Nature Search

Complementing muscle regeneration—fibro-adipogenic progenitor and macrophage-mediated repair of elderly human skeletal muscle

Successful skeletal muscle regeneration involves a complex and finely tuned inter-cellular response. Here, by using spatial transcriptomics, the authors identify an intercellular communication axis between fibro-adipogenic progenitors and macrophages to enhance macrophage-mediated tissue repair.

Jonas Brorson
Lin Lin
Jean Farup
ResearchOpen Access05 Jun 2025
Nature Communications

Volume: 16, P: 1-14
Metformin reduces liver glucose production by inhibition of fructose-1-6-bisphosphatase

The antidiabetic action of metformin raises heptocyte intracellular AMP levels, causing allosteric inhibition of fructose-1,6-bisphosphatase and thus reductions in gluconeogenesis.

Roger W. Hunter
Curtis C. Hughey
Kei Sakamoto
Research27 Aug 2018
Nature Medicine

Volume: 24, P: 1395-1406
Widespread horse-based mobility arose around 2200 bce in Eurasia

Analyses of 475 ancient horse genomes show modern horses emerged around 2200 bce, coinciding with sudden expansion across Eurasia, refuting the narrative of large horse herds accompanying earlier migrations of steppe peoples across Europe.

Pablo Librado
Gaetan Tressières
Ludovic Orlando
ResearchOpen Access06 Jun 2024
Nature

Volume: 631, P: 819-825
YKL-40 and risk of incident cancer in early type 2 diabetes: a Danish cohort study

Alisa D. Kjaergaard
Allan A. Vaag
Niels Jessen
ResearchOpen Access05 Apr 2025
British Journal of Cancer

Volume: 132, P: 1019-1026
Blood biomarkers confirm subjective cognitive decline (SCD) as a distinct molecular and clinical stage within the NIA-AA framework of Alzheimer´s disease

David Mengel
Ester Soter
Matthis Synofzik
ResearchOpen Access18 Apr 2025
Molecular Psychiatry

Volume: 30, P: 3150-3159
Failure of central nervous system myelination in MBP/c-myc transgenic mice: evidence for c-myc cytotoxicity

Niels A Jensen
Karen M Pedersen
Mark J West
Research30 Apr 1998
Oncogene

Volume: 16, P: 2123-2129
Blood-based quantification of Aβ oligomers indicates impaired clearance from brain in ApoE ε4 positive subjects

Bloemeke et al. develop a method for measuring Aβ oligomers in plasma to diagnose Alzheimer’s Disease. Correlation analysis between cerebral spinal fluid and plasma oligomer concentrations indicates an impaired clearance of Aβ oligomers that is dependent on ApoE ε4 status.

Lara Blömeke
Fabian Rehn
Dieter Willbold
ResearchOpen Access10 Dec 2024
Communications Medicine

Volume: 4, P: 1-13
Population genomics of the Viking world

Ancient DNA analyses reveal that Viking Age migrations from Scandinavia resulted in differential influxes of ancestry to different parts of Europe, and the increased presence of non-local ancestry within Scandinavia.

Ashot Margaryan
Daniel J. Lawson
Eske Willerslev
Research16 Sept 2020
Nature

Volume: 585, P: 390-396
Massively targeted evaluation of therapeutic CRISPR off-targets in cells

Thorough evaluation of CRISPR RNA-guided nucleases off-targets in cells is required for advancing gene therapies. Here the authors report SURRO-seq for the simultaneous investigation of thousands of off-target sites for therapeutic RNA-guided nucleases in cells.

Xiaoguang Pan
Kunli Qu
Yonglun Luo
ResearchOpen Access13 Jul 2022
Nature Communications

Volume: 13, P: 1-14
Exercise and type 2 diabetes mellitus—good for body and mind?

Exercise has undisputed benefits for patients with type 2 diabetes mellitus, as it helps improve glycemic control, cardiovascular disease risk and body weight. In healthy people, regular exercise also improves mental health and mood, but the assumption that a similar improvement occurs in patients with type 2 diabetes mellitus has now been challenged.

Niels Jessen
Laurie J. Goodyear
News & Views01 Jun 2010
Nature Reviews Endocrinology

Volume: 6, P: 303-304
Acyl Ghrelin Induces Insulin Resistance Independently of GH, Cortisol, and Free Fatty Acids

Esben T. Vestergaard
Niels Jessen
Jens Otto Lunde Jørgensen
ResearchOpen Access15 Feb 2017
Scientific Reports

Volume: 7, P: 1-10
Author Correction: Population genomics of the Viking world

Ashot Margaryan
Daniel J. Lawson
Eske Willerslev
Amendments and Corrections11 Mar 2021
Nature

Volume: 591, P: E29
Endothelial cell heterogeneity and microglia regulons revealed by a pig cell landscape at single-cell level

Pigs are important large animal models for biomedical research. Here, the authors construct a single-cell landscape of pig tissues, unravelling the phenotypic heterogeneity of blood endothelial cells in adipose tissues and the evolutionally conserved regulons of microglia in brains.

Fei Wang
Peiwen Ding
Yonglun Luo
ResearchOpen Access24 Jun 2022
Nature Communications

Volume: 13, P: 1-18
Author Correction: Endothelial cell heterogeneity and microglia regulons revealed by a pig cell landscape at single-cell level

Fei Wang
Peiwen Ding
Yonglun Luo
Amendments and CorrectionsOpen Access08 Nov 2022
Nature Communications

Volume: 13, P: 1-2
FGF6 and FGF9 regulate UCP1 expression independent of brown adipogenesis

Uncoupling protein-1 (UCP1) plays a central role in energy dissipation in brown adipose tissue. Here the authors show that FGF6 and FGF9 induce UCP1 expression in adipocytes and preadipocytes, via modulation of a transcriptional network that is dissociated from brown adipogenesis.

