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PGE₂ inhibits TIL expansion by disrupting IL-2 signalling and mitochondrial function

Prostaglandin E2 from the tumour microenvironment impairs interleukin-2 sensing by tumour-infiltrating lymphocytes, restricting proliferative response and promoting T cell death via metabolic impairment and ferroptosis.

Matteo Morotti
Alizee J. Grimm
George Coukos
ResearchOpen Access24 Apr 2024
Nature

Volume: 629, P: 426-434

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PGE2 inhibits TIL expansion by disrupting IL-2 signalling and mitochondrial function

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PGE₂ inhibits TIL expansion by disrupting IL-2 signalling and mitochondrial function