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Showing 1–3 of 3 results
Advanced filters: Author: Nemanja Vujic Clear advanced filters

  • Adipose tissue (AT) inflammation is strongly associated with obesity and constitutes an obesogenic memory upon weight loss. Here, the authors show that intermittent fasting leads to an adipocyte p53-signaling dependent emergence of lipid-associated macrophages in visceral AT of obese mice which limits the systemic fasting response.

    • Isabel Reinisch
    • Helene Michenthaler
    • Andreas Prokesch
    ResearchOpen Access
    Nature Communications
    Volume: 15, P: 1-21

  • Laurent et al. develop a liver-targeted gene therapy using recombinant adeno-associated viral vector (rAAV) to effectively cure Lysosomal acid lipase deficiency. This occurs via correction of lipid accumulation and normalized gene expression patterns and mitochondrial function in Lipa−/− mice.

    • Marine Laurent
    • Rim Harb
    • Mario Amendola
    ResearchOpen Access
    Communications Medicine
    Volume: 5, P: 1-15

  • K+ plays an important role in physiology and disease, but the lack of high specificity K+ sensors limits our understanding of its spatiotemporal dynamics. Here the authors develop genetically-encoded FRET-based probes able to quantify K+ concentration in body fluids, cells and specific organelles.

    • Helmut Bischof
    • Markus Rehberg
    • Roland Malli
    ResearchOpen Access
    Nature Communications
    Volume: 8, P: 1-12