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Spirocyclic hypervalent iodine(III)-mediated radiofluorination of non-activated and hindered aromatics

Fluorine-18 containing molecules are important for PET imaging, but due to the short half-life it is necessary to develop rapid methods for its introduction. Here, the authors use spirocyclic iodine(III) precursors, allowing direct 18F labelling of highly functionalized non-activated arenes and PET radiopharmaceuticals.

Benjamin H. Rotstein
Nickeisha A. Stephenson
Steven H. Liang
Research09 Jul 2014
Nature Communications

Volume: 5, P: 1-7
Fatty acid amide hydrolase in major depressive episodes: A [¹¹C]CURB positron emission tomography study

Dorsa Rafiei
Michelle De Pol
Nathan J. Kolla
ResearchOpen Access23 Jun 2025
Neuropsychopharmacology

P: 1-8
Ligand-based design of [¹⁸F]OXD-2314 for PET imaging in non-Alzheimer’s disease tauopathies

[¹⁸F]OXD-2314 is a brain penetrant positron emission tomography radiotracer with high affinity for tau aggregates in Alzheimer’s disease (AD) and non-AD tauopathies based on in vitro and in vivo studies, and is suitable for first-in-human use.

Anton Lindberg
Emily Murrell
Neil Vasdev
ResearchOpen Access14 Jun 2024
Nature Communications

Volume: 15, P: 1-13
Retraction Note: Target receptor identification and subsequent treatment of resected brain tumors with encapsulated and engineered allogeneic stem cells

Deepak Bhere
Sung Hugh Choi
Khalid Shah
Amendments and CorrectionsOpen Access21 Mar 2025
Nature Communications

Volume: 16, P: 1-2
Synthesis and preliminary PET imaging of ¹¹C and ¹⁸F isotopologues of the ROS1/ALK inhibitor lorlatinib

Lorlatinib—a ROS1/ALK inhibitor—is currently undergoing clinical trials for the treatment of non-small cell lung cancers. Here the authors develop synthetic routes to¹¹C- and ¹⁸F-labelled lorlatinib, with subsequent PET imaging showing good blood brain barrier permeability in non-human primates.

Thomas Lee Collier
Marc D. Normandin
Neil Vasdev
ResearchOpen Access08 Jun 2017
Nature Communications

Volume: 8, P: 1-12
RETRACTED ARTICLE: Target receptor identification and subsequent treatment of resected brain tumors with encapsulated and engineered allogeneic stem cells

The use of cell-based therapies may be helpful in eradicating cancer cells. Here, the authors generate bifunctional mesenchymal stem cells and demonstrate their therapeutic efficacy in glioblastoma patient-derived models.

Deepak Bhere
Sung Hugh Choi
Khalid Shah
ResearchOpen Access19 May 2022
Nature Communications

Volume: 13, P: 1-16
Facile ¹⁸F labeling of non-activated arenes via a spirocyclic iodonium(III) ylide method and its application in the synthesis of the mGluR₅ PET radiopharmaceutical [¹⁸F]FPEB

¹⁸F labeling of non-activated arenes (e.g., 3-[¹⁸F]fluoro-5-[(pyridin-3-yl)ethynyl] benzonitrile ([¹⁸F]FPEB)) is an unmet need for PET imaging. This protocol uses a spirocyclic iodonium ylide method for one-step, regioselective radiofluorination.

Steven H. Liang
Lu Wang
Neil Vasdev
Protocols12 Apr 2019
Nature Protocols

Volume: 14, P: 1530-1545
Cigarette smoking is associated with reduced neuroinflammation and better cognitive control in people living with HIV

Arthur L. Brody
Anna K. Mischel
Jared W. Young
ResearchOpen Access01 Jan 2025
Neuropsychopharmacology

Volume: 50, P: 695-704
Cognitive impairment and World Trade Centre-related exposures

Here, the authors summarize the evidence concerning the neurological health of individuals affected by the 11 September 2001 terrorist attacks and present the outcome of a meeting convened by the US National Institute for Occupational Safety and Health that aimed to generate recommendations for future research in this population.

Sean A. P. Clouston
Charles B. Hall
Benjamin J. Luft
Reviews18 Nov 2021
Nature Reviews Neurology

Volume: 18, P: 103-116
Emerging targets for positron emission tomography imaging in proteinopathies

Melissa Chassé
Neil Vasdev
ReviewsOpen Access21 Aug 2024
npj Imaging

Volume: 2, P: 1-7
Serum amyloid P component (SAP) modulates antidepressant effects through promoting membrane insertion of the serotonin transporter

Ping Su
Shuxin Yan
Fang Liu
Research08 Sept 2022
Neuropsychopharmacology

Volume: 48, P: 508-517
A double-blind placebo-controlled trial of minocycline on translocator protein distribution volume in treatment-resistant major depressive disorder

Sophia Attwells
Elaine Setiawan
Jeffrey H. Meyer
ResearchOpen Access29 May 2021
Translational Psychiatry

Volume: 11, P: 1-9
Replicating predictive serum correlates of greater translocator protein distribution volume in brain

Sophia Attwells
Elaine Setiawan
Jeffrey H. Meyer
Research04 Nov 2019
Neuropsychopharmacology

Volume: 45, P: 925-931

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