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Showing 1–50 of 72 results

Advanced filters: Author: Nayoung Kim Clear advanced filters

Single-cell transcriptomics reveal cellular diversity of aortic valve and the immunomodulation by PPARγ during hyperlipidemia

Identifying the mechanisms underlying the early inflammatory phase of aortic valve disease is crucial for disease prevention. Here the authors perform single-cell RNA sequencing to show the immunomodulatory role of PPARγ in valvular endothelial cells during hyperlipidemia.

Seung Hyun Lee
Nayoung Kim
Jae-Hoon Choi
ResearchOpen Access17 Sept 2022
Nature Communications

Volume: 13, P: 1-22
The effect of dialysis modality on annual mortality: A prospective cohort study

Yae Hyun Kim
Yeonjin Kim
Hyung Jung Oh
ResearchOpen Access18 Jun 2024
Scientific Reports

Volume: 14, P: 1-9
Prevalence and detection of low-allele-fraction variants in clinical cancer samples

High-throughput sequencing is used to identify somatic variants in cancer patients. Here, the authors perform panel-based profiling of 5095 clinical samples and demonstrate that many clinically-actionable variants have low variant allele fractions, requiring assays with high detection sensitivity.

Hyun-Tae Shin
Yoon-La Choi
Woong-Yang Park
ResearchOpen Access09 Nov 2017
Nature Communications

Volume: 8, P: 1-10
Single-cell RNA sequencing demonstrates the molecular and cellular reprogramming of metastatic lung adenocarcinoma

Understanding the mechanisms that lead to lung adenocarcinoma metastasis is important for identifying new therapeutics. Here, the authors document the changes in the transcriptome of human lung adenocarcinoma using single-cell sequencing and link cancer cell signatures to immune cell dynamics.

Nayoung Kim
Hong Kwan Kim
Hae-Ock Lee
ResearchOpen Access08 May 2020
Nature Communications

Volume: 11, P: 1-15
Lineage-dependent gene expression programs influence the immune landscape of colorectal cancer

Single-cell RNA sequencing of colorectal tumors highlights associations between lineage-related gene expression signatures and specific stromal and immune cell populations.

Hae-Ock Lee
Yourae Hong
Woong-Yang Park
Research25 May 2020
Nature Genetics

Volume: 52, P: 594-603
Pharmacogenomic landscape of patient-derived tumor cells informs precision oncology therapy

Analysis of genomic and transcriptomic data from 462 patient-derived tumor cell (PDC) samples across 14 cancer types, along with pharmacological responses to 60 agents, indicates that PDC-derived drug sensitivities might be predictive of clinical response to targeted therapies.

Jin-Ku Lee
Zhaoqi Liu
Do-Hyun Nam
Research27 Sept 2018
Nature Genetics

Volume: 50, P: 1399-1411
2′–5′ oligoadenylate synthetase‑like 1 (OASL1) protects against atherosclerosis by maintaining endothelial nitric oxide synthase mRNA stability

Maintaining optimal eNOS levels is important during cardiovascular events, although little is known regarding the mechanism of eNOS protection. Here, the authors show a regulatory role of endothelial OASL1 in maintaining eNOS mRNA stability and vascular biology under atheroprone conditions.

Tae Kyeong Kim
Sejin Jeon
Goo Taeg Oh
ResearchOpen Access04 Nov 2022
Nature Communications

Volume: 13, P: 1-19
Tandem-biocatalysis reactors constructed by topological evolution of CaCO₃ particles into hollow metal hydroxide spheres

Hollow inorganic spheres (HISs) hold potential in various technological areas including biocatalysis and biomedicine, but the harsh synthetic conditions have precluded the use of HISs in biological fields. Here, the authors report a biocompatible strategy for synthesizing metal hydroxide HISs that can function as tandem-biocatalytic reactors.

Sang Yeong Han
Nayoung Kim
Insung S. Choi
ResearchOpen Access26 Oct 2023
Nature Communications

Volume: 14, P: 1-8
Surface enhanced Raman scattering artificial nose for high dimensionality fingerprinting

Label-free surface-enhanced Raman spectroscopy is an emergent method for the detection and discrimination of biological analytes. Here, the authors describe SERS sensors with arrayed mildly-selective surface chemistries to give a fingerprint based on different interactions for analysing biological samples.

