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Praseodymium in the formal +5 oxidation state

The most common oxidation state for lanthanide elements is +3, and, beyond cerium, examples of these elements exhibiting higher oxidation states remain scarce. Now, a molecular complex of praseodymium in the +5 oxidation state has been synthesized; this compound exhibits a unique electronic structure driven by N 2p and Pr 4f orbital contributions.

Andrew C. Boggiano
Chad M. Studvick
Henry S. La Pierre
Research07 Apr 2025
Nature Chemistry

P: 1-6
Longitudinal molecular profiling elucidates immunometabolism dynamics in breast cancer

Although metabolic reprogramming within the tumour microenvironment (TME) has been reported in breast cancer, whether and how this evolves during treatment remains unclear. Here, the authors use multiple ‘omic’ analyses to examine this question in patients with breast cancer undergoing neoadjuvant chemotherapy.

Kang Wang
Ioannis Zerdes
Theodoros Foukakis
ResearchOpen Access07 May 2024
Nature Communications

Volume: 15, P: 1-24
Author Correction: Resolving tissue complexity by multimodal spatial omics modeling with MISO

Kyle Coleman
Amelia Schroeder
Mingyao Li
Amendments and Corrections06 Mar 2025
Nature Methods

Volume: 22, P: 874
Resolving tissue complexity by multimodal spatial omics modeling with MISO

MISO (MultI-modal Spatial Omics) integrates two or more spatial omics modalities, despite differences in data quality and spatial resolution for improved feature extraction and clustering to reveal biologically meaningful tissue organization.

Kyle Coleman
Amelia Schroeder
Mingyao Li
Research15 Jan 2025
Nature Methods

Volume: 22, P: 530-538
Author Correction: Resolving tissue complexity by multimodal spatial omics modeling with MISO

Kyle Coleman
Amelia Schroeder
Mingyao Li
Amendments and Corrections24 Jan 2025
Nature Methods

Volume: 22, P: 635
The virulence regulator VirB from Shigella flexneri uses a CTP-dependent switch mechanism to activate gene expression

Protein VirB regulates the expression of virulence genes in the pathogen Shigella flexneri by binding to DNA sequences far upstream of their promoters. Here, Jakob et al. show that VirB acts as a CTP-dependent molecular switch that uses a loading-and-sliding mechanism to control transcription of its target genes.

Sara Jakob
Wieland Steinchen
Martin Thanbichler
ResearchOpen Access05 Jan 2024
Nature Communications

Volume: 15, P: 1-18
Cell-type-directed design of synthetic enhancers

Deep learning models were used to design synthetic cell-type-specific enhancers that work in fruit fly brains and human cell lines, an approach that also provides insights into these gene regulatory elements.

Ibrahim I. Taskiran
Katina I. Spanier
Stein Aerts
ResearchOpen Access12 Dec 2023
Nature

Volume: 626, P: 212-220
Genetics of circulating inflammatory proteins identifies drivers of immune-mediated disease risk and therapeutic targets

Here the authors identify genetic effectors of the level of inflammation-related plasma proteins and use Mendelian randomization to identify proteins that contribute to immune-mediated disease risk.

Jing Hua Zhao
David Stacey
James E. Peters
ResearchOpen Access10 Aug 2023
Nature Immunology

Volume: 24, P: 1540-1551
Pathogen evasion of social immunity

Social insects often groom nestmates as an anti-pathogen behaviour, providing social immunity. Here the authors show that anti-fungal grooming behaviour by ants selects for the fungus to produce more but less-virulent and less-detectable spores, suggesting pathogen adaptation to social immunity.

Miriam Stock
Barbara Milutinović
Sylvia Cremer
ResearchOpen Access02 Feb 2023
Nature Ecology & Evolution

Volume: 7, P: 450-460
Staufen2-mediated RNA recognition and localization requires combinatorial action of multiple domains

The Staufen family of RNA-binding proteins are conserved microtubule dependent mRNA transporter factors. Here the authors use biochemical and functional approaches to characterize the RNA-binding properties of mouse Staufen 2 and study the mRNA binding capacity of its two domains dsRBDs 1 and 2.

Simone Heber
Imre Gáspár
Dierk Niessing
ResearchOpen Access10 Apr 2019
Nature Communications

Volume: 10, P: 1-16
MTH1 inhibition eradicates cancer by preventing sanitation of the dNTP pool

In order to find a general treatment for cancer, this study found that MTH1 activity is essential for the survival of transformed cells, and isolated two small-molecule inhibitors of MTH1, TH287 and TH588 — in the presence of these inhibitors, damaged nucleotides are incorporated into DNA only in cancer cells, causing cytotoxicity and eliciting a beneficial response in patient-derived mouse xenograft models.

