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This study shows that protein kinase A (PKA) drives bone lesions in fibrous dysplasia and that targeting it in mouse models reduces disease severity, highlighting PKA as a promising therapeutic target for fibrous dysplasia.

Probing endogenous protein localization and function in vivo remains challenging due to laborious gene targeting and monofunctional alleles. Here, using a toolkit consisting of genetically-encoded epitope probes, their cognate tags, and an array of adapter proteins, the authors describe a methodology that enables visualization and manipulation of endogenous proteins in vertebrate systems.

Europium halide perovskitoids are new class of lead-free emitters with high efficiency due to symmetry allowed 5d−4f transitions. Here the authors design europium bromides with narrow emission through suppressing electron-phonon coupling.

Optically generated microwaves offer exceptionally low noise, crucial for radar and communications. Here, authors demonstrate a compact photonic chip-based interleaver multiplying pulse rates of mode-locked lasers to 14 GHz, significantly enhancing microwave power and reducing phase noise.

Recently, the quantum anomalous Hall effect has been successfully achieved in the intrinsic magnetic topological insulator MnBi₂Te₄, but zero-field quantization has proved difficult to achieve due to poor sample quality. Here, the authors report zero-field quantization and chiral edge states in five-septuple-layer MnBi₂Te₄.

The electrocatalytic upgrading of CO₂/CO provides a promising route to produce carbon-neutral alcohols but suffers from product loss to crossover and dilution. Here, the authors report on a CO reduction electrolyzer that recovers over 85% of alcohol without dilution, which is then scaled to 800 cm².

Two genetically linked TdNLR genes from wild emmer wheat are both required for YrTD121-mediated stripe rust resistance. The TdNLR1 and TdNLR2 pair lacks an integrated ___domain, representing an uncommon architecture for paired NLRs in plants.

The mainstream passivation strategies routinely rely on crystalline materials for perovskite photovoltaics. Here, authors utilize a solid phase reaction to prepare an amorphous (lysine)₂PbI₂ layer to neutralize surface and interface defects, achieving device efficiency of over 26% for solar cells.

A turn-key-operable hybrid integrated Pockels laser based on an external distributed Bragg waveguide grating reflector fabricated in a wafer-scale thin-film lithium niobate on insulator platform is demonstrated, with a tuning efficiency of over 550 MHz V^–1, tuning rates reaching the exahertz per second, and a high output power of 15 mW.

While Bell inequalities have been violated several times—mostly in photonic systems—their violations within particle physics experiments are less explored. Here, the BESIII Collaboration showcases Bell-violating nonlocal correlations between entangled hyperon pairs.

Ionogels have been integrated into soft robotics, though it is challenging to design gels with learning and memory capabilities. Here the authors introduce ionic-double-layer ionogel using cation-π interactions to program the ionogel.

Unlike that in plants, fungi, and marine animals, bacteria are vastly underrepresented in the production of terpenoids. Here, the authors report a systematic screening of terpene synthases from bacteria and identify three new skeletons that are not found in other organisms.

While the STING-type-I interferon pathway plays a key role in anti-tumour immunity, current direct STING agonists have limited therapeutic benefit. Here, the authors identify ENPP1 as a safer and more effective STING-modulating target than direct STING agonism, and use an AI-based drug design platform to design the ENPP1-selective inhibitor ISM5939.

Real-time road damage detection is crucial for public transportation management. Here, authors present a lightweight neural network framework that enables efficient surface distress recognition on mobile devices for transportation engineering.

An acid-free atmospheric leaching process extracts 97.4% Ni and 98.8% Co from critical minerals, limits iron dissolution (4.7%), and reduces CO₂ emissions by 59.5%, offering a sustainable alternative for battery-grade metal production.

Data from two large longitudinal cohorts in China, in which the participants were clustered into five groups based on their metabolic characteristics, show that a signature of microbiome age modulates the risk of cardiovascular disease in metabolically unhealthy individuals.

A complete genome assembly of a crab-eating macaque, revealing 46% fewer segmental duplications and 3.83 times longer centromeres than those of humans, is presented, enhancing understanding of lineage-specific phenotypes, adaptation and primate evolution.

Mid-Pleistocene climatic and ecological transitions and the formation of modern desert and loess landscapes and river networks emerge as critical events during the dispersal of early hominins in Palearctic Eurasia.

CO₂ electroreduction to higher-value carbons can occur through adsorbed hydrogen or through proton-coupled electron transfer from water. Understanding the impact of each route on product selectivity is challenging. Now H/D isotopic labelling reveals the contribution of each mechanism towards product formation and shows that adsorbed hydrogen dominates the reaction.

Catalytic syngas conversion is an essential part of sustainable chemical production but is hindered by the trade-off between conversion activity and product selectivity. Here the authors address this challenge by developing a catalytic shunt strategy.

The performance of n-i-p perovskite-organic tandem solar cells is hampered by non-ideal interconnection layers. This study reports an optimized metal-based interconnection stack featuring high transparency and efficient carrier recombination, achieving 25.34% efficiency and improved stability in tandems.

