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Photocatalysis offers a promising pathway to upcycle plastic waste. Here the authors demonstrate how defective cadmium sulfide photocatalysts can convert real-world polylactic acid into the amino acid alanine under visible light.

The molecular mechanisms underlying the function of different cellular states in glioblastoma stem cells (GSCs) remain poorly understood. Here, the authors perform integrated single cell and bulk analysis of GSCs and identify potential therapeutic targets.

Stimuli responsive hydrogels can be used in optical communication, but are not always as complex as required. Here, the authors report the use of 4D hydrogel morphing for gated verification of optical information.

This study proposes an integrated sensing and communication (ISAC) scheme leveraging space-timecoding metasurfaces (STCMs), which enables concurrent wireless communication and sensing on a shared platform.

The photochemical properties of Electron Donor-Acceptor (EDA) complexes present exciting opportunities, but often require an inert atmosphere to maintain high efficiency. Here, the authors develop a photocatalytic system through rational design, which overcomes the oxygen-sensitive limitation of traditional EDA photocatalytic systems.

Dealing with radioactive pollution first requires the detection of radioactive species released to the environment. Here the authors show an ultrasensitive and selective way to detect ⁹⁰Sr, one of the most frequently discharged products from nuclear reactors.

The role of lactylation in non-histone proteins remains underexplored. Here, the authors investigate lactylation on ALDOA-K147 by proteomics, GCE, and biochemical assays, revealing its diverse regulatory effects on cellular processes, including metabolism, nuclear translocation and gene regulation.

DeepPrep is a preprocessing pipeline for functional and structural MRI data from humans. Deep learning-based modules and an efficient workflow allow DeepPrep to handle large datasets.

Wang et al. demonstrate that the vascular smooth muscle cell–dependent expression of TRPM7, an ion channel with kinase function, increases the levels of calcium and zinc and, thus, increases the MMP2 activity and contributes to the formation of abdominal aortic aneurysm.

It may be possible to find non-Abelian electronic states in the higher bands of flat-band materials. Now a detailed transport study of the second moiré band of twisted bilayer MoTe₂ maps out several topological and magnetic states.

Auxin can promote or inhibit hypocotyl elongation. This biphasic effect has puzzled generations of plant biologists. Wang et al. shows that the decreasing apoplastic pH, stimulated by auxin, underlies the change in hypocotyl growth response.

Chen et al. present a deep learning-based lead optimization model that combines generative artificial intelligence with structure-based approaches. The method is successfully applied to the design of drug-like molecules targeting the recently identified LTK protein target with high potency and selectivity.

An X-ray signal that oscillated with a period of 85 s is inferred to arise from a rare intermediate-mass black hole tearing apart a nearby star. The signal provides constraints on the mass and spin of this black hole.

The detection of X-ray or gamma-ray spectral lines in gamma-ray bursts (GRBs) is rare. Here, the authors report a probable evidence of a narrow emission feature at about 2.1 mega-electron volts (MeV) in the spectrum of GRB 221023A, which represents the second event following GRB 221009A with a narrow emission feature in the MeV energy range.

Reverse osmosis of seawater is a popular though energy demanding process to produce freshwater. Interfacing reverse osmosis membranes with solar steam generation shows potential for a more efficient desalination process.

Synthesizing functionalized polyethylenes via ethylene coordination copolymerization using vinyl polar monomers is challenging. Here, the authors present an approach utilizing binuclear Ni catalysis for ethylene/acrylamide copolymerization to synthesize cyano-functionalized polyethylenes.

This study uses machine learning to design a coolhouse film that regulates temperature and water evaporation to maximize plant photosynthesis efficiency. The film selectively transmits the sunlight needed for photosynthesis, improving crop yield and survival rates in hot, arid regions.

The combination of targeted therapeutic agents for metastatic colorectal cancer (mCRC) salvage treatment has potential in clinics. Here this group conducts a single-arm, open-label, phase II trial assessing the combination therapy of regorafenib (tyrosine kinase inhibitor) and sintilimab (PD-1 targeting) as a safe and effective salvage-line treatment for mCRC patients who have progressed upon second-line treatment.

