Nature Search

Systems vaccinology identifies immunological correlates of SARS-CoV-2 vaccine response in solid organ transplant recipients

Nicolas Gemander
Julika Neumann
Stephanie Humblet-Baron
ResearchOpen Access01 Jul 2025
npj Vaccines

Volume: 10, P: 1-15
Mammals show faster recovery from capture and tagging in human-disturbed landscapes

In wildlife tagging, stress from capture and handling can alter post- release behavior and potentially study interpretations. This study of 42 mammal species shows that these effects diminish within 4–7 days, and quicker for animals in high human activity areas indicating adaptation to disturbance.

Jonas Stiegler
Cara A. Gallagher
Niels Blaum
ResearchOpen Access15 Sept 2024
Nature Communications

Volume: 15, P: 1-13
Correction: Corrigendum: The seco-iridoid pathway from Catharanthus roseus

Karel Miettinen
Lemeng Dong
Danièle Werck-Reichhart
Amendments and Corrections24 Jun 2014
Nature Communications

Volume: 5, P: 1
Genomic insights into the conservation status of the world’s last remaining Sumatran rhinoceros populations

Highly endangered species like the Sumatran rhinoceros are at risk from inbreeding. Five historical and 16 modern genomes from across the species range show mutational load, but little evidence for local adaptation, suggesting that future inbreeding depression could be mitigated by assisted gene flow among populations.

Johanna von Seth
Nicolas Dussex
Love Dalén
ResearchOpen Access26 Apr 2021
Nature Communications

Volume: 12, P: 1-11
Structural insight into Tn3 family transposition mechanism

Here the structure of transposase from Tn3 family is reported in apo form and bound to the transposon ends. The activation of the transposase induces metamorphic refolding of the catalytic ___domain suggesting the family-specific regulation mechanism.

Alexander V. Shkumatov
Nicolas Aryanpour
Rouslan G. Efremov
ResearchOpen Access18 Oct 2022
Nature Communications

Volume: 13, P: 1-12
A human liver cell-based system modeling a clinical prognostic liver signature for therapeutic discovery

Drug and target discovery for advanced liver disease are hampered by a lack of suitable models for clinical translation. Here the authors present a human liver cell-based system modeling a clinical prognostic signature allowing to propose nizatidine for treatment of advanced liver fibrosis and hepatocellular carcinoma prevention.

Emilie Crouchet
Simonetta Bandiera
Thomas F. Baumert
ResearchOpen Access17 Sept 2021
Nature Communications

Volume: 12, P: 1-19
The seco-iridoid pathway from Catharanthus roseus

The (seco)iridoids and their monoterpenoid indole alkaloid (MIA) derivatives are plant-derived compounds with pharmaceutical applications. Here, the authors identify the last four missing steps of the (seco)iridoid pathway, which they reconstitute in an alternative plant host to produce the complex MIA, strictosidine.

Karel Miettinen
Lemeng Dong
Danièle Werck-Reichhart
ResearchOpen Access07 Apr 2014
Nature Communications

Volume: 5, P: 1-12
CanScreen5, a global repository for breast, cervical and colorectal cancer screening programs

In the first results from an ongoing global cancer screening data repository, screening program organization was better overall in Europe compared to other continents; however, there were substantial gaps in implementation across both high- and low-resource settings.

Li Zhang
Isabel Mosquera
Melanie Ann Layne
ResearchOpen Access27 Apr 2023
Nature Medicine

Volume: 29, P: 1135-1145
Transcriptome-based repurposing of apigenin as a potential anti-fibrotic agent targeting hepatic stellate cells

Daniel F. Hicks
Nicolas Goossens
Scott L. Friedman
ResearchOpen Access03 Mar 2017
Scientific Reports

Volume: 7, P: 1-8
The XBP1 Arm of the Unfolded Protein Response Induces Fibrogenic Activity in Hepatic Stellate Cells Through Autophagy

Rosa S. Kim
Daisuke Hasegawa
Scott L. Friedman
ResearchOpen Access20 Dec 2016
Scientific Reports

Volume: 6, P: 1-9
Autophagy is a gatekeeper of hepatic differentiation and carcinogenesis by controlling the degradation of Yap

Increased levels of the Yap oncoprotein stimulate liver growth and promote hepatocarcinogenesis. Here the authors show that hepatocyte-specific loss of Atg7 in mice leads to decreased autophagic degradation of Yap and liver overgrowth, and further establish this association in human liver cancer tissues.

Youngmin A. Lee
Luke A. Noon
Scott L. Friedman
ResearchOpen Access23 Nov 2018
Nature Communications

Volume: 9, P: 1-12
Hepatic protein tyrosine phosphatase receptor gamma links obesity-induced inflammation to insulin resistance

During obesity, chronic inflammation leads to insulin resistance and diabetes. Here, Brenachot et al. show that Protein Tyrosine Phosphatase Receptor Gamma is upregulated in obesity by inflammatory signals and correlates with insulin resistance in humans. Its deletion in mouse models of obesity and inflammation ameliorates insulin resistance by suppressing glucose production.

