Nature Search

Genome-wide analyses identify 30 loci associated with obsessive–compulsive disorder

Genome-wide analyses identify 30 independent loci associated with obsessive–compulsive disorder, highlighting genetic overlap with other psychiatric disorders and implicating putative effector genes and cell types contributing to its etiology.

Nora I. Strom
Zachary F. Gerring
Manuel Mattheisen
ResearchOpen Access13 May 2025
Nature Genetics

Volume: 57, P: 1389-1401
Author Correction: Next-generation phenotyping integrated in a national framework for patients with ultrarare disorders improves genetic diagnostics and yields new molecular findings

Axel Schmidt
Magdalena Danyel
Matias Wagner
Amendments and CorrectionsOpen Access24 Jun 2025
Nature Genetics

P: 1-2
External validation of artificial intelligence for detection of heart failure with preserved ejection fraction

Whether deep learning of echocardiograms can improve recognition of heart failure with preserved ejection fraction (HFpEF) compared to clinical scores remains uncertain. Here the authors show that such a model would improve identification of HFpEF and patients at risk of adverse outcomes.

Ashley P. Akerman
Nora Al-Roub
Jordan B. Strom
ResearchOpen Access25 Mar 2025
Nature Communications

Volume: 16, P: 1-12
Next-generation phenotyping integrated in a national framework for patients with ultrarare disorders improves genetic diagnostics and yields new molecular findings

Exome sequencing within a structured diagnostic process for rare diseases in Germany shows how facial image analysis and machine learning can guide variant prioritization and uncover many ultrarare diseases.

Axel Schmidt
Magdalena Danyel
Matias Wagner
ResearchOpen Access22 Jul 2024
Nature Genetics

Volume: 56, P: 1644-1653
Trans-ancestry genome-wide association meta-analysis of prostate cancer identifies new susceptibility loci and informs genetic risk prediction

A meta-analysis of genome-wide association studies across different populations highlights new risk loci and provides a genetic risk score that can stratify prostate cancer risk across ancestries.

David V. Conti
Burcu F. Darst
Christopher A. Haiman
Research04 Jan 2021
Nature Genetics

Volume: 53, P: 65-75
Germline variation at 8q24 and prostate cancer risk in men of European ancestry

Chromosome 8q24 is known to be a major susceptibility region for prostate cancer risk. Here the authors analyze genetic data across the 8q24 region from 71,535 prostate cancer patients identifying 12 risk loci, three previously unreported, highlighting the contribution of germline variation at this locus.

Marco Matejcic
Edward J. Saunders
Christopher A. Haiman
ResearchOpen Access05 Nov 2018
Nature Communications

Volume: 9, P: 1-11
Identification of shared and differentiating genetic architecture for autism spectrum disorder, attention-deficit hyperactivity disorder and case subgroups

Cross-disorder genetic association analyses identify five loci differentiating attention-deficit hyperactivity disorder (ADHD) and autism spectrum disorder (ASD). Individuals diagnosed with both ADHD and ASD are double-loaded with genetic risk for both disorders.

Manuel Mattheisen
Jakob Grove
Anders D. Børglum
Research26 Sept 2022
Nature Genetics

Volume: 54, P: 1470-1478
Genetic architecture of 11 major psychiatric disorders at biobehavioral, functional genomic and molecular genetic levels of analysis

Joint analysis of 11 major psychiatric disorders identifies four broad factor underlying genetic correlations among the disorders. Association analyses detect 152 loci acting on these factors and identify 9 loci that act heterogeneously across disorders.

Andrew D. Grotzinger
Travis T. Mallard
Michel G. Nivard
Research05 May 2022
Nature Genetics

Volume: 54, P: 548-559
Atlas of prostate cancer heritability in European and African-American men pinpoints tissue-specific regulation

Over one hundred loci have been identified to be associated with the familial risk of prostate cancer but the functional effects are poorly understood. Here the authors use single-nucleotide variant and epigentic data to show an underlying genetic architecture marked by histone modification.