Nayoung Kim
Michael R. Thomas
Molly M. Stevens
ResearchOpen Access10 Jan 2020
Nature Communications

Volume: 11, P: 1-12
Generation of a genetically engineered porcine melanoma model featuring oncogenic control through conditional Cre recombination

Dongjin Oh
Nayoung Hong
Sang-Hwan Hyun
ResearchOpen Access10 Jan 2025
Scientific Reports

Volume: 15, P: 1-17
Structure and mechanism of activity-based inhibition of the EGF receptor by Mig6

Mig6 phosphorylation at two consecutive tyrosines induces rearrangements that lead to Mig6 sticking to and inhibiting the same EGFR that catalyzed its phosphorylation. This mechanism may serve as a basis for inhibition of oncogenic EGFR variants.

Eunyoung Park
Nayoung Kim
Michael J Eck
Research17 Aug 2015
Nature Structural & Molecular Biology

Volume: 22, P: 703-711
Nanozyme-catalysed CRISPR assay for preamplification-free detection of non-coding RNAs

The combination of catalytic platinum particles, nanozymes and a CRISPR-based reaction allows for the quantification of non-coding RNAs at the picomolar range. This assay, CrisprZyme, has a colorimetric readout and works at room temperature without preamplification.

Marta Broto
Michael M. Kaminski
Molly M. Stevens
Research04 Aug 2022
Nature Nanotechnology

Volume: 17, P: 1120-1126
Visibility challenges for Asian scientists

Nine researchers, editors and science communicators share their views about the barriers that Asian scientists encounter in publishing their work and becoming more visible on the international level.

Shravan Hanasoge
Noriaki Horiuchi
Jens Wilkinson
Reviews31 Mar 2020
Nature Reviews Physics

Volume: 2, P: 178-180
Changes in anti-Müllerian hormone values for ovarian reserve after minimally invasive benign ovarian cystectomy: comparison of the Da Vinci robotic systems (Xi and SP) and the laparoscopic system

Yunjeong Park
Ayoung Song
Yong Jin Kim
ResearchOpen Access20 Apr 2024
Scientific Reports

Volume: 14, P: 1-8
Jagged1 intracellular ___domain/SMAD3 complex transcriptionally regulates TWIST1 to drive glioma invasion

Jung Yun Kim
Nayoung Hong
Hyunggee Kim
ResearchOpen Access13 Dec 2023
Cell Death & Disease

Volume: 14, P: 1-13
The Helicobacter pylori Genome Project: insights into H. pylori population structure from analysis of a worldwide collection of complete genomes

The bacterium Helicobacter pylori, often found in the human stomach, can be classified into distinct subpopulations associated with the geographic origin of the host. Here, the authors provide insights into H. pylori population structure by collecting over 1,000 clinical strains from 50 countries and generating and analyzing high-quality bacterial genome sequences.

Kaisa Thorell
Zilia Y. Muñoz-Ramírez
Charles S. Rabkin
ResearchOpen Access11 Dec 2023
Nature Communications

Volume: 14, P: 1-16
Novel KCNQ4 variants in different functional domains confer genotype- and mechanism-based therapeutics in patients with nonsyndromic hearing loss

Sang-Yeon Lee
Hyun Been Choi
Byung Yoon Choi
ResearchOpen Access28 Jul 2021
Experimental & Molecular Medicine

Volume: 53, P: 1192-1204
Structure-mechanism-based engineering of chemical regulators targeting distinct pathological factors in Alzheimer’s disease

To advance our understanding of pathological features associated with Alzheimer’s disease (AD), chemical tools with distinct specificity towards AD targets would be valuable. Here the authors used a structure-mechanism-based design strategy to obtain small molecules as chemical regulators for distinct pathological factors linked to AD pathology.

Michael W. Beck
Jeffrey S. Derrick
Mi Hee Lim
ResearchOpen Access13 Oct 2016
Nature Communications

Volume: 7, P: 1-13
Overexpression and unique rearrangement of VH2 transcripts in immunoglobulin variable heavy chain genes in ankylosing spondylitis patients

Yeon Joo Kim
Nayoung Kim
Chang-Hoon Nam
ResearchOpen Access22 Feb 2010
Experimental & Molecular Medicine

Volume: 42, P: 319-326
Single-cell mapping of combinatorial target antigens for CAR switches using logic gates

CAR-T targets are identified using logic gates and single-cell expression data.

Joonha Kwon
Junho Kang
Jung Kyoon Choi
Research16 Feb 2023
Nature Biotechnology

Volume: 41, P: 1593-1605
Drosophila ubiquitin-specific peptidase 14 stabilizes the PERIOD protein by regulating a ubiquitin ligase SLIMB

USP14 regulates PERIOD (PER) protein stability post-translationally in Drosophila via interaction with SLIMB, a protein involved in PER degradation, and Lys1117 and Lys1118 are key ubiquitination sites critical for maintaining PER stability.

