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The function and regulatory mechanism of mRNA acetylation modification in cancer progression remains largely unknown. Here the authors identify that targeting tumor N4-acetylcytidine (ac4C) RNA acetyltransferase NAT10 improves anti-tumor response via MYC/CDK2/DNMT1/dsRNA/type I IFN pathway, and show the synergic anti-tumor effect of NAT10 inhibition with aPD-1.

Improving oxygen evolution in acidic water electrolysis is vital for advancing clean hydrogen production. Here, the authors report that doping ruthenium oxide with selenium enhances efficiency and durability by tuning orbital band gaps, improving electron flow, and stabilizing oxygen vacancies.

Glutamatergic neurons in the parvocellular part of the medial vestibular nucleus mediate motion-induced hypothermia and can be targeted to prevent diet-induced obesity.

Phylogenetic origin of the Y haplome present in allopolyploid Triticeae species is unclear. Here, the authors report the genome assembly of allohexaploid Elymus nutans, reveal the all likely combinations of St, Y, and H haplomes during the allopolyploid origins, and identify gene responsible for UV-B radiation adaptation.

The incidence of rheumatoid arthritis (RA) and accumulation of circulating free (cf) DNA increase with age but it is unknown whether DNA fragments cause joint inflammation. Here authors show that cf DNA levels are higher in RA patients and that in a rat adjuvant-induced arthritis model, the exonuclease TREX1 suppresses synovial inflammation via promoting the degradation of cf DNA and inhibiting a senescence-like cellular state.

The authors identify a neural population in the basal forebrain of mice that is key for maintaining energy balance by facilitating homoeostatic feeding while suppressing hedonic overeating.

The authors show that stimulus strength-dependent effects of DA on 5-HT^DRN neurons bidirectionally regulate feeding in mice. DRD1-mediated activation of 5-HT^DRN neurons contributes to activity-based anorexia, and this can be prevented by blocking DRD1.

Here, the authors report immunogenicity and safety of AR-MPXV5, a penta-component mRNA vaccine, in naive and simian immunodeficiency virus infected nonhuman primates (NHPs), and demonstrate protection in naïve male NHPs after immunization with two doses of AR-MPXV5.

Glucose-sensing neurons are found in the ventromedial hypothalamic nucleus (VMH). Here the authors identify the role of estrogen receptor-α expressing neurons in the ventrolateral subdivision of the VMH in sensing hypoglycemia.

2D materials can be doped with magnetic atoms in order to boost their potential applications in spintronics. Here, the authors fabricate Fe-doped SnS₂ monolayers and show that Fe_0.021Sn_0.979S₂ exhibits ferromagnetic behaviour with perpendicular anisotropy at 2 K, and a Curie temperature of 31 K.

Asparagales is the largest monocot order. Here, the authors produce the phylogeny of Asparagales with transcriptomic data from 455 species and investigate the evolution of genes involved with allium flavor biosynthesis.

Spur-type of growth is preferred for apple production. Here, the authors employ the trio-based phasing approach to assemble a fully phased Fuji genome and reveal the association of a 167-bp deletion in the promoter region of the MdTCP11 gene with the spur-type varieties.

Driven by dynamic covalent and coordinate bonding, hierarchical components are formed in situ and assembled in an ordered manner, yielding highly crystalline supramolecular nanotubular frameworks and tubular covalent organic frameworks.

Perovskite light-emitting diodes show promising color tunability and device performance but suffer from emission color shift at higher driving voltages. Here Xing et al. report color stable blue light-emitting diodes by drastically increasing the phase purity of the quasi-2D perovskite thin films.

The strong scattering of biological tissue causes challenges when monitoring temperature changes at the microscale. Here, the authors propose a nanothermometer based on lanthanide luminescence, enabling minimally invasive imaging of the cerebrovascular system of mice at nearly 200 μm resolution.

Isopropenyl ethers (IPPEs) are essential intermediates for obtaining ketal-based prodrugs and biomaterials, but traditional approaches for their synthesis are limited by poor functional group compatibility and harsh reaction conditions. Here, the authors report an organocatalytic transisopropenylation approach for IPPE synthesis in mild reaction conditions and with wide range of substrates, and use it to prepare acid-sensitive ketal-linked prodrugs and biomaterials.