Alexander Gusev
Huwenbo Shi
Bogdan Pasaniuc
ResearchOpen Access07 Apr 2016
Nature Communications

Volume: 7, P: 1-13
Characterizing prostate cancer risk through multi-ancestry genome-wide discovery of 187 novel risk variants

A multi-ancestry genome-wide association study of prostate cancer performed in 156,319 cases and 788,443 controls identifies 187 novel risk variants associated with the disease. Genetic risk scores associated with overall risk, and risk of aggressive disease in men of African ancestry.

Anqi Wang
Jiayi Shen
Christopher A. Haiman
Research09 Nov 2023
Nature Genetics

Volume: 55, P: 2065-2074
Genome-Wide Association Study of Obsessive-Compulsive Symptoms including 33,943 individuals from the general population

Nora I. Strom
Christie L. Burton
Paul D. Arnold
ResearchOpen Access28 Mar 2024
Molecular Psychiatry

Volume: 29, P: 2714-2723
Leveraging population admixture to characterize the heritability of complex traits

Noah Zaitlen, Alkes Price and colleagues report a new approach to estimate the narrow-sense heritability of complex traits from unrelated individuals in a recently admixed population. They apply this approach to estimate the heritability for 13 quantitative or case-control phenotypes in 21,497 African-American individuals and suggest the inflation of family-based h² estimates.

Noah Zaitlen
Bogdan Pasaniuc
Alkes L Price
Research10 Nov 2014
Nature Genetics

Volume: 46, P: 1356-1362
A meta-analysis of 87,040 individuals identifies 23 new susceptibility loci for prostate cancer

Rosalind Eeles, Christopher Haiman and colleagues report genome-wide association and meta-analyses of prostate cancer in populations of European, African, Japanese and Latino ancestry. They identify 23 new susceptibility loci, including one associated with early-onset prostate cancer.

Ali Amin Al Olama
Zsofia Kote-Jarai
Christopher A Haiman
Research14 Sept 2014
Nature Genetics

Volume: 46, P: 1103-1109
Meta-analysis of genome-wide association studies of hoarding symptoms in 27,651 individuals

Nora I. Strom
Dirk J. A. Smit
Danielle Cath
ResearchOpen Access15 Nov 2022
Translational Psychiatry

Volume: 12, P: 1-8
A burden of rare copy number variants in obsessive-compulsive disorder

Matthew W. Halvorsen
Elles de Schipper
James J. Crowley
ResearchOpen Access27 Oct 2024
Molecular Psychiatry

Volume: 30, P: 1510-1517
Ecosystem response persists after a prolonged marine heatwave

Robert M. Suryan
Mayumi L. Arimitsu
Stephani G. Zador
ResearchOpen Access18 Mar 2021
Scientific Reports

Volume: 11, P: 1-17
Author Correction: Germline variation at 8q24 and prostate cancer risk in men of European ancestry

Marco Matejcic
Edward J. Saunders
Christopher A. Haiman
Amendments and CorrectionsOpen Access17 Jan 2019
Nature Communications

Volume: 10, P: 1-5
Publisher Correction: Trans-ancestry genome-wide association meta-analysis of prostate cancer identifies new susceptibility loci and informs genetic risk prediction

David V. Conti
Burcu F. Darst
Christopher A. Haiman
Amendments and Corrections20 Jan 2021
Nature Genetics

Volume: 53, P: 413
Correction: Meta-analysis of genome-wide association studies of hoarding symptoms in 27,537 individuals

Nora I. Strom
Dirk J. A. Smit
Danielle Cath
Amendments and CorrectionsOpen Access22 Dec 2022
Translational Psychiatry

Volume: 12, P: 1
Polygenic risk score-based phenome-wide association study identifies novel associations for Tourette syndrome

Pritesh Jain
Tyne Miller-Fleming
Peristera Paschou
ResearchOpen Access23 Feb 2023
Translational Psychiatry

Volume: 13, P: 1-10
A dimensional perspective on the genetics of obsessive-compulsive disorder

Nora I. Strom
Takahiro Soda
Lea K. Davis
ReviewsOpen Access21 Jul 2021
Translational Psychiatry

Volume: 11, P: 1-11

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