So Who Kang
Jung-Eun Park
Min-Ji Kang
ResearchOpen Access07 Feb 2025
Communications Biology

Volume: 8, P: 1-10
Assessment of adverse events related to anti-influenza neuraminidase inhibitors using the FDA adverse event reporting system and online patient reviews

Nayoung Han
Jung Mi Oh
In-Wha Kim
ResearchOpen Access20 Feb 2020
Scientific Reports

Volume: 10, P: 1-8
CXCR7 promotes migration and invasion in head and neck squamous cell carcinoma by upregulating TGF-β1/Smad2/3 signaling

Nayoung Kim
Hyewon Ryu
Hyo Jin Lee
ResearchOpen Access02 Dec 2019
Scientific Reports

Volume: 9, P: 1-11
Block of A1 astrocyte conversion by microglia is neuroprotective in models of Parkinson’s disease

Agonism of microglial glucagon-like peptide-1 receptor (GLP1R) using a brain-penetrant peptide prevents the generation of neurotoxic astrocytes and ameliorates disease progression in two rodent models of Parkinson’s disease.

Seung Pil Yun
Tae-In Kam
Han Seok Ko
Research11 Jun 2018
Nature Medicine

Volume: 24, P: 931-938
Cardiac glycosides display selective efficacy for STK11 mutant lung cancer

Nayoung Kim
Hwa Young Yim
Sukjoon Yoon
ResearchOpen Access19 Jul 2016
Scientific Reports

Volume: 6, P: 1-11
Molecular checkpoints controlling natural killer cell activation and their modulation for cancer immunotherapy

Hyung-Joon Kwon
Nayoung Kim
Hun Sik Kim
ReviewsOpen Access31 Mar 2017
Experimental & Molecular Medicine

Volume: 49, P: e311
Large excitons in light-dress

Giant exciton–polaritons come to the scene from a thin Cu₂O crystal sandwiched by a microcavity. Their anticipated strong interactions may facilitate the development of a promising Rydberg solid-state platform for quantum technologies.

HeeBong Yang
Na Young Kim
News & Views29 Jun 2022
Nature Materials

Volume: 21, P: 736-737
Single-cell RNA sequencing reveals myeloid and T cell co-stimulation mediated by IL-7 anti-cancer immunotherapy

Hye Hyeon Eum
Dasom Jeong
Hae-Ock Lee
ResearchOpen Access29 Feb 2024
British Journal of Cancer

Volume: 130, P: 1388-1401
Full etiologic spectrum of pediatric severe to profound hearing loss of consecutive 119 cases

Young Seok Kim
Yoonjoong Kim
Byung Yoon Choi
ResearchOpen Access19 Jul 2022
Scientific Reports

Volume: 12, P: 1-9
Where two quantum fluids meet

Josephson vortices are observed at the boundary between two exciton-polariton condensates, with lasers used to create the required local phase twist. The finding opens new opportunities for exploring fundamental physics and engineering novel quantum devices.

Taehyun Yoon
Na Young Kim
News & Views21 Jun 2019
Nature Photonics

Volume: 13, P: 441-442
Comprehensive genetic exploration of skeletal dysplasia using targeted exome sequencing

Jun-Seok Bae
Nayoung K. D. Kim
Tae-Joon Cho
Research24 Sept 2015
Genetics in Medicine

Volume: 18, P: 563-569
Effects of uric acid on ischemic diseases, stratified by lipid levels: a drug-target, nonlinear Mendelian randomization study

Jungeun Kim
Sun Yeop Lee
Sang-In Park
ResearchOpen Access16 Jan 2024
Scientific Reports

Volume: 14, P: 1-7
Genetic Characteristics of Korean Patients with Autosomal Dominant Polycystic Kidney Disease by Targeted Exome Sequencing

Hyunsuk Kim
Hayne Cho Park
Curie Ahn
ResearchOpen Access18 Nov 2019
Scientific Reports

Volume: 9, P: 1-11
Incidence and risk of pancreatic cancer in patients with acute or chronic pancreatitis: a population-based cohort study

Seon Mee Park
Ki Bae Kim
Hyun Jung Kim
ResearchOpen Access02 Nov 2023
Scientific Reports

Volume: 13, P: 1-12
The landscape of abiotic and biotic stress-responsive splice variants with deep RNA-seq datasets in hot pepper

Nayoung Kim
Junesung Lee
Won-Hee Kang
ResearchOpen Access13 Apr 2024
Scientific Data

Volume: 11, P: 1-8
Dynamical d-wave condensation of exciton–polaritons in a two-dimensional square-lattice potential

Similar to atoms in cold gases, exciton–polaritons in semiconductor microcavities can undergo Bose–Einstein condensation. Now, formation of a condensate in an excited orbital state has been observed in such a system, underlining the potential of exciton–polariton condensates to emulate condensed-matter physics.

