Nature Search

Spatio-temporal analysis of prostate tumors in situ suggests pre-existence of treatment-resistant clones

Spatial heterogeneity in prostate cancer can contribute to its resistance to androgen deprivation therapy (ADT). Here, the authors analyse prostate cancer samples before and after ADT using Spatial Transcriptomics, and find heterogeneous pre-treatment tumour cell populations and stromal cells that are associated with resistance.

Maja Marklund
Niklas Schultz
Joakim Lundeberg
ResearchOpen Access17 Sept 2022
Nature Communications

Volume: 13, P: 1-18
Spatially resolved clonal copy number alterations in benign and malignant tissue

Copy number variations inferred from spatial transcriptomics data in benign and malignant tissue reveal clonal architecture at the organ-wide level.

Andrew Erickson
Mengxiao He
Joakim Lundeberg
ResearchOpen Access10 Aug 2022
Nature

Volume: 608, P: 360-367
Spatial maps of prostate cancer transcriptomes reveal an unexplored landscape of heterogeneity

Heterogeneity within tumors presents a challenge to cancer treatment. Here, the authors investigate transcriptional heterogeneity in prostate cancer, examining expression profiles of different tissue components and highlighting expression gradients in the tumor microenvironment.

Emelie Berglund
Jonas Maaskola
Joakim Lundeberg
ResearchOpen Access20 Jun 2018
Nature Communications

Volume: 9, P: 1-13
Loss of ZDHHC15 expression in a woman with a balanced translocation t(X;15)(q13.3;cen) and severe mental retardation

Mahmoud Reza Mansouri
Lena Marklund
Niklas Dahl
Research25 May 2005
European Journal of Human Genetics

Volume: 13, P: 970-977
Proteomic differences between focal and diffuse traumatic brain injury in human brain tissue

Sami Abu Hamdeh
Ganna Shevchenko
Niklas Marklund
ResearchOpen Access01 May 2018
Scientific Reports

Volume: 8, P: 1-15
Neurosurgical untethering with or without syrinx drainage results in high patient satisfaction and favorable clinical outcome in post-traumatic myelopathy patients

Ulrika Holmström
Parmenion P. Tsitsopoulos
Niklas Marklund
Research27 Mar 2018
Spinal Cord

Volume: 56, P: 873-882
Gait training after spinal cord injury: safety, feasibility and gait function following 8 weeks of training with the exoskeletons from Ekso Bionics

Carsten Bach Baunsgaard
Ulla Vig Nissen
Fin Biering-Sørensen
Research06 Nov 2017
Spinal Cord

Volume: 56, P: 106-116
Extracellular fluid, cerebrospinal fluid and plasma biomarkers of axonal and neuronal injury following intracerebral hemorrhage

Lovisa Tobieson
Henrik Zetterberg
Niklas Marklund
ResearchOpen Access20 Aug 2021
Scientific Reports

Volume: 11, P: 1-10
Dynamic protein changes in the perihaemorrhagic zone of Surgically Treated Intracerebral Haemorrhage Patients

Lovisa Tobieson
Bijar Ghafouri
Niklas Marklund
ResearchOpen Access28 Feb 2019
Scientific Reports

Volume: 9, P: 1-14

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Spatio-temporal analysis of prostate tumors in situ suggests pre-existence of treatment-resistant clones

Spatially resolved clonal copy number alterations in benign and malignant tissue

Spatial maps of prostate cancer transcriptomes reveal an unexplored landscape of heterogeneity

Loss of ZDHHC15 expression in a woman with a balanced translocation t(X;15)(q13.3;cen) and severe mental retardation

Proteomic differences between focal and diffuse traumatic brain injury in human brain tissue

Neurosurgical untethering with or without syrinx drainage results in high patient satisfaction and favorable clinical outcome in post-traumatic myelopathy patients

Gait training after spinal cord injury: safety, feasibility and gait function following 8 weeks of training with the exoskeletons from Ekso Bionics

Extracellular fluid, cerebrospinal fluid and plasma biomarkers of axonal and neuronal injury following intracerebral hemorrhage

Dynamic protein changes in the perihaemorrhagic zone of Surgically Treated Intracerebral Haemorrhage Patients

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