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Showing 1–8 of 8 results
Advanced filters: Author: Nicolas Altemose Clear advanced filters

  • DiMeLo-seq uses long-read, single-molecule sequencing to map protein–DNA interactions genome wide. This allows mapping of multiple interaction sites on single DNA molecules and profiling protein binding in the context of endogenous DNA methylation.

    • Annie Maslan
    • Nicolas Altemose
    • Aaron Streets
    Protocols
    Nature Protocols
    Volume: 19, P: 3697-3720

  • We present the complete 62,460,029-base-pair sequence of a human Y chromosome from the HG002 genome (T2T-Y) that corrects multiple errors in GRCh38-Y and adds over 30 million base pairs of sequence to the reference.

    • Arang Rhie
    • Sergey Nurk
    • Adam M. Phillippy
    Research
    Nature
    Volume: 621, P: 344-354

  • During meiotic recombination, genetic information is transferred or exchanged between parental chromosome copies. Using a large hybrid mouse pedigree, the authors generated high-resolution maps of these transfer/exchange events and discovered new properties governing their processing and resolution.

    • Ran Li
    • Emmanuelle Bitoun
    • Simon R. Myers
    ResearchOpen Access
    Nature Communications
    Volume: 10, P: 1-15

  • Extrachromosomal DNA makes cancerous tumours resistant to treatment, but this research demonstrates that increasing transcription–replication conflict allows for targeted elimination of cancer cells containing extrachromosomal DNA, and thus sustained tumour regression in mice.

    • Jun Tang
    • Natasha E. Weiser
    • Howard Y. Chang
    ResearchOpen Access
    Nature
    Volume: 635, P: 210-218

  • PRDM9 is a DNA-binding protein that controls the position of double-strand breaks in meiosis, and the gene that encodes it is responsible for hybrid infertility between closely related mouse species; this hybrid infertility is eliminated by introducing the zinc-finger ___domain sequence from the human version of the PRDM9 gene, a change which alters both the position of double-strand breaks and the symmetry of PRDM9 binding and suggests that PRDM9 may have a more general but transient role in the early stages of speciation.

    • Benjamin Davies
    • Edouard Hatton
    • Peter Donnelly
    Research
    Nature
    Volume: 530, P: 171-176

  • Steven McCarroll, Giulio Genovese and colleagues report a new approach to help complete maps of the human genome reference sequence. They use a population-based admixture mapping approach and report the successful mapping of ~4 Mb of unplaced human euchromatic sequences.

    • Giulio Genovese
    • Robert E Handsaker
    • Steven A McCarroll
    Research
    Nature Genetics
    Volume: 45, P: 406-414