Antimicrobial proteins have been implicated in inflammatory bowel disease (IBD). Here the authors report, using both mouse genetic models and human samples, RNASE4 as a potential antimicrobial protein targeting Parasutterella to alter gut microbiota and metabolite homeostasis, impact susceptibility to IBD, and serve as a potential target for IBD therapy.
- Jun Sun
- Muxiong Chen
- Jinghao Sheng