Na Young Kim
Kenichiro Kusudo
Yoshihisa Yamamoto
Research19 Jun 2011
Nature Physics

Volume: 7, P: 681-686
Author Correction: Whole exome sequencing for the identification of CYP3A7 variants associated with tacrolimus concentrations in kidney transplant patients

Minji Sohn
Myeong Gyu Kim
Jung Mi Oh
Amendments and CorrectionsOpen Access07 Feb 2020
Scientific Reports

Volume: 10, P: 1
Author Correction: Genetic Characteristics of Korean Patients with Autosomal Dominant Polycystic Kidney Disease by Targeted Exome Sequencing

Hyunsuk Kim
Hayne Cho Park
Curie Ahn
Amendments and CorrectionsOpen Access02 Apr 2020
Scientific Reports

Volume: 10, P: 1-2
Transformation of europium metal-organic framework from 3D via 2D into exfoliating 3D for enzyme immobilization

Metal-organic frameworks are promising materials for hosting functional biomolecules. Here, a 3D europium metal-organic framework could split into a 2D one upon solvent addition and re-cross-link to 3D with excess solvent which can host enzymes as a biocatalyst.

Ani Vardanyan
Guojun Zhou
Gulaim A. Seisenbaeva
ResearchOpen Access12 Sept 2024
Communications Materials

Volume: 5, P: 1-10
Gut microbiome signature of metabolically healthy obese individuals according to anthropometric, metabolic and inflammatory parameters

Ho-Kyoung Lee
Nam-Eun Kim
Dong Ho Lee
ResearchOpen Access11 Feb 2024
Scientific Reports

Volume: 14, P: 1-12
Loss of desmoglein-2 promotes gallbladder carcinoma progression and resistance to EGFR-targeted therapy through Src kinase activation

Sang-Hyun Lee
Jin-Man Kim
Jeong-Ki Min
ResearchOpen Access28 Sept 2020
Cell Death & Differentiation

Volume: 28, P: 968-984
Model based development of tacrolimus dosing algorithm considering CYP3A5 genotypes and mycophenolate mofetil drug interaction in stable kidney transplant recipients

Jae Hyun Kim
Nayoung Han
Jung Mi Oh
ResearchOpen Access13 Aug 2019
Scientific Reports

Volume: 9, P: 1-9
Improving genetic diagnosis by disease-specific, ACMG/AMP variant interpretation guidelines for hearing loss

So Young Kim
Bong Jik Kim
Byung Yoon Choi
ResearchOpen Access21 Jul 2022
Scientific Reports

Volume: 12, P: 1-9
Powerful use of automated prioritization of candidate variants in genetic hearing loss with extreme etiologic heterogeneity

So Young Kim
Seungmin Lee
Byung Yoon Choi
ResearchOpen Access30 Sept 2021
Scientific Reports

Volume: 11, P: 1-11
Online information analysis on pancreatic cancer in Korea using structural topic model

Wonkwang Jo
Yeol Kim
Junli Park
ResearchOpen Access23 Jun 2022
Scientific Reports

Volume: 12, P: 1-16
Increased Exposure of Tacrolimus by Co-administered Mycophenolate Mofetil: Population Pharmacokinetic Analysis in Healthy Volunteers

Jae Hyun Kim
Nayoung Han
Jung Mi Oh
ResearchOpen Access26 Jan 2018
Scientific Reports

Volume: 8, P: 1-9
Development of colorectal cancer predicts increased risk of subsequent hepatocellular carcinoma in patients with alcoholic liver disease: case-control and cohort study

Won Kim
Dongjae Jeong
Jin-Wook Kim
ResearchOpen Access01 Mar 2019
Scientific Reports

Volume: 9, P: 1-8
ATP1A3 mutations can cause progressive auditory neuropathy: a new gene of auditory synaptopathy

Kyu-Hee Han
Doo-Yi Oh
Byung Yoon Choi
ResearchOpen Access28 Nov 2017
Scientific Reports

Volume: 7, P: 1-11
Transcriptome profiling of abiotic responses to heat, cold, salt, and osmotic stress of Capsicum annuum L.

Won-Hee Kang
Young Mi Sim
Seon-In Yeom
ResearchOpen Access13 Jan 2020
Scientific Data

Volume: 7, P: 1-7
miR-96-5p targets PTEN to mediate sunitinib resistance in clear cell renal cell carcinoma

Sang Eun Park
Wonju Kim
Choung-Soo Kim
ResearchOpen Access03 Mar 2022
Scientific Reports

Volume: 12, P: 1-12

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