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Communications Biology (1)

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A culture method with berbamine, a plant alkaloid, enhances CAR-T cell efficacy through modulating cellular metabolism

When used in CAR-T cell processing, the plant alkaloid berbamine prolongs the survival of leukemic animals by boosting CAR-T cell viability, memory phenotype, and persistence by modulating cellular metabolism, including mitochondrial respiration.

Shin-ichiro Takayanagi
Sayaka Chuganji
Shin Kaneko
ResearchOpen Access04 Jun 2024
Communications Biology

Volume: 7, P: 1-14

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A culture method with berbamine, a plant alkaloid, enhances CAR-T cell efficacy through modulating cellular metabolism

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