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Large volumes of true random numbers are needed for increasing requirements of secure data encryption. Here the authors use the stochastic nature of DNA synthesis to obtain millions of gigabytes of unbiased randomness.

The epigenetic and transcriptional roles of Nucleoporin 98 (NUP98) fusion oncoproteins in driving pediatric acute myeloid leukemia (AML) remain to be explored. Here, the authors identify a core set of genes regulated by NUP98::KDM5A and suggest CDK12 as a potential therapeutic vulnerability.

The Gaussian minimum entropy conjecture—a long-standing open question—has now been proved for single-mode phase-insensitive bosonic Gaussian channels. This establishes the ultimate achievable bit rate under an energy constraint and provides long-awaited proof that the single-letter classical capacity of these channels is additive.

Tuft cells constitutively express IL-25 to sustain ILC2 homeostasis in the intestine, but mechanisms driving IL-25 secretion have been unclear. Here, Feng et al. find that tuft cells express IL-17RB, which is required to regulate the bioavailability of IL-25 and to restrain the activation of ILC2s during homeostasis.

Here the authors identify TNIP1 as a risk factor for a fatal neurodegenerative disorder and discover specific genetic loci associated with the three main subtypes of this disorder. The findings highlight distinct disease mechanisms, emphasizing the roles of immunity and the notch signaling pathway.

Ferroelectric ___domain switching on the surface of a lithium niobate thin film can be induced by the tip of a scanning probe microscope, and gives rise to both regular and chaotic spatiotemporal patterns. Moreover, the long-range interactions that govern these phenomena can be tuned by varying temperature, humidity, ___domain spacing and tip bias.

Computing approaches in the optical ___domain would allow for ultra-fast signaling and ultra-high bandwidth capabilities. Here, Feldmann et al. demonstrate a photonic abacus, which provides multistate compute-and store operation by integrating phase-change materials with nanophotonic chips.

Solving optimization problems efficiently is a critical challenge, yet traditional physical minimizers that map the problem to a spin Hamiltonian suffer from limitations in their spin dynamics. We overcome this issue by introducing the Vector Ising Spin Annealer, which operates in a higher-dimensional space and demonstrates superior performance

Memristors hold promise for massively-parallel computing at low power. Aguirre et al. provide a comprehensive protocol of the materials and methods for designing memristive artificial neural networks with the detailed working principles of each building block and the tools for performance evaluation.

Molecular core levels are localized around a single atomic site, but for indistinguishable atoms, photoionised core-holes can either be seen as localized or delocalized. Using a prototypical symmetric system, CS₂, Guillemin et al. show that these states can be disentangled by fragmentation dynamics.

In wildlife tagging, stress from capture and handling can alter post- release behavior and potentially study interpretations. This study of 42 mammal species shows that these effects diminish within 4–7 days, and quicker for animals in high human activity areas indicating adaptation to disturbance.

A quantum many-body system’s equilibrium behaviour is described by its partition function, which is hard to compute. Now it has been shown that the easier task of finding an approximation could define a distinct class of computational problems.

The active zone is a brain signaling hub critical for synaptic information transfer and the encoding of behaviors. The authors identify Blobby as an assembly factor required for proper active zone nanoscale protein architecture and memory formation.

The emergence of relaxation in unitarily evolving systems can be seen as a paradox, but not once the distinction between local and global dynamics is considered. Here, the authors use photons in an integrated optical interferometer to show that, for a system evolving unitarily on a global level, single-mode measurements converge to those of a thermal state.

Simulating ultrafast quantum dissipation in molecular excited states is a strongly demanding computational task. Here, the authors combine tensor network simulation, entanglement renormalisation and machine learning to simulate linear vibronic models, and test the method by analysing singlet fission dynamics.

In presence of inter-system correlations, violations of the laws of thermodynamics become possible. Here, the authors develop a formalism redefining heat, work and thermodynamic laws in terms of quantum conditional entropy, which consistently generalize thermodynamics in correlated scenarios.

Hybrid quantum-classical techniques such as the quantum approximate optimisation algorithm can be useful for solving binary optimisation problems. The authors propose an improved initialisation strategy for the quantum part of the algorithm that favours quantum superposition while requiring few classical computational resources.

Planarians are model systems for stem cells and regeneration. This study provides new genome assemblies of the model species S. mediterranea and 3 relatives and uses comparative genomics of planarians to reveal that synteny is not an evolutionary constraint in flatworm genome evolution.

C9orf72 ALS/FTD polyGR and polyPR knock-in mice show cortical hyperexcitability and motor neuron loss accompanied by an increase in extracellular matrix proteins in the spinal cord that is conserved in patient iPS cell-derived neurons and is neuroprotective.

The application of resistive and phase-change memories in neuromorphic computation will require efficient methods to quantify device-to-device and switching variability. Here, the authors assess the impact of a broad range of device switching mechanisms using machine learning regression techniques.

A combination of gentle stimulated emission depletion microscopy imaging and deep-learning-based improvements in signal-to-noise ratio enables high-resolution reconstruction of neuronal architecture in living tissue.

Traditional systematic anti-seizure treatments alter brain-wide activity and often carry significant side effects. The authors engineered an inhibitory, acetylcholine receptor-based, chemogenetic tool to suppress targeted neurons, enabling control of chronic seizures in mice.

There is increasing effort to improve the signal sensitivity and explore the hyperpolarization dynamics. Here the authors demonstrate the parahydrogen spin transfer dynamics in compounds containing ¹⁵N using SABRE hyperpolarization technique with different strengths of the magnetic field.

Helium is an atom of great scientific interest, yet much debate exists surrounding the shape its molecules form. Here Voigtsberger et al. present experimental results imaging the wavefuction of ⁴He₃ and ³He₄He₂ trimer systems, which suggest that ⁴He₃ is a random cloud while ³He₄He₂is a quantum halo state.

In hepatocellular carcinoma driven by non-alcoholic steatohepatitis, aberrant T cell activation and impaired immune surveillance seem to make hepatocellular carcinoma less responsive to anti-PD1 or anti-PDL1 immunotherapy.

According to Noether’s theorem, every symmetry of a dynamical evolution implies a conservation law. Marvian and Spekkens show that this theorem is deficient for certain types of quantum dynamics, and they propose measures of the extent to which a quantum state breaks a symmetry.

The non-coding RNA RNU4-2, which is highly expressed in the developing human brain, is identified as a syndromic neurodevelopmental disorder gene, and, using RNA sequencing, 5′ splice-site use is shown to be systematically disrupted in individuals with RNU4-2 variants.

Here the authors show that ventrally derived oligodendrocytes (OLs) can myelinate areas usually populated by dorsally derived OLs but cannot functionally compensate, as animals populated only by ventrally derived OLs show locomotor and cognitive deficits.

The Hayabusa2 spacecraft found dark boulders with very high porosity (>70%, as high as cometary nuclei) at the bottom of small craters on Ryugu. Such boulders are probably the most pristine parts of the planetesimals that formed Ryugu’s parent body and might have been captured by Hayabusa2 sampling.