Helge Gad
Tobias Koolmeister
Thomas Helleday
Research02 Apr 2014
Nature

Volume: 508, P: 215-221
Lake Ohrid’s tephrochronological dataset reveals 1.36 Ma of Mediterranean explosive volcanic activity

Niklas Leicher
Biagio Giaccio
Bernd Wagner
ResearchOpen Access02 Sept 2021
Scientific Data

Volume: 8, P: 1-14
Copenhagen Accord pledges are paltry

Current national emissions targets can't limit global warming to 2 °C, calculate Joeri Rogelj, Malte Meinshausen and colleagues — they might even lock the world into exceeding 3 °C warming.

Joeri Rogelj
Julia Nabel
Niklas Höhne
Comments & Opinion21 Apr 2010
Nature

Volume: 464, P: 1126-1128
A neuroadaptive interface shows intentional control alters the experience of time

Michiel Spapé
Imtiaj Ahmed
Niklas Ravaja
ResearchOpen Access19 Mar 2025
Scientific Reports

Volume: 15, P: 1-15
DNA aptamers against bacterial cells can be efficiently selected by a SELEX process using state-of-the art qPCR and ultra-deep sequencing

Claudia Kolm
Isabella Cervenka
Georg H. Reischer
ResearchOpen Access01 Dec 2020
Scientific Reports

Volume: 10, P: 1-16
Combinatorial, additive and dose-dependent drug–microbiome associations

An analysis of 2,173 individuals from the MetaCardis cohort quantifies the individual and combinatorial effects of a range of drugs on host health, metabolome and gut microbiome in cardiometabolic disease.

Sofia K. Forslund
Rima Chakaroun
Peer Bork
Research08 Dec 2021
Nature

Volume: 600, P: 500-505
Amyloid-associated increases in soluble tau relate to tau aggregation rates and cognitive decline in early Alzheimer’s disease

The interplay between amyloid and tau pathology in Alzheimer’s disease is still not well understood. Here, the authors show that amyloid-related increased in soluble p-tau is related to subsequent accumulation of tau aggregates and cognitive decline in early stage of the disease.

Alexa Pichet Binette
Nicolai Franzmeier
Oskar Hansson
ResearchOpen Access04 Nov 2022
Nature Communications

Volume: 13, P: 1-16
Online monitoring of phytate content in plant residuals during wet-treatment

Niklas Widderich
Paul Bubenheim
Andreas Liese
ResearchOpen Access05 Jan 2024
Scientific Reports

Volume: 14, P: 1-11
Mediterranean winter rainfall in phase with African monsoons during the past 1.36 million years

Comparisons between past regional drivers of precipitation extremes found time series data from Lake Ohrid and modern climate models of the Mediterranean may help to reduce simulation uncertainties in predictions of the Mediterranean climate.

Bernd Wagner
Hendrik Vogel
Xiaosen Zhang
Research02 Sept 2019
Nature

Volume: 573, P: 256-260
Spread of pathological tau proteins through communicating neurons in human Alzheimer’s disease

The tau protein is theorized to spread transneuronally in Alzheimers disease, though this theory remains unproven in humans. Our simulations of epidemic-like protein spreading across human brain networks support this theory, and suggest the spreading dynamics are modified by β-amyloid

Jacob W. Vogel
Yasser Iturria-Medina
Per Wollmer
ResearchOpen Access26 May 2020
Nature Communications

Volume: 11, P: 1-15
Serum neurofilament light protein predicts clinical outcome in traumatic brain injury

Pashtun Shahim
Magnus Gren
Kaj Blennow
ResearchOpen Access07 Nov 2016
Scientific Reports

Volume: 6, P: 1-9
Global Spore Sampling Project: A global, standardized dataset of airborne fungal DNA

Otso Ovaskainen
Nerea Abrego
Tomas Roslin
ResearchOpen Access30 May 2024
Scientific Data

Volume: 11, P: 1-17
Fecal microbiome and metabolome of infants fed bovine MFGM supplemented formula or standard formula with breast-fed infants as reference: a randomized controlled trial

Xuan He
Mariana Parenti
Carolyn M. Slupsky
ResearchOpen Access12 Aug 2019
Scientific Reports

Volume: 9, P: 1-14
A locus on 19p13 modifies risk of breast cancer in BRCA1 mutation carriers and is associated with hormone receptor–negative breast cancer in the general population

Fergus Couch and colleagues report a genome-wide association study for modifiers of breast cancer susceptibility in BRCA1 mutation carriers. They identify a locus at 19p13 associated with breast cancer risk in BRCA1 mutation carriers, and further replication studies identify this locus as associated with estrogen receptor–negative breast cancer in the general population.

