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Showing 1–7 of 7 results
Advanced filters: Author: Neta Rosenzweig Clear advanced filters

  • Immunosuppression has been unsuccessful in treatment of Alzheimer’s disease. Here the authors show in a mouse model of the disease that transient inhibition of regulatory T cells mitigates amyloid plaque pathology and reverses cognitive decline, whereas augmenting these cells worsens the pathology.

    • Kuti Baruch
    • Neta Rosenzweig
    • Michal Schwartz
    ResearchOpen Access
    Nature Communications
    Volume: 6, P: 1-12

  • Blocking the PD-1 pathway was shown to be effective in amyloid beta mouse models, yet little is known about its therapeutic potential in models of tauopathy. The authors show here that blocking PD-L1, a PD-1 ligand, is similarly effective, and that both treatments reversed cognitive deficiencies, and modified disease pathology not only in an animal model of AD, but also in the DM-hTAU mouse tauopathy model, through a mechanism that involves monocyte-derived macrophages.

    • Neta Rosenzweig
    • Raz Dvir-Szternfeld
    • Michal Schwartz
    ResearchOpen Access
    Nature Communications
    Volume: 10, P: 1-15

  • Microglia cells in the brain regulate immune responses, but in ageing can negatively affect brain function. Here the authors show that the chronic presence of type I interferon in aged mouse brain impedes cognitive ability by altering microglia transcriptome and limiting Mef2C, a microglia ‘off’ signal.

    • Aleksandra Deczkowska
    • Orit Matcovitch-Natan
    • Michal Schwartz
    ResearchOpen Access
    Nature Communications
    Volume: 8, P: 1-13

  • This Review provides an in-depth examination of how inflammation contributes to neurodegeneration in Alzheimer disease. The authors explore the impact of extrinsic factors, such as brain trauma, diet and infections, and host-intrinsic factors, such as the activity of microglial cells and other immune, vascular and neuronal cell populations, on disease development. They also highlight emerging drugs that target this inflammatory component for therapy of Alzheimer disease.

    • Michael T. Heneka
    • Wiesje M. van der Flier
    • Sean-Patrick Riechers
    Reviews
    Nature Reviews Immunology
    Volume: 25, P: 321-352