritic cells (DCs). Here the authors show that human DCs and macrophages developed in vivo from monocytes can both perform cross-presentation using a non-conventional pathway, but only DCs are capable of inducing cytotoxic CD8+ T cells.

    • Tsing-Lee Tang-Huau
    • Paul Gueguen
    • Elodie Segura
    ResearchOpen Access
    Nature Communications
    Volume: 9, P: 1-12