A large genome-wide association study of more than 5 million individuals reveals that 12,111 single-nucleotide polymorphisms account for nearly all the heritability of height attributable to common genetic variants.

A genome-wide association meta-analysis study of blood lipid levels in roughly 1.6 million individuals demonstrates the gain of power attained when diverse ancestries are included to improve fine-mapping and polygenic score generation, with gains in locus discovery related to sample size.

An energy-efficient physical reservoir is crucial for reservoir computing (RC). Here the authors demonstrate an all-electric skyrmion-enhanced strain-mediated physical RC system and achieve a benchmark chaotic time series prediction.

The mechanism underlying hepatocytes apoptosis, a key process in the progression of nonalcoholic steatohepatitis, remains unclear. Here, the authors identify UGDH and its catalytic product UDP-glucuronate as suppressors of NASH-associated liver damage by inhibiting RIPK1- dependent hepatocyte apoptosis.

Optimisation of nucleic acid probes and blocker strands can be laborious. Here the authors construct a theoretical model of competitive DNA hybridisation to design DNA probes for optimisation-free mutation detection.

Deletion of cas3(type I-Fa) significantly reduced the biofilm formation, virulence and pathogenicity to mice. Mechanism analysis proved that this maybe because cas3 can lead to the down-regulation of biofilm formation related factors and ompA.

The Drosophila R8 photoreceptor separates signals for image perception and circadian photoentrainment by co-releasing histamine and acetylcholine, and this segregation is further established in the postsynaptic circuitry in the medulla.

Model systems to study SARS-CoV-2 infection are required to better understand the immune response. Here the authors use a lung and macrophage co-culture system by differentiation of human pluripotent stem cells to better understand the phenotype and gene expression changes in host lung cells and macrophages after SARS-CoV-2 infection in vitro.

Human case studies suggest that Zika virus can be transmitted independently of mosquitoes and sexual contact. Here, the authors show intranasal Zika infection in different animal models and show that contact transmission of Zika virus occurs in guinea pigs.

Dongxin Lin, Philip Taylor, Li-Dong Wang and colleagues have now pooled three genome-wide association analyses of esophageal squamous cell carcinoma, finding two new risk loci at genome-wide significance and an HLA class II locus of significance in high-risk populations. They reanalyze the strength of evidence for previously published risk loci.

The role of focal amplifications and extrachromosomal DNA (ecDNA) is unknown in gastric cardia adenocarcinoma (GCA). Here, the authors identify frequent focal amplifications and ecDNAs in Chinese GCA patient samples, as well as the potential associations of these alterations with prognosis and dietary habits.

Multiple pathogenic viruses are identified in a large set of pangolins, which shows that trading pangolins for scales or flesh may increase the risk of emergence of viral infections.

Up-conversion photoluminescence in colloidal quantum dots is generally believed to be mediated by thermal activation from defect states. Here, the authors reveal that highly-efficient up-conversion photoluminescence instead is related to electron-phonon coupling.

Non-obstructive azoospermia affects 1% of men. Here, authors perform single-cell transcriptomic analysis of human testicular cells from healthy donors and non-obstructive azoospermia patients and find that inhibition of Wnt signaling promotes the maturation of Sertoli cells from patients.

Higher intake of dietary fiber and whole grains are associated with reduced risk of various diseases including some cancers. Here, the authors estimate reductions in liver cancer of 22% and 31% and chronic liver disease mortality of 56% and 63% associated with increased whole grain and dietary fiber intake, respectively.

Two-dimensional materials can present ferroelectricity by layer sliding, but electrical confirmation is lacking due to narrow bandgaps. Here, a single-crystal coordination polymer with large bandgap enabling direct electrical measurement of P–E hysteresis is shown to present sliding ferroelectricity.

Negative thermal expansion alloys possess an important role in regulating thermal expansion. Here, the authors report a giant uniaxial negative thermal expansion, mainly driven by high-frequency optical branches, in metallic FeZr₂ from 93 to 1078 K.

Nanosized ceria has conventionally been thought to have a cubic fluorite structure. Here, the authors use a combination of experiments and simulations to show that oxygen vacancies in ceria promote a charge-transfer induced phase transition from tetragonal to cubic.

Xue-Jun Zhang and colleagues report genome-wide association analyses identifying six new susceptibility loci in the Chinese population.