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The realization of high-performance flexible perovskite/crystalline-silicon tandem solar cells requires efficient photocarrier transport and mitigation of residual stress. Here, authors reveal the critical role of perovskite phase homogeneity, achieving flexible devices with efficiency of 29.88%.

There are currently no licensed vaccines to prevent Group A Streptococcus (GAS) infections. In this study, the authors evaluate the immune response and preclinical efficacy of a multicomponent mRNA lipid-nanoparticle vaccine against GAS.

O3-type sodium anion-redox cathodes show promise but are hard to synthesize due to unclear mechanisms. Here, authors elucidate the role of oxygen conditions, enabling O3-Na[Li_1/3Mn_2/3]O₂ synthesis and developing Ti-substituted with capacities >190 mAh·g^-1.

Rosmarinol quinone (RQ) induces β-catenin phase separation, suppressing Wnt/β-catenin signaling and tumorigenesis. Abroquinone (albumin–RQ complex) was developed for targeted delivery and improved biosafety.

Acetylation is a posttranscriptional modification widely distributed across RNA types. Here, the authors uncover the role of tRNA ac⁴C12 for translational efficiency and tRNA quality control in both normal and heat stress conditions in mammalian cells.

Embryonal tumour with multilayered rosettes (ETMR) is a rare and aggressive paediatric brain tumour. Here, the authors analyse intratumour heterogeneity and the tumour microenvironment in ETMR using single-cell and spatial transcriptomics, in vitro cultures, and a 3D forebrain organoid model, finding important aspects – such as the communication with pericytes – for ETMR development and response to therapy.

Ionic or molecular transport in conventional polymeric membranes often suffers from a trade-off between permeability and selectivity. The authors report on an interfacial polymer cross-linking strategy to produce a robust, permeable and selective 3-µm-thick ultrathin polymeric membrane containing quasi-ordered reticular cross-linking structures.

The function and regulatory mechanism of mRNA acetylation modification in cancer progression remains largely unknown. Here the authors identify that targeting tumor N4-acetylcytidine (ac4C) RNA acetyltransferase NAT10 improves anti-tumor response via MYC/CDK2/DNMT1/dsRNA/type I IFN pathway, and show the synergic anti-tumor effect of NAT10 inhibition with aPD-1.

Hypercompact type V CRISPR-Cas12n nucleases target DNA sequences containing rare A-rich PAMs. Here, authors reveal the cryo-EM structure of RdCas12n, detailing its RNA-guided DNA targeting and evolutionary origins, and engineer it for effective genome editing in human cells.

Gastric Squamous Cell Carcinoma (GSCC) is a rare subtype of gastric cancer with unknown etiology. Here, the authors identify frequent mutations in epigenetic regulation genes including EZH2 in twenty GSCC patient samples, and demonstrate that EZH2 loss, along with TP53 and PTEN loss, leads to GSCC in mouse models.

CRISPR base editors enable precise DNA changes but often cause off-target edits. Here, authors engineer two Sdd7 variants that minimize bystander and off-target mutations and show enhanced precision when delivered as ribonucleoproteins via engineered virus-like particles.

Hepatitis B virus (HBV) infection is associated with hepatitis and hepatocellular carcinoma (HCC). Here, the authors show that HBV promotes HCC formation only in response to environmental carcinogens, involving increased IL-33 signaling and regulatory T cells.

Brugada syndrome is a rare heart condition that results in abnormal cardiac electrophysiology. In this Primer, Narasimhan and colleagues discuss the epidemiology, mechanisms, diagnosis and management of Brugada syndrome, and outline how the syndrome affects patient quality of life.

Using pancreatic organoids and genetic mouse models, Antonucci et al. show that cellular stress activates an NRF2–EZH2 epigenetic axis leading to metabolic reprogramming and subsequent malignant transformation of KRAS-mutant benign lesions.

Song et al. developed a computational tool to profile binding pairs between tumor-derived antigens and antibodies from high-throughput B cell receptor sequencing data, predicting response to immune-checkpoint inhibitor therapy and risk of adverse events.

Arginine addiction induced by argininosuccinate synthase (ASSN1) deficiency has been exploited to treat ASS1-deficient cancers. Here, the authors show an alternative therapeutic approach where ASS1 activity is increased by the pesticide spinosyn A and is shown to inhibit breast cancer cell proliferation.

Using two cohorts, Liu, Ge, Xiao, Lu and colleagues perform plasma metabolomics and lipidomics, linking reduced sarcosine to sarcopenia diagnosis. In mice, they demonstrate that sarcosine enhances muscle repair, boosts adipose thermogenesis and preserves muscle mass via macrophage modulation.

Assumptions of technological and social adaptations to mitigate environmental impacts may be overstating potential gains in the face of population growth, according to this analysis of Israeli national data.

