Nature Search

Whole-genome sequencing of a sporadic primary immunodeficiency cohort

Whole-genome sequencing analysis of individuals with primary immunodeficiency identifies new candidate disease-associated genes and shows how the interplay between genetic variants can explain the variable penetrance and complexity of the disease.

James E. D. Thaventhiran
Hana Lango Allen
Kenneth G. C. Smith
Research06 May 2020
Nature

Volume: 583, P: 90-95
SARS-CoV-2 evolution during treatment of chronic infection

Chronic infection with SARS-CoV-2 leads to the emergence of viral variants that show reduced susceptibility to neutralizing antibodies in an immunosuppressed individual treated with convalescent plasma.

Steven A. Kemp
Dami A. Collier
Ravindra K. Gupta
Research05 Feb 2021
Nature

Volume: 592, P: 277-282
Publisher Correction: Whole-genome sequencing of a sporadic primary immunodeficiency cohort

James E. D. Thaventhiran
Hana Lango Allen
Kenneth G. C. Smith
Amendments and Corrections17 Jul 2020
Nature

Volume: 584, P: E2
Iron dysregulation and inflammatory stress erythropoiesis associates with long-term outcome of COVID-19

Smith and colleagues find that a multivariate signature of unresolved inflammation and altered iron homeostasis detected beyond 2 weeks following acute COVID-19 onset was the strongest early differentiator of those who report long COVID symptoms at 3–10 months.

Aimee L. Hanson
Matthew P. Mulè
Kenneth G. C. Smith
ResearchOpen Access01 Mar 2024
Nature Immunology

Volume: 25, P: 471-482
Whole-genome sequencing of patients with rare diseases in a national health system

Whole-genome sequencing and phenotype data sharing are introduced in a national health system to streamline diagnosis and to discover coding and non-coding variants that cause rare diseases.

Ernest Turro
William J. Astle
Willem H. Ouwehand
Research24 Jun 2020
Nature

Volume: 583, P: 96-102
Nuclear-mitochondrial DNA segments resemble paternally inherited mitochondrial DNA in humans

Recent evidence has questioned the dogma of strict maternal transmission of mitochondrial DNA (mtDNA) in humans. Wei et al. saw no evidence of paternal transmission of mtDNA in 11,035 human trios, and show that nuclear-mitochondrial segments (NUMTs) can give the impression of paternal mtDNA transmission, but are actually inherited through the nuclear genome.

Wei Wei
Alistair T. Pagnamenta
Patrick F. Chinnery
ResearchOpen Access08 Apr 2020
Nature Communications

Volume: 11, P: 1-11
Author Correction: Nuclear-mitochondrial DNA segments resemble paternally inherited mitochondrial DNA in humans

Wei Wei
Alistair T. Pagnamenta
Patrick F. Chinnery
Amendments and CorrectionsOpen Access22 Jul 2020
Nature Communications

Volume: 11, P: 1-2
Genomic identification of cryptic susceptibility to penicillins and β-lactamase inhibitors in methicillin-resistant Staphylococcus aureus

Collateral sensitivity-inducing mutations in methicillin-resistant Staphylococcus aureus strains lead to re-sensitization of bacteria to penicillin–clavulanic acid combinatorial treatment.

Ewan M. Harrison
Xiaoliang Ba
Mark A. Holmes
Research24 Jun 2019
Nature Microbiology

Volume: 4, P: 1680-1691
Altered TMPRSS2 usage by SARS-CoV-2 Omicron impacts infectivity and fusogenicity

The spike protein of the Omicron variant of SARS-CoV-2 has a higher affinity for ACE2 than Delta, and a marked change in its antigenicity increases Omicron’s evasion of therapeutic and vaccine-elicited neutralizing antibodies.

Bo Meng
Adam Abdullahi
Ravindra K. Gupta
ResearchOpen Access01 Feb 2022
Nature

Volume: 603, P: 706-714
SARS-CoV-2 B.1.617.2 Delta variant replication and immune evasion

A study of SARS-CoV-2 variants examining their transmission, infectivity, and potential resistance to therapies provides insights into the biology of the Delta variant and its role in the global pandemic.

Petra Mlcochova
Steven A. Kemp
Ravindra K. Gupta
ResearchOpen Access06 Sept 2021
Nature

Volume: 599, P: 114-119
Author Correction: SARS-CoV-2 evolution during treatment of chronic infection

Steven A. Kemp
Dami A. Collier
Ravindra K. Gupta
Amendments and Corrections21 Jul 2022
Nature

Volume: 608, P: E23
Age-related immune response heterogeneity to SARS-CoV-2 vaccine BNT162b2

Individuals over eighty years of age are less likely to mount a good immune response against SARS-CoV-2 (measured by neutralization titres) after the first dose of the BNT162b2 mRNA vaccine, but achieve good neutralization after the second dose.

Dami A. Collier
Isabella A. T. M. Ferreira
Ravindra K. Gupta
ResearchOpen Access30 Jun 2021
Nature

Volume: 596, P: 417-422
Identification of LukPQ, a novel, equid-adapted leukocidin of Staphylococcus aureus

Gerrit Koop
Manouk Vrieling
Mark A. Holmes
ResearchOpen Access20 Jan 2017
Scientific Reports

Volume: 7, P: 1-10

Search

Whole-genome sequencing of a sporadic primary immunodeficiency cohort

SARS-CoV-2 evolution during treatment of chronic infection

Publisher Correction: Whole-genome sequencing of a sporadic primary immunodeficiency cohort

Iron dysregulation and inflammatory stress erythropoiesis associates with long-term outcome of COVID-19

Whole-genome sequencing of patients with rare diseases in a national health system

Nuclear-mitochondrial DNA segments resemble paternally inherited mitochondrial DNA in humans

Author Correction: Nuclear-mitochondrial DNA segments resemble paternally inherited mitochondrial DNA in humans

Genomic identification of cryptic susceptibility to penicillins and β-lactamase inhibitors in methicillin-resistant Staphylococcus aureus

Altered TMPRSS2 usage by SARS-CoV-2 Omicron impacts infectivity and fusogenicity

SARS-CoV-2 B.1.617.2 Delta variant replication and immune evasion

Author Correction: SARS-CoV-2 evolution during treatment of chronic infection

Age-related immune response heterogeneity to SARS-CoV-2 vaccine BNT162b2

Identification of LukPQ, a novel, equid-adapted leukocidin of Staphylococcus aureus

Search

Quick links

Search

Filter By:

Search

Quick links