Nature Search

Reduction of neuronal activity mediated by blood-vessel regression in the adult brain

The role of vascular plasticity in brain function remains poorly understood. Here, the authors demonstrate that a significant portion of blood vessels in the adult brain periodically occlude and regress, a process that is associated with a reduction in neuronal activity.

Xiaofei Gao
Xing-jun Chen
Woo-ping Ge
ResearchOpen Access01 Jul 2025
Nature Communications

Volume: 16, P: 1-18
Fine-mapping genomic loci refines bipolar disorder risk genes

This study used fine-mapping to analyze genetic regions associated with bipolar disorder, identifying specific risk genes and providing new insights into the biology of the condition that may guide future research and treatment approaches.

Maria Koromina
Ashvin Ravi
Niamh Mullins
ResearchOpen Access25 Jun 2025
Nature Neuroscience

Volume: 28, P: 1393-1403
Parasite and vector circadian clocks mediate efficient malaria transmission

Mosquito salivary glands and malaria parasites exhibit daily rhythms, which impact blood feeding and sporozoite gene expression.

Inês Bento
Brianna A. Parrington
Filipa Rijo-Ferreira
ResearchOpen Access31 Mar 2025
Nature Microbiology

Volume: 10, P: 882-896
Genomics yields biological and phenotypic insights into bipolar disorder

Using multi-ancestry genome-wide association study and fine-mapping, 298 loci and 36 credible genes are identified in the aetiology of bipolar disorder.

Kevin S. O’Connell
Maria Koromina
Dan Siskind
Research22 Jan 2025
Nature

Volume: 639, P: 968-975
Biosynthesis of ¹⁴C-Sclareol and β-Sitosterol from 2-¹⁴C-Mevalonic Acid

HAROLD J. NICHOLAS
Research14 Jan 1961
Nature

Volume: 189, P: 143-144
Demonstration and Implications of Lysozyme and Immunoglobulins in Human Ear Wax

NICHOLAS L. PETRAKIS
MARIE DOHERTY
N. L. PAGE
Research08 Jan 1971
Nature

Volume: 229, P: 119-120
Genome-wide association study of more than 40,000 bipolar disorder cases provides new insights into the underlying biology

Genome-wide association analyses of 41,917 bipolar disorder cases and 371,549 controls of European ancestry provide new insights into the etiology of this disorder and identify novel therapeutic leads and potential opportunities for drug repurposing.

Niamh Mullins
Andreas J. Forstner
Ole A. Andreassen
Research17 May 2021
Nature Genetics

Volume: 53, P: 817-829
Altered microbial bile acid metabolism exacerbates T cell-driven inflammation during graft-versus-host disease

Graft-versus-host disease, a T cell-driven inflammatory condition, is associated with altered microbial bile acid metabolism in both mice and humans and this is linked to outcomes.

Sarah Lindner
Oriana Miltiadous
Marcel R. M. van den Brink
Research01 Mar 2024
Nature Microbiology

Volume: 9, P: 614-630
Genome-wide association study identifies 30 loci associated with bipolar disorder

Genome-wide analysis identifies 30 loci associated with bipolar disorder, allowing for comparisons of shared genes and pathways with other psychiatric disorders, including schizophrenia and depression.

Eli A. Stahl
Gerome Breen
Pamela Sklar
Research01 May 2019
Nature Genetics

Volume: 51, P: 793-803
The therapeutic implications of all-in-one AAV-delivered epigenome-editing platform in neurodegenerative disorders

Adeno-associated vectors (AAVs) are frequently used for the delivery of genetic cargo but their small packaging capacity is not suitable for delivery of large constructs, including most CRISPR/dCas9-effector systems. Here the authors report a compact dCas9-based repressor system packaged within a single, optimized AAV vector.

Boris Kantor
Bernadette O’Donovan
Ornit Chiba-Falek
ResearchOpen Access23 Aug 2024
Nature Communications

Volume: 15, P: 1-15
Bipolar multiplex families have an increased burden of common risk variants for psychiatric disorders

Till F. M. Andlauer
Jose Guzman-Parra
Marcella Rietschel
ResearchOpen Access11 Nov 2019
Molecular Psychiatry

Volume: 26, P: 1286-1298
Alterations in Body Temperature, Corticosterone, and Behavior Following the Administration of 5-Methoxy-Diisopropyltryptamine (‘Foxy’) to Adult Rats: a New Drug of Abuse

Michael T Williams
Nicole R Herring
Charles V Vorhees
Research18 Oct 2006
Neuropsychopharmacology

Volume: 32, P: 1404-1420
Association of polygenic score for major depression with response to lithium in patients with bipolar disorder

Azmeraw T. Amare
Klaus Oliver Schubert
Bernhard T. Baune
Research16 Mar 2020
Molecular Psychiatry

Volume: 26, P: 2457-2470
Long-term effects of medical management on growth and weight in individuals with urea cycle disorders

Roland Posset
Sven F. Garbade
Maja Djordjevic
ResearchOpen Access20 Jul 2020
Scientific Reports

Volume: 10, P: 1-13

Search

Reduction of neuronal activity mediated by blood-vessel regression in the adult brain

Fine-mapping genomic loci refines bipolar disorder risk genes

Parasite and vector circadian clocks mediate efficient malaria transmission

Genomics yields biological and phenotypic insights into bipolar disorder

Biosynthesis of ¹⁴C-Sclareol and β-Sitosterol from 2-¹⁴C-Mevalonic Acid

Demonstration and Implications of Lysozyme and Immunoglobulins in Human Ear Wax

Genome-wide association study of more than 40,000 bipolar disorder cases provides new insights into the underlying biology

Altered microbial bile acid metabolism exacerbates T cell-driven inflammation during graft-versus-host disease

Genome-wide association study identifies 30 loci associated with bipolar disorder

The therapeutic implications of all-in-one AAV-delivered epigenome-editing platform in neurodegenerative disorders

Bipolar multiplex families have an increased burden of common risk variants for psychiatric disorders

Alterations in Body Temperature, Corticosterone, and Behavior Following the Administration of 5-Methoxy-Diisopropyltryptamine (‘Foxy’) to Adult Rats: a New Drug of Abuse

Association of polygenic score for major depression with response to lithium in patients with bipolar disorder

Long-term effects of medical management on growth and weight in individuals with urea cycle disorders

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