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The realization of high-performance flexible perovskite/crystalline-silicon tandem solar cells requires efficient photocarrier transport and mitigation of residual stress. Here, authors reveal the critical role of perovskite phase homogeneity, achieving flexible devices with efficiency of 29.88%.

Acetylation is a posttranscriptional modification widely distributed across RNA types. Here, the authors uncover the role of tRNA ac⁴C12 for translational efficiency and tRNA quality control in both normal and heat stress conditions in mammalian cells.

Here, the authors show that mechanical loading promotes subchondral bone osteocytes to secrete extracellular vesicles containing miR-23b-3p, which accelerates osteoarthritis progression by inhibiting mitophagy and disrupting cartilage metabolism.

Prostate cancers (PCa) are characterized by an immunosuppressive tumor microenvironment. Here the authors identify a subset of iron-loaded cancer-associated fibroblasts secreting myeloid cell-associated proteins and driving immunosuppression in PCa.

Zhu and colleagues show that a subpopulation of spleen-derived fibroblasts secrete Gremlin 1, which suppresses chronic myeloid leukemia progression by inducing leukemia stem cell apoptosis through the BMP signaling pathway.

Missing modality challenges longitudinal omics studies. Here, the authors introduce LEOPARD, a pioneering neural network that uses style transfer to re-entangle omics data, enabling robust imputation and unlocking fresh insights into predictive healthcare and biological temporal dynamics.

Atomic level engineering of graphene-based materials is highly demanded for the customized structures and properties. Here, the authors show heteroatom dopant-specific unzipping of carbon nanotubes as a reliable and controllable route to customized 'intact crystalline' graphene-based nanostructures.

Analyses of whole-genome sequencing data in children and validation in mouse models show that offspring born from blastocyst-stage embryo transfer have shorter leukocyte telomere lengths.

The immune regulatory mechanism for metabolic dysfunction-associated steatohepatitis (MASH) remains elusive. Here, the authors identify a c-kit⁺ cDC1 subset, which can be depleted by Desulfovibrio_sp.-induced H₂S via autophagic cell death and contributing to uncontrolled inflammation for MASH progression.

This study describes sets of plasma proteins linked to AIDS- and noncommunicable disease-related deaths in people with HIV, revealing unique proteomic patterns that could improve the prediction of mortality and inform more targeted prevention and treatment.

By inducible and constitutive overexpressing ClpD-GFP to result in the accumulation of precursor proteins, this study presents comprehensive mechanistic insights in cellular responses to chloroplast precursor protein overaccumulation stress (cPOS).

Oligodendrocyte precursor cells (OPCs) play a multifaceted role in the brain. Here, the authors show that OPCs regulate neuronal metabolism by forming contacts with neuronal somata, facilitating lysosomal release from neurons.

Lung tissue-resident memory T cells play critical roles in the response to and protection to subsequent re-exposure and infection with influenza viruses. Here the authors explore vaccine induced lung resident memory T cells and their role in protection to heterosubtypic influenza infection in mice and ferrets.

The exact role FoxO3 in the regulation of cardiac regeneration remains unclear. Here, the authors show that FoxO3 negatively controls cardiomyocyte proliferation and heart regeneration in postnatal mice at least in part by promoting Sfrp2 expression.

Iron metabolism has been shown to play an important role in the development and function of the immune system, but its role in ILC3s is unclear. Here the authors show that CD71-mediated iron metabolism controls ILC3 proliferation and the host response to Citrobacter rodentium infection and CD71 expression is regulated by Ahr signaling.

The incidence of rheumatoid arthritis (RA) and accumulation of circulating free (cf) DNA increase with age but it is unknown whether DNA fragments cause joint inflammation. Here authors show that cf DNA levels are higher in RA patients and that in a rat adjuvant-induced arthritis model, the exonuclease TREX1 suppresses synovial inflammation via promoting the degradation of cf DNA and inhibiting a senescence-like cellular state.

The ASAP4 family of genetically encoded voltage indicators allows recording of action potentials and subthreshold activity with either one- or two-photon microscopy over extended periods of time.

The mechanisms that regulate the tissue-specific localization and functions of innate lymphoid cells are poorly understood. Xiong and colleagues find that CCR10⁺ innate lymphoid cells are selectively programmed in skin-draining lymph nodes for cutaneous homeostatic regulation.

Ageing is associated with clonal hematopoiesis of indeterminate potential (CHIP), which is linked to increased risks of hematological malignancies. Here the authors uncover an epigenetic mechanism through which mutant p53 drives clonal hematopoiesis through interaction with EZH2.

