Oxetane is a four-membered, oxygen-containing heterocyclic compound of importance in medicinal chemistry and drug development. Here, the authors report the discovery and subsequent protein engineering of a halohydrin dehalogenase, and develop a biocatalytic platform for enantioselective formation and ring-opening of oxetanes.
- Xia Hua
- Yuan-Fei Wang
- Nan-Wei Wan