Wastewater treatment plants are important reservoirs of antibiotic resistance genes (ARGs). Here, the authors analyze ARGs in a global collection of samples from wastewater treatment plants across six continents, providing insights into biotic and abiotic mechanisms that appear to control ARG diversity and distribution.

Polynary perovskite oxides are promising air electrodes for rSOCs, with configuration entropy (S_config) often linked to reactivity. However, high S_config alone does not strongly correlate with performance. This study develops a model identifying key descriptors to guide high-activity oxide discovery.

The authors reported an interfacial composite design that accommodates high oxide fraction and large stretchability, providing implications for developing stretchable composites with enhanced optical, electrical, thermal, and magnetic properties.

The instability of quantum dot inks hinders the scaling up of colloidal quantum dot electronics. Now, Shi and team stabilize the inks with an iodine-rich environment in a weakly coordinating solvent, achieving 13.4% in small-area solar cells and over 10% in modules.

The dual-atom electrocatalyst shows great promise, but designing an active and stable catalytic center remains challenging. Here the authors design sulfur, nitrogen co-doped carbon nanosheets with asymmetrically coordinated double atomic iron centres for active and stable water oxidation in anion exchange membrane electrolyser.

Supported single atoms are promising catalysts for alkane dehydrogenation, although tuning their reactivity via active site modulation remains a challenge. Here the authors introduce an Ir₁–Cu₁ dual-atom catalyst for n-butane dehydrogenation that outperforms the corresponding Ir₁ single-atom system.

Asparagales is the largest monocot order. Here, the authors produce the phylogeny of Asparagales with transcriptomic data from 455 species and investigate the evolution of genes involved with allium flavor biosynthesis.

Impaired mitochondrial long-chain fatty acid β-oxidation (mtLCFAO) in type 2 alveolar epithelial (AT2) cells is thought to aggravate alveolar inflammation in acute lung injury. Here, the authors show that the mtLCFAO rate limiting enzyme CPT1a is decreased in AT2 cells in acute respiratory distress syndrome, highlighting the role of mtLCFAO in immunometabolism in this context.

The molecular mechanisms underlying the late-onset adverse effects of radiotherapy remain to be explored. Here, the authors observe compromised wound healing capacity in irradiated skin from breast cancer survivors and highlight THBS1 as a key epigenetically primed wound repair-related gene.

Unlike neonatal mammalian hearts, adult hearts have limited regenerative capacity. Here, the authors explore the use of extracellular vesicles collected from neonatal hearts flowing damage, explore the difference in protein expression and delivery potential to trigger myocardial repair.

Eukaryotic ribosome assembly involves multiple AAA+ ATPase hexamer mediated maturation steps. Here, authors report the structural analysis of the human SPATA5/SPATA5L1/CINP/C1ORF109 ATPase complex, revealing its role in cytoplasmic pre-60S maturation.

Accessing analogs capable of mimicking ortho- and meta-substituted anilines remains challenging due to the lack of a versatile and modular synthetic method. Here, the authors present a modular approach to access a diverse array of saturated bioisosteres of anilines via photoelectrochemical-induced decarboxylative C(sp³)–N Coupling.

Dual-atom catalysts with precise active sites are gaining attention, but further studies are needed to optimise their construction and understand their catalytic synergy. Here the authors report a series of asymmetric selenium-based dual- atom catalysts that comprise heteronuclear SeN2–MN2 (M = Fe, Mn, Co, Ni, Cu, Mo, etc.) active sites for the efficient oxygen reduction reaction.

This study elucidates that d-galacturonic acid and d-glucuronic acid regulate apple fruit softening by repressing MdHb1 expression through the MdMYB2/MdNAC14/MdNTL9-MdHb1 regulatory module, offering new insights into postharvest fruit quality control.

Electrochemical CO2 reduction is a promising method of producing sustainable chemicals and fuels, yet is highly energy intensive. Here, the authors couple CO2 electrolysis with hydrogen oxidation using a Ni(OH)₂/NiOOH auxiliary electrode to enhance energy efficiency.

Two competing models—disassembly/reassembly and displacive—have been proposed for how immature spherical HIV virions transform into mature particles with conical cores. Here the authors provide evidence that both disassembly/reassembly and displacive processes occur sequentially during the maturation process.

Previous work has argued for a CO₂ control on the development of the Plio-Pleistocene Transition (PPT, 3.0–2.5 Ma) Greenland Ice Sheet (GrIS). Here based on transient ice sheet experiments, the authors demonstrate the pivotal role of modern-like CO₂ on the onset and dynamism of the PPT GrIS.

Current view of the impact of A-site cation on the stability of perovskite materials and devices is derived from accelerated ageing tests at high temperature, which is beyond normal operation range. Here, the authors reveal the great impact of ageing condition on assessing the photothermal stability of mixed-cation perovskites using high-throughput robot system coupled with machine learning.