Antonis C Antoniou
Xianshu Wang
Fergus J Couch
Research19 Sept 2010
Nature Genetics

Volume: 42, P: 885-892
Sulfated glycosaminoglycans inhibit transglutaminase 2 by stabilizing its closed conformation

Claudia Damaris Müller
Gloria Ruiz-Gómez
Sarah Vogel
ResearchOpen Access03 Aug 2022
Scientific Reports

Volume: 12, P: 1-16
The coordinated action of VCP/p97 and GCN2 regulates cancer cell metabolism and proteostasis during nutrient limitation

Katarzyna Parzych
Paula Saavedra-García
Holger W. Auner
ResearchOpen Access09 Jan 2019
Oncogene

Volume: 38, P: 3216-3231
P53 represses pyrimidine catabolic gene dihydropyrimidine dehydrogenase (DPYD) expression in response to thymidylate synthase (TS) targeting

Prashanth Gokare
Niklas K. Finnberg
Wafik S. El-Deiry
ResearchOpen Access29 Aug 2017
Scientific Reports

Volume: 7, P: 1-12
Author Correction: Spread of pathological tau proteins through communicating neurons in human Alzheimer’s disease

Jacob W. Vogel
Yasser Iturria-Medina
Per Wollmer
Amendments and CorrectionsOpen Access05 Aug 2021
Nature Communications

Volume: 12, P: 1
The prevalence and transcriptional activity of the mucosal microbiota of ulcerative colitis patients

Aina E. Fossum Moen
Jonas Christoffer Lindstrøm
Alan G. Shand
ResearchOpen Access22 Nov 2018
Scientific Reports

Volume: 8, P: 1-12

Search

Praseodymium in the formal +5 oxidation state

Longitudinal molecular profiling elucidates immunometabolism dynamics in breast cancer

Author Correction: Resolving tissue complexity by multimodal spatial omics modeling with MISO

Resolving tissue complexity by multimodal spatial omics modeling with MISO

Author Correction: Resolving tissue complexity by multimodal spatial omics modeling with MISO

The virulence regulator VirB from Shigella flexneri uses a CTP-dependent switch mechanism to activate gene expression

Cell-type-directed design of synthetic enhancers

Genetics of circulating inflammatory proteins identifies drivers of immune-mediated disease risk and therapeutic targets

Pathogen evasion of social immunity

Staufen2-mediated RNA recognition and localization requires combinatorial action of multiple domains

MTH1 inhibition eradicates cancer by preventing sanitation of the dNTP pool

Lake Ohrid’s tephrochronological dataset reveals 1.36 Ma of Mediterranean explosive volcanic activity

Copenhagen Accord pledges are paltry

A neuroadaptive interface shows intentional control alters the experience of time

DNA aptamers against bacterial cells can be efficiently selected by a SELEX process using state-of-the art qPCR and ultra-deep sequencing

Combinatorial, additive and dose-dependent drug–microbiome associations

Amyloid-associated increases in soluble tau relate to tau aggregation rates and cognitive decline in early Alzheimer’s disease

Online monitoring of phytate content in plant residuals during wet-treatment

Mediterranean winter rainfall in phase with African monsoons during the past 1.36 million years

Spread of pathological tau proteins through communicating neurons in human Alzheimer’s disease

Serum neurofilament light protein predicts clinical outcome in traumatic brain injury

Global Spore Sampling Project: A global, standardized dataset of airborne fungal DNA

Fecal microbiome and metabolome of infants fed bovine MFGM supplemented formula or standard formula with breast-fed infants as reference: a randomized controlled trial

A locus on 19p13 modifies risk of breast cancer in BRCA1 mutation carriers and is associated with hormone receptor–negative breast cancer in the general population

Sulfated glycosaminoglycans inhibit transglutaminase 2 by stabilizing its closed conformation

The coordinated action of VCP/p97 and GCN2 regulates cancer cell metabolism and proteostasis during nutrient limitation

P53 represses pyrimidine catabolic gene dihydropyrimidine dehydrogenase (DPYD) expression in response to thymidylate synthase (TS) targeting

Author Correction: Spread of pathological tau proteins through communicating neurons in human Alzheimer’s disease

The prevalence and transcriptional activity of the mucosal microbiota of ulcerative colitis patients

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