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We present a DNA self-assembly based molecular data writing strategy to enable parallel movable-type printing for scalable DNA storage.

Conventional silicon-based transistors, which sit at the heart of every computer, are fast approaching the limit of miniaturisation. Here, Meng et al demonstrate a field-effect transistor composed of a single rutheniumdiarylethene molecule with large on/off ratio.

Determining the causal variants at GWAS loci is crucial for understanding genetic disease mechanisms. Here, the authors apply MPRA to perform non-small cell lung cancer (NSCLC) variant-to-function mapping at scale and propose distinct genetic architectures underlying NSCLC susceptibility.

Despite lung adenocarcinoma having a high global mortality, the genetic mutations present in Asian patients are uncharacterized. Here the authors use genomic and transcriptomic analysis to identify thirteen significantly affected genes, including RHPN2, GLI3, MRC2, TP53 and IQGAP3.

Understanding if lasting immune responses can be induced by SARS-CoV-2 infection is important for controlling the COVID-19 pandemic. Here, the authors show, in a cohort of 25 patients, that IgG and T cell responses, as well as neutralising antibody, are still detectable against various SARS-CoV-2 proteins 3 months post-symptom onset, while IgM levels largely wane at this time.

FGF signaling through ERK is known to promote the differentiation of embryonic stem cells (ES cells). Here, the authors demonstrate that the lncRNA Trincr1 binds and represses TRIM71 in ES cells, leading to downregulation of SHCBP1 protein, the reduction of FGF/ERK signaling and the promotion of self-renewal.

Planthoppers are among the most destructive pests on rice. This study identified that a leucine-rich repeat protein OsLRR2 negatively regulates defence responses. Knockout of the encoding gene OsLRR2 enhances rice herbivore resistance and yield, which holds the potential to produce high-yielding rice varieties that are resistant to devastating pest insects.

Developed on cytology images of hydrothorax and ascites from 57,220 cases at four hospitals, a deep-learning model shows high accuracy in tumor origin prediction and presents prognostic value when patient treatment is consistent with the cancer origin predicted by the model.

Here, the authors report immunogenicity and safety of AR-MPXV5, a penta-component mRNA vaccine, in naive and simian immunodeficiency virus infected nonhuman primates (NHPs), and demonstrate protection in naïve male NHPs after immunization with two doses of AR-MPXV5.

The high non-radiative energy loss is a bottleneck issue for efficient organic solar cells. Here, the authors regulate the charge transfer state disorder and rate of back charge transfer through a ternary system, achieving low non-radiative energy loss of 0.183 eV and device efficiency of 20.25%.

GPR174 is a lysophosphatidylserine (LysoPS) activated GPCR. Here, the authors report the cryo-EM structure of LysoPS-bound human GPR174 in complex with G_s protein. The study reveals how GPR174 recognizes the lipid ligand and engages G_s in a distinct binding mode.

Zhu, He, Zhang et al. conduct a cross-sectional study examining the relationship between temperature and fluid intake in Chinese children. Findings reveal a 24 mL daily intake increase per 1 °C temperature rise and projections under climate change scenarios predict substantially higher hydration needs by 2099.

Hyaluronan is a naturally occurring linear polysaccharide that together with collagens, enzymes, and glycoproteins forms the extracellular matrix. Here the authors show that adipose tissue overproduction of Hyaluronan reduces fat accumulation in mice fed high-fat diet and improves systemic glucose homeostasis.

Here the authors show mutation of the BAF chromatin remodeler subunit ARID1A results in an ARID1B-dependent upregulation of HERVH, an ERV required for the pluripotency regulatory network. These HERVH RNAs can partition into BRD4 foci, affecting BRD4-dependent transcription. Suppression of HERVH in colorectal cancer cells and patient-derived organoids impairs tumor growth.

Different gene mutations have been reported as drivers for myeloproliferative neoplasms (MPN). Here, the authors show that Gadd45g insufficiency induces MPN in mouse models and associates with MPN in patients.

Spur-type of growth is preferred for apple production. Here, the authors employ the trio-based phasing approach to assemble a fully phased Fuji genome and reveal the association of a 167-bp deletion in the promoter region of the MdTCP11 gene with the spur-type varieties.

Developing robust catalysts for proton-exchange membrane water electrolyzers is essential for industrial applications. Here, the authors report a Pb-RuO₂ catalyst that uses large-sized Pb to reduce the reactivity of lattice oxygen, enhancing stability and allowing it to operate for over 1100 h.

PAQR4 regulates cellular ceramide synthesis and accumulation to mediate adipose tissue function, glucose homoeostasis and, thus, systemic metabolic health.

Continuous directed evolution of base editors (BEs) has been successful in bacteria cells, but not yet in mammalian cells. Here, the authors report a Continuous Directed Evolution system in Mammalian cells (CDEM) enabling the BE evolution in a full-length manner with Cas9 nickase.