Turing-structured topology electrocatalysts are reported to control the reorientation of interfacial water through the tuning of surface oxophilicity. The optimal Turing catalyst achieves a formate Faradaic efficiency of 92.0% at 1,000 mA cm⁻².

A deeper knowledge of the immune cell profile within the brain cancer tumor microenvironment (TM) could identify targets to improve immunotherapy efficacy. Here, in glioblastoma, the authors find haematopoietic stem and progenitor cells in the TM, which are associated with poor prognosis and increased immunosuppression.

A genome-wide association meta-analysis study of blood lipid levels in roughly 1.6 million individuals demonstrates the gain of power attained when diverse ancestries are included to improve fine-mapping and polygenic score generation, with gains in locus discovery related to sample size.

Vertebral osteoblasts in mouse and human are formed from a precursor skeletal stem cell population that is distinct from long bone skeletal stem cells in function, ___location and transcriptional programme.

The apelin receptor (APJR) is a drug target for cardiovascular and metabolic health. Here, authors reveal how ligand binding, receptor dimerization, and G protein coupling cooperate to regulate APJR signaling pathway, providing insight for drug discovery.

A large genome-wide association study of more than 5 million individuals reveals that 12,111 single-nucleotide polymorphisms account for nearly all the heritability of height attributable to common genetic variants.

Development of efficient upconversion (UC) phosphors that emit under irradiation in the NIR II region is challenging - most UC materials rely on the presence of sensitizers absorbing at shorter wavelengths. Here, authors synthesize Er³⁺ doped ternary sulfides phosphors with visible UC efficiency up to 2.6% and long emission lifetimes under 1532 nm irradiation, via an excited state absorption mechanism.

This study profiles the spatial transcriptomic landscape of mouse brain coronal sections across three age groups and both sexes. Here, authors show a strong female-biased pro-inflammatory gene signature in white matter fiber tracts.

The intestine is an important immunological organ in embryonic life, preparing the infant for the microbial colonization following birth. Here authors show that between gestational weeks 14 and 22, the human foetal intestine is first populated by myeloid and innate lymphoid cells, followed by the development of lymphoid cells and a wider range of proliferation-capable immune cell types.

A room-temperature approach to monolithic three-dimensional thin-film integration can be used to stack ten layers of n-channel indium oxide transistors on silicon/silicon dioxide substrates, while incorporating a range of architectures.

ASXL2 mutations are mostly found in a subset of leukemia patients with certain genetic aberrations; however the role of this protein in normal hematopoiesis and related malignancies is still unclear. Here the authors use a knock-out mouse model to uncover the role of Asxl2in hematopoiesis and leukemogenesis.

Nanomedicine has promise for treatment of cancer, but achieving targeting and efficacy is challenging. Here, the authors report the development of gold-based aggregation-induced emission materials that demonstrate tumour cell specific targeting and lead to cell death.

Targeted black phosphorus nanosheet-based therapeutics that efficiently deliver resolvin D1 to lesional macrophages for the treatment of atherosclerosis by reducing oxidative stress and resolving inflammation have been discussed.

Ni et al. report that Snail1 promotes mammary tumour initiation and maintenance independently of its role in EMT. They show that Snail1 forms a complex with HDAC1 and p53 that results in p53 inactivation and degradation, permitting tumour formation.

The m6A binding protein YTHDF1 is frequently upregulated in cancer. Here the authors report that USP5 deubiquitinates and stabilizes YTHDF1, associated with cancer growth and immune evasion, and that targeting USP5 potentiates response to anti-PD-L1 in preclinical models.

Hashimoto’s thyroiditis (HT) is the main cause of hypothyroidism. Here the authors develop a deep learning model for diagnosis of HT on a large multi-site dataset including image and video data.

UDA-seq incorporates a post-indexing step to enhance the throughput of droplet-based single-cell multimodal sequencing, enabling efficient large-scale single-cell analysis.

In this study, Qian et al. identify a crosstalk between branched-chain amino acid metabolism and cell growth and motility through RhoC. Their work shows how enhanced BCAT1 activity, as identified by a mutation enriched in gastric cancer, leads to increased production of a metabolite that activates RhoC signaling.

Fibroblast growth factors are involved in systemic glucose homeostasis and of interest for developing therapies for type 2 diabetes and associated metabolic diseases. Here the authors identify paracrine FGF4 as an anti-hyperglycemic FGF, which targets skeletal muscle to upregulate the glucose transporter GLUT4 cell surface abundance.

Magnetic semiconductors provide control of spin states in addition to charge states realized in conventional semiconductors, yet currently limited to weak magnetism at low temperature. Liuet al. introduce oxygen into a ferromagnetic metallic glass, resulting in a Curie temperature above 600 K.