The authors report the transformation of an amorphous covalent organic framework to a crystalline state. This results in achieving optimum surface properties and enhances the photocatalytic production of hydrogen gas.

Here the authors characterise the cellular and molecular progression of lung alveolar damage in severe COVID-19 patients using integrated histopathology and cell atlassing, pinpointing a role for macrophage SPP1 signalling to vasculature in this process.

This study develops a climate-energy model for cascading power outages during climate extremes, validated by Hurricane Fiona’s blackout. It reveals unique resilience patterns and quantifies the effects of renewable integration and energy storage.

Here, the authors identify integrin beta 4 (ITGB4) as a key entry factor for Zika virus infection. An antibody targeting ITGB4 protects against viral infection and prevents fetal damage in mice, offering a potential therapeutic strategy.

Despite the lower device efficiency, tin perovskite based solar cells are preferred choices compared to lead-based counterparts due to much lower toxicity. Here Jiang et al. use a fullerene derivative to greatly suppress carrier interface recombination and obtain record high cell efficiency of 12%.

Ferroelectric field-effect transistors based on molybdenum disulfide can be used to build an in-memory sparsity architecture in which index memory is moved next to individual synapses, creating a sparse neural network without external memory indexing.

In this study, multiple μ-spatially offset Raman spectroscopy is used to determine blood glucose levels noninvasively in humans, achieving comparatively high accuracy in a clinical setting.

The hydroallylation of alkenes represents a straightforward method for the construction of chain elongated alkenes. Here the authors report a scandium-catalyzed anti-Markovnikov hydroallylation reaction of styrene derivatives with 1-aryl-2-alkyl alkenes and α-alkenes for the synthesis of chain elongated internal alkenes.

Amines are typically synthesized by aminating organooxygenates with ammonia and noble metal catalysts. Here, the authors reveal the potential of using affordable 3d-transition metal nitrides with nitrogen gas (N₂) as the nitrogen source to produce organonitrogen compounds, offering a new pathway for amine synthesis.

Here, Ma et al. investigate the translational profile of cardiac regeneration, pointing to Nat10 as a key regulator of cardiomyocyte proliferative potential, and describing how it regulates cardiac gene expression.

Inch-sized bulk lanthanide oxychloride single crystals and single-crystalline thin films with thickness down to the monolayer are synthesized through flux-enabled oriented attachment, providing a library of van der Waals materials with interesting dielectric and quantum properties.

Structural and cellular assays and molecular dynamics simulations reveal the mechanism of action of γ-glutamyl carboxylase, which involves cholesterol and vitamin K.

Artificial regulation of translation by intracellular RNAs has many potential applications. Here, authors design a platform capable of miRNA-triggered upregulation or downregulation using a single RNA construct, and demonstrate its use in constructing logic gates and cell-type classifiers.

Designing efficient circularly polarized light sources requires a balance between the photoluminescence quantum yield and the luminescence dissymmetry factor. Here, the authors develop indium-based chiral metal halides with efficient CPL characteristics by modulating their structural dimensions.

A recent synthesis study found 54% of the high-latitude peatlands have been drying and 32% have been wetting over the past centuries, illustrating their complex ecohydrological dynamics and highly uncertain responses to a warming climate.

Quantum simulation has the potential to enable experimentally studying problems which are not directly tractable in a laboratory or computationally. Here, the authors simulate the Majorana equation with a ytterbium ion, which requires them to simulate antiunitary and therefore unphysical operations.

Unlike neonatal mammalian hearts, adult hearts have limited regenerative capacity. Here, the authors explore the use of extracellular vesicles collected from neonatal hearts flowing damage, explore the difference in protein expression and delivery potential to trigger myocardial repair.

The development of carbonylative reactions with CO gas under mild conditions are important in organic synthesis. Here, the authors demonstrate an earth-abundant nickel-catalyzed three-component tandem acylzincation/cyclization sequence of allene and alkylzinc reagent with 1 atm of CO.’

Compatibility issues often limit chemoenzymatic systems. Now it is shown that the proximity between catalytic polymers grafted from the membrane of microorganisms and intracellular heterologous enzymes enhances the reaction rates of a photoenzymatic system, while the coating increases the stability.