A cell-cycle checkpoint triggers the extrusion of both nematode and mammalian cells experiencing replication stress.

Activated GBP5 binds to STAT1, facilitating its nuclear translocation, which induces STAT1 transcription and cytokine production, ultimately promoting innate lymphoid cell expansion and exacerbating inflammation.

Experiments have shown that fast ions generated in fusion plasmas improve confinement by mitigating plasma turbulence. This Review explores possible physical mechanisms to explain these experimental observations.

The instability of the host structure of cathode materials and sluggish aluminium ion diffusion are the major challenges facing the Al-ion battery. Here the authors show Al_xMnO₂·nH₂O as a cathode that allows for reversible Al³⁺ (de)intercalation in an aqueous electrolyte and impressive electrochemical performance for a battery device.

Pickering emulsions are particle-stabilized droplets suspended in an immiscible liquid, and the study of individual droplet coalescence has yielded many interesting findings. Here, Wu et al. move towards larger droplet numbers to investigate the influence of population on coalescence.

Through gene knockout experiments, Sicinski and colleagues reveal a role for cyclin C as a haploinsufficient tumour suppressor in T-cell acute lymphoblastic leukaemia, acting through phosphorylation of intracellular Notch1, mediating its degradation.

Zhou et al. report a novel 5-HT circuit from the dorsal raphe nucleus to somatostatin-expressing neurons in the central nucleus of the amygdala that partially mediates depressive-like behavior in a mouse model of chronic pain.

Liu and colleagues find differential effects of microglial apoE isoforms on brain function and microglial responses. ApoE3 enhances microglial responses, promoting brain function and reducing amyloid deposition and associated neurotoxicity, while the Alzheimer’s disease-associated apoE4 results in lipid droplet accumulation and impaired microglial responses, which are critical for limiting the development of amyloid pathology.

The reason for a re-emergence of scarlet fever in China remains unclear. Here the authors show that the number of scarlet fever cases surged in 2011 peaking in 2018, this correlates with an increase in NO₂ and O₃ but does not necessarily imply causation.

Deep vein thrombosis after trauma (pt-DVT) patients undergo metabolic changes but a comprehensive characterization in humans is lacking. Here the authors integrate metabolome and proteome to reveal pt-DVT-related metabolic alterations and their function, and reveal potential biomarkers.

Cryptochrome 2 (CRY2) from A. thaliana can be used to control light-dependent protein homo-oligomerization, but the molecular mechanism of CRY2 clustering is not known, limiting its application. Here the authors identify determinants of CRY2 clustering and engineer fusion partners to modulate clustering efficiency.

Isopropenyl ethers (IPPEs) are essential intermediates for obtaining ketal-based prodrugs and biomaterials, but traditional approaches for their synthesis are limited by poor functional group compatibility and harsh reaction conditions. Here, the authors report an organocatalytic transisopropenylation approach for IPPE synthesis in mild reaction conditions and with wide range of substrates, and use it to prepare acid-sensitive ketal-linked prodrugs and biomaterials.

Liu, Xie and colleagues profile putative cis-regulatory elements in mouse oocytes and pre-implantation embryos. They further validate putative enhancers in oocytes and identify the transcription factors TCF3 and TCF12 as key regulators of folliculogenesis.

The mediators of bone-fat axis remain largely unknown. Here, the authors show SHN3 gene-deficiency in bone can protect mouse models from weight gain driven by diet-induced obesity through secreting a bone-derived cytokine, C-fragment of SLIT2, which could stimulate adipocyte browning.

Runx2 is essential for tuning the generation of bone from skeletal stem cells (SSCs). Here, the authors demonstrate that the CK2/HAUSP pathway stabilizes RUNX2 protein thereby regulating the commitment of SSCs to osteoprogenitors as well as their subsequent maturation, and that inhibition of this pathway can block heterotopic ossification.

In the Drosophila midgut, multipotent intestinal stem cells (ISCs) produce daughters that differentiate into either enterocytes or enteroendocrine cells. It is shown that canonical Wnt signalling pathway controls ISC self-renewal, and that Notch acts downstream of the Wg pathway and a hierarchy of Wg/Notch signalling pathway controls the balance between self-renewal and differentiation of ISCs.

Mouse models expressing liver apoE in the absence of brain apoE reveal detrimental effects of peripheral apoE4 associated with Alzheimer’s risk on cognition and amyloid pathology through compromising vascular integrity and function.

DNA hydroxymethylation (5hmC) is typically altered in age-related diseases. Here, the authors show that 5hmC accumulates in gene bodies, partially due to prolonged quiescence, and restricts the magnitude of transcriptional changes with age.