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Showing 1–17 of 17 results
Advanced filters: Author: Nicola Elvassore Clear advanced filters

  • Proteins secreted by hepatic cells can be harnessed to grow miniature organs in the lab.

    • Nicola Nosengo
    Research Highlights
    Nature Italy

  • Le proteine prodotte dalle cellule epatiche possono essere sfruttate per far crescere in laboratorio organi in miniatura.

    • Nicola Nosengo
    Research Highlights
    Nature Italy

  • Hydrogel force sensors directly bioprinted into embryonic tissues quantify the forces driving tissue remodelling and reveal the existence of mechanisms that counteract tissue morphogenesis.

    • Eirini Maniou
    • Silvia Todros
    • Nicola Elvassore
    ResearchOpen Access
    Nature Materials
    Volume: 23, P: 1575-1581

  • The contribution of cell-extrinsic factors during cellular reprogramming to human induced pluripotent stem cells has long been overlooked. Here, the authors show functional protein communication between reprogramming intermediates and the re-shaping of a permissive extracellular environment.

    • Francesco Panariello
    • Onelia Gagliano
    • Nicola Elvassore
    ResearchOpen Access
    Nature Communications
    Volume: 14, P: 1-15

  • Several clinical reports have described gastrointestinal symptoms for COVID-19, though whether the virus can replicate within the stomach remains unclear. Here the authors generate gastric organoids from human biopsies and show that the virus can efficiently infect gastric epithelium, suggesting that the stomach might have an active role in fecal-oral transmission.

    • Giovanni Giuseppe Giobbe
    • Francesco Bonfante
    • Paolo De Coppi
    ResearchOpen Access
    Nature Communications
    Volume: 12, P: 1-14

  • Organoid cultures have been developed from multiple tissues, opening new possibilities for regenerative medicine. Here the authors demonstrate the derivation of GMP-compliant hydrogels from decellularized porcine small intestine which support formation and growth of human gastric, liver, pancreatic and small intestinal organoids.

    • Giovanni Giuseppe Giobbe
    • Claire Crowley
    • Paolo De Coppi
    ResearchOpen Access
    Nature Communications
    Volume: 10, P: 1-14

  • Organ-like 3D cultures are advanced model system for biology and medicine limited by their uncontrolled cell self-assembly. Here, the authors develop a hydrogel-in-hydrogel bioprinting approach to dynamically control the growth landscape of a broad range of living 3D cell cultures.

    • Anna Urciuolo
    • Giovanni Giuseppe Giobbe
    • Nicola Elvassore
    ResearchOpen Access
    Nature Communications
    Volume: 14, P: 1-14

  • Chronic desynchronization between physiological and behavioral rhythms has been linked to the onset of metabolic diseases. Here the authors control the cyclic metabolic signals in a microfluidic device to study the effects of the timing, period and frequency of glucose and insulin on the transcriptome of cultured fibroblasts.

    • Onelia Gagliano
    • Camilla Luni
    • Nicola Elvassore
    ResearchOpen Access
    Nature Communications
    Volume: 12, P: 1-12

  • The roles of CoQ10 and producing enzymes in cancer have not been well explored. Here, the authors identify that the CoQ10-biosynthetic enzyme UBIAD1 is a tumor suppressor in breast cancer. CoQ10 induced alterations in plasma membrane mechanical properties lead to increased cellular stiffness and impaired tumorigenic signaling, as well as enhanced sensitivity to ferroptosis.

    • Giovanni Tosi
    • Alessandro Paoli
    • Massimo M. Santoro
    ResearchOpen Access
    Nature Communications
    Volume: 15, P: 1-24

  • Three-dimensional cell-laden photosensitive polymer hydrogels can be bioprinted in tissues of live animals, by bio-orthogonal two-photon cycloaddition and crosslinking of the polymers.

    • Anna Urciuolo
    • Ilaria Poli
    • Nicola Elvassore
    Research
    Nature Biomedical Engineering
    Volume: 4, P: 901-915

  • Microfluidic reprogramming of human somatic cells to induced pluripotent stem cells is rapid and highly efficient, enabling large-scale derivation from patient cells as well as seamless on-chip differentiation without cell expansion.

    • Camilla Luni
    • Stefano Giulitti
    • Nicola Elvassore
    Research
    Nature Methods
    Volume: 13, P: 446-452

  • Romani et al. report that cells on soft extracellular matrix have increased mitochondrial fission, with subsequent production of mitochondrial reactive oxygen species and NRF2, which may increase resistance to reactive oxygen species-dependent chemotherapy drugs in breast cancer cells in vitro and in mouse lungs.

    • Patrizia Romani
    • Nunzia Nirchio
    • Sirio Dupont
    Research
    Nature Cell Biology
    Volume: 24, P: 168-180

  • This paper shows that microfluidic perfusion frequency can be optimized to improve the differentiation of human pluripotent stem cells along different lineages, and uses this principle to achieve functional hPSC differentiation directly on a chip.

    • Giovanni G Giobbe
    • Federica Michielin
    • Nicola Elvassore
    Research
    Nature Methods
    Volume: 12, P: 637-640

  • Giulitti et al. deliver modified mRNAs encoding OCT3/4, SOX2, KLF4 and cMYC as well as NANOG in microfluidics to directly convert human fibroblasts into naive induced pluripotent stem cells; the confined environment leads to enhanced efficiency and homogeneity compared to traditional methods.

    • Stefano Giulitti
    • Marco Pellegrini
    • Graziano Martello
    Research
    Nature Cell Biology
    Volume: 21, P: 275-286

  • This protocol describes how to use a microfluidics system to produce human induced pluripotent stem cells at high efficiency and low cost using a small starting cell number.

    • Onelia Gagliano
    • Camilla Luni
    • Nicola Elvassore
    Protocols
    Nature Protocols
    Volume: 14, P: 722-737