Xavier Brenachot
Giorgio Ramadori
Roberto Coppari
ResearchOpen Access28 Nov 2017
Nature Communications

Volume: 8, P: 1-9
Ectopic lymphoid structures function as microniches for tumor progenitor cells in hepatocellular carcinoma

Ectopic lymphoid structures develop at sites of chronic inflammation and are generally thought to be beneficial in the control of cancer. Pikarsky and colleagues show that these structures can instead nurture liver tumor progenitor cells.

Shlomi Finkin
Detian Yuan
Eli Pikarsky
Research01 Dec 2015
Nature Immunology

Volume: 16, P: 1235-1244
Measurement of the inelastic proton–proton cross-section at √s=7 TeV with the ATLAS detector

The measurement of the total cross-section of proton–proton collisions is of fundamental importance for particle physics. Here, the first measurement of the inelastic cross-section is presented for proton–proton collisions at an energy of 7 teraelectronvolts using the ATLAS detector at the Large Hadron Collider.

G. Aad
B. Abbott
L. Zwalinski
ResearchOpen Access06 Sept 2011
Nature Communications

Volume: 2, P: 1-14
Anthropogenic perturbation of the carbon fluxes from land to ocean

A substantial amount of atmospheric carbon taken up on land is transported laterally from upland terrestrial ecosystems to the ocean. A synthesis of the available literature suggests that human activities have significantly increased soil carbon inputs to inland waters, but have only slightly affected carbon delivery to the open ocean.

Pierre Regnier
Pierre Friedlingstein
Martin Thullner
Reviews09 Jun 2013
Nature Geoscience

Volume: 6, P: 597-607
In vivo dynamics of active edema and lethal factors during anthrax

Clémence Rougeaux
François Becher
Pierre L. Goossens
ResearchOpen Access21 Mar 2016
Scientific Reports

Volume: 6, P: 1-16
Socio-ecological factors shape the distribution of a cultural keystone species in Malaysian Borneo

David J. Kurz
Thomas Connor
Justin S. Brashares
ResearchOpen Access17 Feb 2023
npj Biodiversity

Volume: 2, P: 1-9
ANGPTL4 is a potential driver of HCV-induced peripheral insulin resistance

Diana Gomes
Cyril Sobolewski
Sophie Clément
ResearchOpen Access25 Apr 2023
Scientific Reports

Volume: 13, P: 1-12
Correction: Corrigendum: In vivo dynamics of active edema and lethal factors during anthrax

Clémence Rougeaux
François Becher
Pierre L. Goossens
Amendments and CorrectionsOpen Access13 Feb 2017
Scientific Reports

Volume: 7, P: 1-2
Abdominal pain patterns during COVID-19: an observational study

Alexandre Balaphas
Kyriaki Gkoufa
Christian Toso
ResearchOpen Access29 Aug 2022
Scientific Reports

Volume: 12, P: 1-9
Repositioning of a novel GABA-B receptor agonist, AZD3355 (Lesogaberan), for the treatment of non-alcoholic steatohepatitis

Dipankar Bhattacharya
Christine Becker
Scott L. Friedman
ResearchOpen Access21 Oct 2021
Scientific Reports

Volume: 11, P: 1-17
Integrin alpha 11 in the regulation of the myofibroblast phenotype: implications for fibrotic diseases

Ruchi Bansal
Shigeki Nakagawa
Jai Prakash
ResearchOpen Access17 Nov 2017
Experimental & Molecular Medicine

Volume: 49, P: e396

Search

Systems vaccinology identifies immunological correlates of SARS-CoV-2 vaccine response in solid organ transplant recipients

Mammals show faster recovery from capture and tagging in human-disturbed landscapes

Correction: Corrigendum: The seco-iridoid pathway from Catharanthus roseus

Genomic insights into the conservation status of the world’s last remaining Sumatran rhinoceros populations

Structural insight into Tn3 family transposition mechanism

A human liver cell-based system modeling a clinical prognostic liver signature for therapeutic discovery

The seco-iridoid pathway from Catharanthus roseus

CanScreen5, a global repository for breast, cervical and colorectal cancer screening programs

Transcriptome-based repurposing of apigenin as a potential anti-fibrotic agent targeting hepatic stellate cells

The XBP1 Arm of the Unfolded Protein Response Induces Fibrogenic Activity in Hepatic Stellate Cells Through Autophagy

Autophagy is a gatekeeper of hepatic differentiation and carcinogenesis by controlling the degradation of Yap

Hepatic protein tyrosine phosphatase receptor gamma links obesity-induced inflammation to insulin resistance

Ectopic lymphoid structures function as microniches for tumor progenitor cells in hepatocellular carcinoma

Measurement of the inelastic proton–proton cross-section at √s=7 TeV with the ATLAS detector

Anthropogenic perturbation of the carbon fluxes from land to ocean

In vivo dynamics of active edema and lethal factors during anthrax

Socio-ecological factors shape the distribution of a cultural keystone species in Malaysian Borneo

ANGPTL4 is a potential driver of HCV-induced peripheral insulin resistance

Correction: Corrigendum: In vivo dynamics of active edema and lethal factors during anthrax

Abdominal pain patterns during COVID-19: an observational study

Repositioning of a novel GABA-B receptor agonist, AZD3355 (Lesogaberan), for the treatment of non-alcoholic steatohepatitis

Integrin alpha 11 in the regulation of the myofibroblast phenotype: implications for fibrotic diseases

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