Xu et al. establish the importance of H2A.Z in mouse oocyte development. H2A.Z is incorporated into chromatin at promoters and putative enhancers, and its presence promotes histone acetylation in fully grown oocytes.

Here, the authors show that mechanical loading promotes subchondral bone osteocytes to secrete extracellular vesicles containing miR-23b-3p, which accelerates osteoarthritis progression by inhibiting mitophagy and disrupting cartilage metabolism.

Self-assembled monolayers targeting wide-bandgap perovskite solar cells are essential to reduce the open-circuit voltage loss. Here, the authors report the stepwise tuning of interfacial energy level through inductive effect, achieving perovskite/TOPCon tandem solar cells with efficiency over 31%.

Bessel-droplet two-photon fluorescence microscopy offers high-contrast and high-resolution volumetric imaging in vivo and can be used for high-throughput mapping of functional synaptic organization in the mouse brain.

Here the authors reveal via whole genome sequencing of an East Asian AD cohort a common variant locus (APCDD1), rare noncoding variants in excitatory neurons, and short tandem repeat expansions, suggesting a cumulative effects model for Alzheimer’s risk.

TNF inhibitors show clinical benefits for Behçet’s disease (BD), but the underlying molecular insights are still unclear. Here the authors use both patient samples and mouse genetic models to show that TNF inhibitors may target a metabolite/TRPM2/calcium signaling positive feedback loop of inflammation amplification for dampening vasculitis in BD.

CO₂ electroreduction is promoted by alkali cations in the electrolyte, but the precise mechanism by which this occurs is not clear. Now in situ infrared spectroscopy and ab initio molecular dynamics are combined to elucidate the specific role of alkali cations and their trends.

GlyT1 critically regulates excitatory neurotransmission and has thus emerged as a therapeutic target for schizophrenia. This study delineates the binding sites of the clinically trialed drugs iclepertin and sarcosine and elucidates how cholesterol modulates GlyT1 activity.

There is interest in methods to extend products shelf-life to reduce food waste. Here, the authors report on an amyloid-like protein coating that extends fruit shelf-life 2-5 times by blocking microbes and moisture loss, preserving nutrients, cutting waste and reducing the need for cold chain storage and transport.

Tailored non-aqueous electrolyte solutions are formulated using data obtained from extensive analytical measurements and analyses. These optimized electrolytes improve the cycling performance of single-layer stack lithium metal pouch cells, particularly in lean electrolyte conditions.

An implantable hydrogel-based phononic crystal that deforms with the surrounding tissues modifying the ultrasonic bandgap allows continuous and wireless monitoring of internal tissue strains.

This study uses genetic crossing to identify the genes underlying the differences in virulence between two Cryptosporidium isolates. Candidate genes are validated using genetic editing, revealing that the small granule protein SKSR1 is a key virulence factor in Cryptosporidium.

Analyses of whole-genome sequencing data in children and validation in mouse models show that offspring born from blastocyst-stage embryo transfer have shorter leukocyte telomere lengths.

A common but untested expectation is that nutrient enrichment causes biotic homogenization. However, a globally standardized nutrient addition experiment in grasslands shows proportionally similar species loss across scales and no biotic homogenization after up to 14 years of treatment.

Missing modality challenges longitudinal omics studies. Here, the authors introduce LEOPARD, a pioneering neural network that uses style transfer to re-entangle omics data, enabling robust imputation and unlocking fresh insights into predictive healthcare and biological temporal dynamics.

Improving oxygen evolution in acidic water electrolysis is vital for advancing clean hydrogen production. Here, the authors report that doping ruthenium oxide with selenium enhances efficiency and durability by tuning orbital band gaps, improving electron flow, and stabilizing oxygen vacancies.

A miniaturized and low-power-consumption system is designed to allow the accurate sensing and wireless transmission of internal temperature and strain signals inside lithium-ion batteries with negligible influence on their performance, improving their safety.

ERα^vlVMH neurons mediate the inhibitory role of 17β-oestradiol on prolactin production, and this inhibition is lifted in lactating mice to promote lactation-associated metabolic adaptations.

Salmonella is a major cause of foodborne disease worldwide. Authors created a Salmonella database and present a genetic atlas of antimicrobial resistance, identifying some socioeconomic and environmental drivers for the rise of resistance globally.

Plant-diversity effects on particulate and mineral-associated organic matter in soil remain underexplored. The authors propose that elucidating the mechanisms underlying these effects can help explain inconsistencies in plant-diversity–soil-carbon relationships across studies and better predict consequences of biodiversity loss/gain for soil carbon stocks.

Double-stranded RNA (dsRNA) is key in immunity and cellular regulation. Here, using the PISA workflow, the authors find 218 proteins with altered solubility upon dsRNA binding. ZNF385A knockout activates interferon-β transcription and increases endogenous dsRNA levels, enhancing the bioactivity of 5-Aza-2’-deoxycytidine and NK cell-mediated cytotoxicity.