Farnaz Shamsi
Ruidan Xue
Yu-Hua Tseng
ResearchOpen Access17 Mar 2020
Nature Communications

Volume: 11, P: 1-16
Altered gene expression and repressed markers of autophagy in skeletal muscle of insulin resistant patients with type 2 diabetes

Andreas Buch Møller
Ulla Kampmann
Niels Jessen
ResearchOpen Access02 Mar 2017
Scientific Reports

Volume: 7, P: 1-11
ADRA1A–Gα_q signalling potentiates adipocyte thermogenesis through CKB and TNAP

Rahbani et al. show that the α₁-adrenergic receptor potentiates thermogenesis in thermogenic adipocytes, acting via Gα_q signalling, creatine kinase B and tissue-non-specific alkaline phosphatase.

Janane F. Rahbani
Charlotte Scholtes
Lawrence Kazak
ResearchOpen Access07 Nov 2022
Nature Metabolism

Volume: 4, P: 1459-1473
The challenges of assessing adiposity in a clinical setting

Accurate measurement of adiposity and adipose tissue distribution is essential for the treatment of obesity and cardiometabolic disease, but can often prove challenging. This Perspective discusses the advantages and disadvantages of different methods of assessing adiposity in clinical settings.

Emma Börgeson
Saeideh Tavajoh
Niels Jessen
Reviews15 Jul 2024
Nature Reviews Endocrinology

Volume: 20, P: 615-626
Investigating the causal effect of smoking on hay fever and asthma: a Mendelian randomization meta-analysis in the CARTA consortium

Tea Skaaby
Amy E. Taylor
Allan Linneberg
ResearchOpen Access22 May 2017
Scientific Reports

Volume: 7, P: 1-9
Oral supplementation of nicotinamide riboside alters intestinal microbial composition in rats and mice, but not humans

A. Augusto Peluso
Agnete T. Lundgaard
Jonas T. Treebak
ResearchOpen Access03 Apr 2023
npj Aging

Volume: 9, P: 1-21
Metabolic maturation in the infant urine during the first 3 months of life

Julie Astono
Katrine O. Poulsen
Ulrik K. Sundekilde
ResearchOpen Access08 Mar 2024
Scientific Reports

Volume: 14, P: 1-11
Results from ¹¹C-metformin-PET scans, tissue analysis and cellular drug-sensitivity assays questions the view that biguanides affects tumor respiration directly

Ane B. Iversen
Michael R. Horsman
Morten Busk
ResearchOpen Access25 Aug 2017
Scientific Reports

Volume: 7, P: 1-13
Renoprotective Effects of Metformin are Independent of Organic Cation Transporters 1 & 2 and AMP-activated Protein Kinase in the Kidney

Michael Christensen
Jonas B. Jensen
Rikke Nørregaard
ResearchOpen Access26 Oct 2016
Scientific Reports

Volume: 6, P: 1-14
PEN2: Metformin’s new partner at lysosome

Kei Sakamoto
Niels Jessen
Research Highlights13 Apr 2022
Cell Research

Volume: 32, P: 507-508

Search

Complementing muscle regeneration—fibro-adipogenic progenitor and macrophage-mediated repair of elderly human skeletal muscle

Metformin reduces liver glucose production by inhibition of fructose-1-6-bisphosphatase

Widespread horse-based mobility arose around 2200 bce in Eurasia

YKL-40 and risk of incident cancer in early type 2 diabetes: a Danish cohort study

Blood biomarkers confirm subjective cognitive decline (SCD) as a distinct molecular and clinical stage within the NIA-AA framework of Alzheimer´s disease

Failure of central nervous system myelination in MBP/c-myc transgenic mice: evidence for c-myc cytotoxicity

Blood-based quantification of Aβ oligomers indicates impaired clearance from brain in ApoE ε4 positive subjects

Population genomics of the Viking world

Massively targeted evaluation of therapeutic CRISPR off-targets in cells

Exercise and type 2 diabetes mellitus—good for body and mind?

Acyl Ghrelin Induces Insulin Resistance Independently of GH, Cortisol, and Free Fatty Acids

Author Correction: Population genomics of the Viking world

Endothelial cell heterogeneity and microglia regulons revealed by a pig cell landscape at single-cell level

Author Correction: Endothelial cell heterogeneity and microglia regulons revealed by a pig cell landscape at single-cell level

FGF6 and FGF9 regulate UCP1 expression independent of brown adipogenesis

Altered gene expression and repressed markers of autophagy in skeletal muscle of insulin resistant patients with type 2 diabetes

ADRA1A–Gα_q signalling potentiates adipocyte thermogenesis through CKB and TNAP

The challenges of assessing adiposity in a clinical setting

Investigating the causal effect of smoking on hay fever and asthma: a Mendelian randomization meta-analysis in the CARTA consortium

Oral supplementation of nicotinamide riboside alters intestinal microbial composition in rats and mice, but not humans

Metabolic maturation in the infant urine during the first 3 months of life

Results from ¹¹C-metformin-PET scans, tissue analysis and cellular drug-sensitivity assays questions the view that biguanides affects tumor respiration directly

Renoprotective Effects of Metformin are Independent of Organic Cation Transporters 1 & 2 and AMP-activated Protein Kinase in the Kidney

PEN2: Metformin’s new partner at lysosome

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